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SYNERGY-VAE: An explainable generative deep learning framework for discovering depression subgroups from multimodal population health data

Depression represents a complex, multifactorial disorder influenced by the interplay of biological, behavioral, and social determinants. While extensive health surveys, including the National Health and Nutrition Examination Survey (NHANES), gather comprehensive multidomain data, existing studies tend to analyze these domains independently, overlooking the potential to identify integrated, data-driven patterns of depression risk. We have developed SYNERGY-VAE, an interpretable and multimodal...

Sep 24, 2026Read Abstract →

Evolution of scaffold materials for periodontal therapeutics over two decades (2005-2025): A bibliometric mapping analysis

This study employed bibliometric methods to summarize the global distribution patterns, knowledge systems, and dynamic changes in hotspots of research on periodontal treatment scaffold materials over a 20-year period (2005-2025). Relevant literature related to periodontal diseases and scaffold materials was from the Web of Science Core Collection. A total of 528 eligible English-language articles were identified and analyzed using CiteSpace and VOSviewer software for visualizing and interpreting...

Sep 21, 2026Read Abstract →

Direct microhaplotype genotyping for GT-seq (Genotyping-in-Thousands by Sequencing) using a diploid abundance model

GT-seq (Genotyping-in-Thousands by Sequencing) is widely used for high-throughput amplicon genotyping, but most analytical pipelines focus on single SNPs or rely on alignment-based variant calling. Here we present a direct microhaplotype genotyping framework that leverages the high read depth and low error rates typical of paired-end Illumina and Element sequencing. The pipeline first identifies primer-bounded reads and resolves paired-end sequences into quality-aware consensus amplicon...

Sep 18, 2026Read Abstract →

Bibliometric Analysis of Gut Microbiota and Hepatocellular Carcinoma: Research Trends and Frontiers

CONCLUSION: The field shows rapid expansion with a China-USA dual research high-output research pattern, shifting toward microbial metabolites and microbiota-targeted immunotherapy. This work provides comprehensive quantitative data to compensate for missing panoramic and staged analyses in prior literature; future advances rely on causal mechanism verification, large-scale clinical trials and strengthened international collaboration.

Sep 18, 2026Read Abstract →

Global trends and emerging frontiers in cancer immunotherapy and gut microbiota-derived metabolites: a bibliometric analysis

CONCLUSIONS: Microbial metabolites have emerged as key functional mediators shaping responses to cancer immunotherapy, reflecting a shift from microbiome composition toward metabolite-centered mechanisms. This field is undergoing a transition from descriptive profiling to mechanism-oriented and translational research. These findings provide important insights for developing microbiota-targeted strategies to enhance the efficacy of cancer immunotherapy.

Sep 18, 2026Read Abstract →

Research Trends in Publications on Yoga and Meditation Interventions for Nurses' Mental Well-Being and Work Productivity: A Bibliometric Analysis

ObjectiveTo map publication trends and the thematic, geographical, and collaborative structure of research on yoga, meditation, and related contemplative practices among nurses.MethodsA bibliometric analysis was conducted using the Scopus database. The search combined terms relating to mental well-being, stress, burnout, quality of life, productivity, yoga, meditation, mindfulness, mind-body interventions, and nursing personnel, with publication years restricted to 2015-2024 and English-language...

Sep 18, 2026Read Abstract →

Utilization of a HIPAA-compliant large language model chatbot in an academic pediatric medical center

Despite growing interest in LLM chatbots, little evidence exists on usage patterns in hospital systems. This paper presents a mixed-methods case study of "InternalGPT," a HIPAA-compliant LLM chatbot made available to employees of the institution. Survey responses and 14 months of system utilization data were analyzed across diverse professional roles in the institution. Of approximately 15,800 hospital employees, 2,149 (13.6%) requested InternalGPT access. Motivations for sign-up aligned with...

Sep 17, 2026Read Abstract →

Systematic review of biosecurity interventions for the prevention of porcine reproductive and respiratory syndrome virus

BACKGROUND: A systematic scientific literature review was conducted to identify proven interventions for reducing the risk of porcine reproductive and respiratory syndrome virus (PRRSV) outbreaks on farms to inform decision-making by producers and veterinarians.

Sep 16, 2026Read Abstract →

Twelve-month real-world outcomes of sparsentan in a multicenter Spanish IgA nephropathy cohort

CONCLUSIONS: In this multicenter real-world Spanish cohort, sparsentan was associated with a sustained reduction in proteinuria in patients with biopsy-proven IgAN, maintained up to 12 months, along with preserved kidney function even in those with moderately reduced baseline eGFR, and a favorable safety profile. These findings support the effectiveness of sparsentan on top of contemporary standard of care and provide early evidence of sustained benefit in routine clinical practice.

Sep 16, 2026Read Abstract →

Structural biases in digital health intervention and health equity research: a bibliometric knowledge graph analysis (2015-2025)

CONCLUSION: This field faces "knowledge disorder under exponential growth." There are systematic biases in geography, theme, and power structure. We recommend building a core literature database, creating interdisciplinary journals, supporting reverse innovation led by low- and middle-income countries, and reforming academic evaluation systems to bridge the gap between research and policy translation.

Sep 16, 2026Read Abstract →

Explore barriers and risks that hinder AI integration into global talent management: A Systematic Review

The work environment is rapidly changing due to the constantly rising global disruptions. It has therefore become essential for organisations to retain their top talent in order to remain sustainable. This systematic review aimed to identify the primary barriers and risks associated with implementing Artificial Intelligence (AI) in Global Talent Management (GTM). A systematic literature review was undertaken in accordance with PRISMA-ScR standards. The review searched eight databases (Google...

Sep 11, 2026Read Abstract →

Gender difference in the authorship of top anesthesiology and pain journals: a protocol for retrospective bibliometric study

INTRODUCTION: The number of women in medicine has increased, and female scientists play an important role in medical research. However, bias in research publication and funding persists, which may influence the representation of women in medical studies. This study aims to explore women's representation in the authorship of top-five high-impact anesthesiology and pain journals over the past ten years, particularly during the COVID-19 pandemic period.

Sep 10, 2026Read Abstract →

Equity in Orthopaedic Knowledge, Open-Access Trends Among the Top 1,000 Cited Articles in Orthopaedic Surgery

CONCLUSION: Despite positive trends in open access, most influential knowledge in orthopaedic surgery remains closed access, representing a notable barrier to the global orthopaedic community.

Sep 9, 2026Read Abstract →

Endoscopic spine surgery: a bibliometric and citation analysis of the most influential articles and authors across 19 spine journals (1976-2025)

CONCLUSION: This bibliometric analysis highlighted the rapid advancement of the field of endoscopic spine surgery and highly cited authors who have been prominent within this field. This work particularly underscores a growing international focus on minimally invasive spinal techniques and the need for continued high-quality comparative studies.

Sep 9, 2026Read Abstract →

Global, regional, and national prevalence of second-hand smoke and attributable disease burden in 204 countries and territories, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023

BACKGROUND: Second-hand smoke (SHS) exposure remains a major source of morbidity and mortality among non-smokers. This study presents the first dedicated Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) publication to systematically quantify SHS prevalence and evaluate its effect as a global risk factor across a broader range of outcomes.

Sep 7, 2026Read Abstract →