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Implementation of an artificial intelligence-based system for mammography in the compulsory medical insurance program: results of a 3-year study

CONCLUSIONS: Iterative testing with prospective real-world monitoring, interleaved developer updates, and radiologist feedback substantially enhanced mammography AI performance. This lifecycle testing methodology demonstrates feasibility for clinical integration and CMI program deployment, balancing rigorous validation with continuous improvement. Future work will focus on expanding the retrospective calibration testing dataset and scaling the approach to a national level within the CMI...

Sep 6, 2026Read Abstract →

Patient, Family, and Caregiver Engagement in the Development of Palliative Care Quality Indicators: A Scoping Review

ObjectiveQuality indicators (QIs) are vital to appraising and improving palliative care and should reflect the needs of patients, family members, and caregivers. This scoping review describes how patients', family members' and/or caregivers' priorities, preferences, and needs are incorporated into the development of palliative care QIs.MethodsWe conducted a scoping review in accordance with the framework developed by Arksey and O'Malley and updated by Levac et al We searched MEDLINE, EMBASE,...

Sep 6, 2026Read Abstract →

Commercial Automated Insulin Delivery Systems in Type 1 Diabetes Pregnancy: Protocol for a Mixed-Methods Systematic Review and Meta-Analysis of Glycaemic, Perinatal, Psychosocial and Implementation Outcomes

BACKGROUND: Commercial automated insulin delivery (AID) systems are increasingly used in pregnancies complicated by Type 1 diabetes, but the evidence is dispersed across trials, observational studies, case series and qualitative research. Existing syntheses have largely emphasised glycaemic efficacy and selected perinatal outcomes, with less attention to device platform, timing of initiation, psychosocial burden, clinician workload and implementation context.

Sep 5, 2026Read Abstract →

The landscape of adult obesity in Malaysia: a mapping of evidence and contemporary narrative review

Malaysia has one of the highest adult overweight/obesity rates (54.4%) regionally, with prevalence projected to keep rising. We mapped and synthesized updated Malaysian adult overweight/obesity research to guide practice and policy. We searched Web of Science, PubMed, and Google Scholar (English, 2016-2024) for studies on adult overweight/obesity in Malaysia. We organized eligible studies into the scopes defined by the national Nutrition Research Priority and conducted thematic narrative...

Sep 5, 2026Read Abstract →

Rapid review of gender-affirming healthcare for children and adolescents: Evidence synthesis (2021-2025) and recommendations for South Africa

CONCLUSION: Evidence supports the safety and effectiveness of GAHC for TGD youth. Strengthening affirming care, timely clinical access, and protective policies in South Africa may improve healthcare engagement and support the delivery of integrated adolescent, sexual health, and HIV-related services for TGD youth.

Sep 5, 2026Read Abstract →

Maternal respiratory syncytial virus vaccination for infant protection: updated systematic review and meta-analysis of efficacy, effectiveness, and safety

BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of severe illness in infants and young children.

Sep 5, 2026Read Abstract →

Infection-triggered encephalopathy syndromes: a meta-analysis of clinical characteristics and outcomes in 1946 cases

BACKGROUND: Infection-triggered encephalopathy syndromes (ITES) are acute, para-infectious disorders that can cause disability or death. Recognition is increasingly important in viral pandemics, but clinical features and outcomes remain poorly understood.

Sep 5, 2026Read Abstract →

The first key for the Priority Pathogens: Protective immunogens in development of vaccines and medications

The World Health Organization has updated the Priority Pathogens List based on risk assessments of the world's endemic pathogens, the majority of which are viruses. This assessment proposed to extend research and preparation to the entire families of Priority Pathogens, rather than just focusing on individual known high-risk pathogens. The 21 viruses on the Priority Pathogens List belong to 13 virus families. Viruses within the same family have similarities in genes, immunogens, immunity, and...

Sep 5, 2026Read Abstract →

Netupitant versus aprepitant: model-predicted neurokinin-1 receptor occupancy and implications for long-delayed nausea and vomiting prevention

CONCLUSIONS: Single-dose netupitant maintained NK(1) RO substantially longer than repeated- and single-dose aprepitant, suggesting greater potential for prolonged prevention of nausea and vomiting in ADC-treated patients. Prospective clinical validation of these model predictions would be beneficial.

Sep 5, 2026Read Abstract →

Military Sexual Trauma and Eating Disorders: A Systematic Review and Meta-Analysis

Military sexual trauma (MST) poses a significant public health concern within military populations, with enduring health consequences including the development of eating disorders (EDs). This review synthesizes existing literature to explore the association between MST and EDs among U.S. military populations. A systematic search of electronic databases including PubMed, Embase, and PsycINFO was conducted. Inclusion criteria included observational studies published in peer-reviewed journals,...

Sep 5, 2026Read Abstract →

Knowledge and Compliance of the Health Workers on the International Code of Breastmilk Substitute (BMS Code) in Nigeria

CONCLUSIONS: Health workers' knowledge of and compliance with regulations and low. Attention should be given to ensuring proper dissemination, sensitization, training, and facility-level procedures to improve regulation adherence and protect breastfeeding.

Sep 5, 2026Read Abstract →

Prevalence and Associated Factors of Depressive Symptoms Among Persons Aged 45 Years and Older in Indonesia in 2023: Overall and Sex-Specific Analyses

CONCLUSION: Depressive symptoms affected about one in ten persons 45 years and older in Indonesia in 2023 and were associated with poorer physical health, including hospitalisation, disability, multisite pain, poor self-rated health, and overweight. Among men, current smoking was an additional risk factor.

Sep 5, 2026Read Abstract →

Treatment updates in myotonic disorders

Myotonia is delayed muscle relaxation after forceful contraction. It is due to hyperexcitability of the skeletal muscle membrane. It can arise from primary skeletal muscle ion channel dysfunction, involving chloride or sodium channels, but is also a prominent clinical feature in myotonic dystrophies where altered RNA splicing leads to secondary ion channel dysregulation amongst other systemic manifestations. Clinically, myotonia can range from delayed eye opening to a disabling symptom causing...

Sep 5, 2026Read Abstract →

A five-phase evaluation framework for diagnostic and predictive medical artificial intelligence

Artificial intelligence (AI) has advanced rapidly across diagnostic, prognostic, and clinical decision-support applications, yet the pathway from laboratory performance to demonstrable clinical benefit remains fragmented and inconsistently defined. Existing evaluations rely heavily on retrospective testing and algorithm-centric metrics, while current guidelines emphasize reporting standards rather than specifying validation across stages of model maturity. This study proposes a five-phase...

Sep 5, 2026Read Abstract →

A formative evaluation of the implementation of a medication management transition of care stewardship service for patients discharged from rural and remote hospitals: A qualitative study of clinicians and patients

CONCLUSION: Overall, a medication-centred discharge service in the form of a virtual TOCS pharmacist and their facilitation of post-discharge HMRs were found to be an acceptable intervention to enhance continuity of medication management for patients discharged from hospital to home in rural and remote areas.

Sep 4, 2026Read Abstract →