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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

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Seasonal and Age-Stratified Patterns of Influenza, COVID-19, and RSV in Poland (2024-2026)

Respiratory syncytial virus (RSV), influenza viruses, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain major causes of seasonal respiratory morbidity, yet their contemporary temporal relationships and age-specific dynamics are insufficiently characterized. We analyzed nationwide Polish surveillance data for the 2024/25 and 2025/26 epidemic seasons, reporting the weekly infection burden per 100,000 population, both overall and by age group (0-4, 5-19, 20-59, and ≥60 years)....

Sep 26, 2026Read Abstract →

Duration of the Humoral Immune Response to Influenza Vaccination in a Cohort of Repeatedly Vaccinated Adults over Four Consecutive Epidemic Seasons: 2018/19-2021/22 Observational Study

Background/Objectives: The impact of repeated annual influenza vaccination on long-term immunogenicity and protection remains debated. Although reduced fold-increases in antibody titers are often observed in repeatedly vaccinated individuals, the effect on the duration of the humoral response remains poorly understood. This study evaluated the magnitude and persistence of the humoral immune response over four consecutive seasons. Methods: An open-label observational study was conducted between...

Sep 26, 2026Read Abstract →

Maternal Immunization Against Respiratory Syncytial Virus: An Updated WAidid Consensus Document on Evidence, Implementation, and Public Health Priorities

CONCLUSIONS: Maternal vaccination and infant monoclonal antibodies should be positioned within a coordinated prevention pathway. Maternal vaccination may serve as the principal strategy for appropriately timed pregnancies with reliable antenatal access, while infant monoclonal antibodies are particularly important when maternal vaccination is absent, too close to delivery, or potentially ineffective, or when the infant is preterm or otherwise at increased risk. Surveillance and locally adapted...

Sep 26, 2026Read Abstract →

Molecular Detection of Enteric Protozoa in Cattle from North Portugal

A total of 100 fecal samples collected from cattle in the district of Viana do Castelo, northern Portugal, were molecularly screened for Cryptosporidium spp., Giardia duodenalis, and Blastocystis sp. This study represents the first molecular survey of enteric protozoa in cattle from the district of Viana do Castelo, northern Portugal. Blastocystis sp. was the most frequently detected protozoan and exhibited considerable subtype diversity, including the zoonotic subtype ST3 and the potentially...

Sep 26, 2026Read Abstract →

Potentially Inappropriate Medication Use in Older Adults in Primary Care According to Four Explicit Criteria: Associations with Patient Factors

Background and Objectives: Potentially inappropriate medication (PIM) use is associated with adverse clinical outcomes in older adults. Several explicit screening tools are available for identifying PIMs, but Romanian data regarding the application of updated criteria remain limited. This study aimed to assess PIM identification according to the STOPP v3, Beers, EU(7)-PIM criteria and PRISCUS v2, to compare PIM counts and PIM presence across criteria, and to explore associations between PIM...

Sep 26, 2026Read Abstract →

Association Between Vaginal Microbiota and Female Infertility: A Systematic Review and Meta-Analysis

Vaginal dysbiosis may contribute to female infertility, but evidence on specific microbiota patterns remains inconsistent. This meta-analysis updates the epidemiological evidence linking vaginal dysbiosis to reduced female fertility, with a particular focus on low-Lactobacillus vaginal microbiota (LL-VMB), bacterial vaginosis (BV), intermediate microbiota, and Community State Type (CST) subtypes. A systematic search was performed in PubMed, Embase, Web of Science, Scopus, and the Cochrane...

Sep 26, 2026Read Abstract →

Highlighting Ophthalmic Adverse Effects Associated with Isotretinoin

Isotretinoin is a highly effective treatment for moderate-to-severe acne vulgaris but is associated with a broad spectrum of ophthalmic adverse effects. While dry eye disease secondary to meibomian gland dysfunction is the most common ocular complication, less familiar manifestations include nyctalopia, corneal abnormalities, retinal changes, idiopathic intracranial hypertension, and optic neuritis. Current evidence suggests that isotretinoin induces structural and functional changes in the...

Sep 26, 2026Read Abstract →

Adjunctive Synbiotic Therapy for Helicobacter pylori Eradication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

CONCLUSIONS: Adjunctive synbiotics may modestly improve H. pylori eradication and may reduce overall adverse events. However, the eradication benefit was not confirmed in PP analyses, and the safety findings should be interpreted cautiously given the limited pediatric evidence.

Sep 26, 2026Read Abstract →

Primary Cutaneous Lymphomas and Lymphoproliferative Disorders: Current Insights for Classification and Management

CONCLUSIONS: Integrating the updated diagnostic classifications with modern risk-stratified and targeted treatment paradigms is crucial for optimizing clinical management and avoiding overtreatment in indolent PCLs while improving survival in aggressive subtypes.

Sep 26, 2026Read Abstract →

From Donor to Discovery and Diagnosis: A Comprehensive 2026 Review of International Biobanking Guidelines Underpinning Molecular Pathology-Driven Cancer Diagnostics, with a Practical Roadmap for Establishing a New Biobank

Molecular pathology-driven oncologic diagnostics-genomic profiling, transcriptomics, proteomics, and, increasingly, artificial intelligence applied to tissue and liquid biopsy-can only be as accurate as the biospecimens on which they are performed. Biobanks are the infrastructures that secure this foundation, linking donors, biological samples, and data to discovery and, through the pathology interface, back to diagnosis. Their scientific and diagnostic value, however, is determined less by the...

Sep 26, 2026Read Abstract →

Parenting and Child/Adolescent Development: Current Updates and Global Perspectives: Second Edition

The evidence consistently indicates that parenting and family environments are important determinants of child and adolescent health [...].

Sep 26, 2026Read Abstract →

Updated Age- and Sex-Specific Reference Values and Anthropometric Correlates of Maximum Handgrip Strength in Preschool Children from the Araucania Region, Chile

Background/Objectives: Handgrip strength is a simple and reliable indicator of muscular fitness during childhood. However, updated reference values for handgrip strength in preschool children remain limited in many countries, including Chile. This study aimed to develop updated age- and sex-specific reference values for maximum handgrip strength in preschool children aged 4-6 years from the Araucanía Region, Chile, and to examine its associations with age and anthropometric characteristics....

Sep 26, 2026Read Abstract →

Pediatric Mild Traumatic Brain Injury and Concussion: Modern Pathophysiological Insights, Diagnostic Advances, and Active Management Protocols

Traumatic brain injury and pediatric concussion represent major global public health concerns. This narrative review aims to provide an updated overview of pediatric concussion by integrating current evidence regarding pathophysiology, diagnostic advances, neuroimaging, biomarkers, and evidence-based management strategies. Concussion pathophysiology involves a complex neurometabolic cascade characterized by ionic imbalance, mitochondrial dysfunction, cerebral blood flow alterations, diffuse...

Sep 26, 2026Read Abstract →

Alcohol and Hypertension-A Fresh Look on the Mechanistic Aspects of a Fatal Epidemiologic Relationship

Arterial hypertension is a key trigger for all major, life-threatening cardiovascular events such as arrhythmia, stroke, cardiac infarction and heart failure. Ethanol consumption has been identified as a critical risk factor, which promotes hypertension and thereby corrupts cardiovascular health and limits overall life expectancy. For heavy drinkers (≥72 g/day), reduction in half of the alcohol consumption reportedly results in considerable decreases in systolic and diastolic blood pressure...

Sep 26, 2026Read Abstract →

Mutational Landscape of Primary Hyperoxaluria in Morocco: Update and Implications for Diagnosis

CONCLUSIONS: These results highlight the need for a simplified, exon-focused diagnostic strategy, particularly in resource-limited settings like Morocco.

Sep 26, 2026Read Abstract →