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CONCLUSIONS: COVID-19 continues to impose a substantial and persistent economic burden, even in the post-pandemic period, underscoring the importance of ongoing mitigation strategies and efficient healthcare resource planning.
Anaplastic lymphoma kinase (ALK) fusion gene is one of the most common driver genes in non-small cell lung cancer (NSCLC). ALK-tyrosine kinase inhibitors (TKIs) have become the standard treatment option for patients with advanced ALK gene fusion positive NSCLC. Currently, the China National Medical Products Administration (NMPA) has approved ten ALK-TKIs, including crizotinib, ceritinib, alectinib, ensartinib, brigatinib, lorlatinib, iruplinalkib, envonalkib, dirozalkib and conteltinib....
Recommendations and points to consider (PtCs) are important tools to improve the quality-of-care for people living with rheumatic and musculoskeletal diseases (RMDs). An important requirement of the European Alliance of Associations for Rheumatology (EULAR) recommendations and PtCs is that they resonate with clinical experience and are practical, easy to understand, and actionable. At the same time, they should commit to the 3 pillars of evidence-based medicine (best available research evidence,...
CONCLUSIONS: Residential greenness is unequally distributed across socioeconomic strata, with higher-income and better-educated urban residents consistently residing in greener neighborhoods. These findings provide evidence relevant to environmental injustice and support the development of equity-oriented urban greening policies that prioritize socioeconomically disadvantaged communities.
CONCLUSIONS: These findings provide updated, population-representative prevalence estimates of HOA outcomes in a contemporary and diverse cohort. HOA remains a substantial burden, particularly among individuals with obesity and prior hip injury, with presentation differing by sex. These results support targeted clinical screening in high-risk subgroups.
CONCLUSION AND NEXT STEPS: ECCO 2026 emphasized durable, precision-oriented, multidisciplinary, and technology-enabled IBD care across the full continuum, from prevention to long-term modification. Apart from phase 3 and extension trials, other results remain preliminary and need broader comparative and practice-embedded studies before widespread adoption.
BACKGROUND: General-purpose large language model (LLM)-based systems are increasingly accessible to clinicians and are being explored for applications in clinical microbiology and infectious diseases (ID). However, rapid adoption has outpaced the development of specialty-specific guidance, raising concerns related to safety, reliability, accountability, and antimicrobial stewardship.
CONCLUSION: After SVR, CME was associated with lower HCC risk; this possible duration-dependent inverse association was clinically interpretable only among metformin-eligible patients with T2DM.
To develop new reference weight charts to be used at post-mortem examinations of children aged 1-17 years old and to compare this data with that of the charts currently in use (collected from as far back as the 1930s). Weights were extracted from the reports of postmortems conducted at our institution between 2003 and 2024 and corresponding to cases in whom death presented suddenly and unexpectedly (both natural and unnatural). The data were grouped according to sex, age and height. The...
Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy in which transfusion support represents an essential component of comprehensive patient care. This review aims to provide an updated synthesis of recent progress in the development and clinical application of machine learning models based on multimodal big data for precision transfusion management in AML, addressing the persistent limitations of conventional, empirically guided transfusion practices. We...
Cognitive models of depression implicate impaired executive control, particularly in emotional contexts. However, few studies have directly compared "cold" (non-emotional) and "hot" (emotional) contexts, and the persistence of impairments following remission remains unclear. Diathesis-stress models propose that cognitive vulnerability is latent in remitted depression and emerges under negative mood or stress. This study compared hot and cold executive functioning among currently, remitted, and...
CONCLUSION: Aligning Thailand's framework with ASEAN and global trends, particularly digital health, interprofessional collaboration, and lifelong learning will strengthen future pharmacy education and practice.
Biomarkers are integral to modern breast cancer management by providing essential information for prognosis and treatment selection. This review presents the 2026 update of the recommendations of the Arbeitsgemeinschaft Gynäkologische Onkologie (German Gynecological Oncology Group, AGO) on therapy-relevant prognostic and predictive biomarkers. The recommendations are based on a structured evaluation of the most recent and clinically relevant evidence using the AGO grading system to support...
Spine-related leg pain (SRLP) is a common and clinically important presentation, affecting a substantial proportion of individuals with lumbar spine disorders. Compared to those with isolated axial low back pain, these patients experience higher pain intensity, greater disability, worse long-term outcomes, and increased healthcare utilization. Clinical management is complicated by inconsistent terminology among musculoskeletal healthcare providers, with the widespread and imprecise use of the...
CONCLUSIONS: FGIDs affect over half of Turkish infants and are associated with sleep disturbances and maternal depressive symptoms. Mixed breast-formula feeding independently increased FGID risk after age adjustment. Integrated care approaches addressing feeding practices, sleep quality, and maternal mental health are warranted.