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CONCLUSION: S-UAS probably improve stone clearance and reduce fever and may reduce sepsis; the evidence on severe complications is very uncertain. The effect on septic shock and a possible advantage of the flexible tip need randomized confirmation.
Generalized joint hypermobility, GJH is common. Hypermobility can have various negative consequences and comorbidities, especially when criterion for Hypermobility Spectrum Disorder, HSD and Ehlers-Danlos syndrome, EDS are met.The prevalence of these different conditions is lacking. Therefore, the aim of this study was to assess the prevalence of these hypermobility disorders. A systematic search was conducted January 25, 2024 and updated May 28, 2025. It included the databases Ovid MEDLINE,...
Studies using routinely collected healthcare data are essential for understanding the benefit-risk profile of medications in pregnancy. However, reproducibility is limited by the lack of shared pregnancy identification algorithms, and generalizability is constrained by their development primarily in commercial insurance databases. A previously developed pregnancy identification algorithm was updated for ICD-10-CM and translated into a standardized format to support transport across diverse...
BACKGROUND AND OBJECTIVES: Cognitive frailty (CF), the co-occurrence of physical frailty and cognitive impairment without dementia, is a potentially reversible condition associated with adverse outcomes in older adults. However, heterogeneity in operational definitions and measurement approaches limits comparability and clinical translation. This review examined how CF has been defined and operationalized, including adaptations to established criteria.
To address the pediatric obesity pandemic disproportionately affecting Latino children, particularly in the Caribbean, this study developed and validated a culturally tailored Spanish version of the Family Nutrition Physical Activity (FNPA) instrument for the Dominican context. Through a multi-step iterative process involving bilingual medical professionals, ten healthcare providers, and 50 guardians of children aged 6-12, the tool underwent rigorous translation and cognitive validation....
CONCLUSION: CS provides a dynamic framework for prognostication in gallbladder cancer and may support risk-stratified follow-up.
Heart failure represents the terminal stage of various cardiac diseases; the global prevalence of heart failure has been steadily increasing and poses a significant public health burden. With ongoing advances in molecular biology, clinical epidemiology, and translational medicine, research on heart failure has progressed significantly. Thus, understanding of the pathogenesis of heart failure has expanded beyond traditional hemodynamic abnormalities to encompass multidimensional, interrelated...
INTRODUCTION: In 2021, the European Society of Cardiology updated its guidelines for managing heart failure with reduced left ventricular ejection fraction (HFrEF), recommending a four-drug regimen combining a sodium-glucose cotransporter 2 (SGLT2) inhibitor, a beta-blocker, a mineralocorticoid receptor antagonist, and a renin-angiotensin-aldosterone system inhibitor. This study assessed, 6 months after guideline publication, the exposure of this quadruple therapy in patients newly hospitalized...
CONCLUSIONS: The global prostate cancer burden is shifting towards transitioning countries, where low MIRs reveal major gaps in early detection. Prioritising risk-stratified screening and strengthening health-system infrastructure in resource-limited settings are urgently needed to guide global policy.
CONCLUSIONS: Genitourinary cancers exhibit geographic and socioeconomic inequalities, with pronounced heterogeneity in potentially attributable burden across modifiable risk factors and HDI levels. These findings support context-specific prevention and health-system strategies.
CONCLUSIONS: The PUFA index is a recognized oral health index that has shown steady adoption across numerous studies and diverse populations. Its global credibility has positioned it for integration into modern surveillance frameworks, including the updated WHO STEPS Oral Health Module. Future priorities include standardizing reporting, strengthening integration into surveillance systems, and exploring how the PUFA index can be used in program evaluation to better inform policy and reduce oral...
CONCLUSIONS: Tegoprazan-containing first-line therapy may provide a small improvement in H. pylori eradication compared with PPI-containing therapy, particularly in 14-day quadruple regimens. Current evidence does not establish a clinically meaningful advantage in safety or adherence, and the findings should be interpreted in light of clinical heterogeneity, geographic limitations, and limited evidence in refractory or special populations. Further well-designed randomized trials are needed.
Since 2000, the UCSC Genome Browser (https://genome.ucsc.edu) has served as a standard tool for visualizing and comparing annotations across thousands of genome assemblies. Users can browse and visualize a wide range of data types from gene annotations to regulatory regions and comparative genome alignments. Once the data view is configured, the Genome Browser image can be exported for use in publications. Beyond visualization, users can use our tools to compare and export the annotations for...
CONCLUSIONS: Perceptions among stakeholders centred on prioritising future FOPL evaluation and education and on ensuring adequate resources are allocated to ensure that FOPL is properly implemented within supportive environments.
CONCLUSIONS: Substantial global disparities exist in breast cancer burden and outcomes. While high-income countries experience higher incidence, low-resource settings bear disproportionately higher mortality. Strengthening early detection, treatment access, and cancer control systems is essential to reduce global inequities and address the growing burden of breast cancer.