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The Heavy Burden of Bullying on Student Wellbeing in NepalThe Emerging Landscape of Thyroid Health in Central NepalHow a Recent Western Nepal Study is Redefining Anemia DiagnosisHow H. Pylori is Impacting the Health of Karnali’s High-Altitude CommunitiesSweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s YouthHow Missing Checklists and Protocols are Costing Lives in Nepal’s ERsWhy Your Lungs May Hold the Secret to Your Stress LevelsWalking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali WorkersSilent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child AbuseThe Heavy Burden of Bullying on Student Wellbeing in NepalThe Emerging Landscape of Thyroid Health in Central NepalHow a Recent Western Nepal Study is Redefining Anemia DiagnosisHow H. Pylori is Impacting the Health of Karnali’s High-Altitude CommunitiesSweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s YouthHow Missing Checklists and Protocols are Costing Lives in Nepal’s ERsWhy Your Lungs May Hold the Secret to Your Stress LevelsWalking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali WorkersSilent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child Abuse

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Aesthetic Surgery Tourism: The Real Cost of Discount Plastic Surgery

CONCLUSION: Aesthetic surgery tourism is more affordable for patients short term, but the potential complications can jeopardize patient safety and place an increasing financial burden on our healthcare system. It is crucial to educate patients on the risks of traveling for aesthetic surgery. Potential interventions include education at pre-operative clearance appointments, providing options to consult a US board-certified plastic surgeon before traveling, and increasing domestic regulations.

Jun 15, 2026Read Abstract →

Emotion regulation variability and flexibility in daily life show distinct associations with well-being, age, and executive functions

Flexible and effective emotion regulation (ER) is crucial for mental health and well-being. Research on individual differences in ER, however, has often relied on global self-reports or controlled laboratory settings, which may not fully capture the dynamic and context-dependent nature of regulation in daily life. To address this, we examined how ER variability and flexibility in real-world contexts relate to executive functions (EF), affective well-being, and age in a general population sample...

Jun 15, 2026Read Abstract →

Aviation accident investigation analysis methodologies used by 12 government Safety Investigation Authorities

CONCLUSIONS: Multiple investigation analysis methodologies were used by all SIAs, sometimes in the same investigation. In contrast with aging ICAO publications and negative New View claims, the SIA research data illustrates choice and usage of complex systemic and less complex analysis methodologies in varying investigative contexts.

Jun 15, 2026Read Abstract →

Preparation methods, structural characterization, pharmacological properties, and potential industrial utilization of polysaccharides from Aloe vera: A review

Aloe vera polysaccharides (AVPs), particularly acemannan and related O-acetylated mannan/glucomannan fractions, are bioactive macromolecules that contribute substantially to the health-promoting properties of A. vera. In recent years, research on AVPs has advanced from conventional extraction and activity screening toward structure-preserving preparation, detailed structural characterization, mechanism-oriented pharmacological evaluation, and application-driven development. This review...

Jun 15, 2026Read Abstract →

Protocol for a CONSORT extension for reporting Pragmatic and Explanatory trials designed using the PRECIS tool. (CONSORT-PRECIS)

This research protocol outlines a systematic approach to updating the Consolidated Standards of Reporting Trials (CONSORT) extension for Pragmatic trials, originally published in 2008. Pragmatic trials, whose intention is to provide evidence for real-world decision makers choosing between alternative interventions, differ in design from explanatory trials, whose intention is to test hypotheses on mechanism of action often under tightly controlled conditions, which are often contrived in...

Jun 15, 2026Read Abstract →

NCCN Guidelines® Insights: Acute Myeloid Leukemia, Version 3.2026

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues. It is the most common form of acute leukemia among adults and accounts for the largest number of annual deaths from leukemias in the United States.1 The NCCN Guidelines Panel for AML convenes annually to update recommendations for the diagnosis and treatment of AML in adults. These recommendations are based on a...

Jun 15, 2026Read Abstract →

Buprenorphine for Cancer Pain: Evidence, Guidelines, and Clinical Rationale for Early Use

As cancer survivorship increases, long-term opioid therapy (LTOT) has become more common in oncology, raising concerns about opioid-related harms. Buprenorphine offers unique pharmacologic advantages that position it as a safer alternative to full agonist opioids (FAOs), yet it remains underutilized in the management of cancer pain (CP). This article reviews the clinical rationale, supporting evidence, and practical considerations for using buprenorphine in managing CP throughout the cancer care...

Jun 15, 2026Read Abstract →

WHO estimates of the global, regional, and national burden of 14 foodborne diarrhoeal enteric hazards, 2000-21: an updated data synthesis

BACKGROUND: Foodborne diseases cause significant illness and death globally. We updated WHO estimates of the burden caused by diarrhoeal hazards commonly transmitted by food: Campylobacter jejuni, Campylobacter coli, and other thermotolerant Campylobacter species; Cryptosporidium spp; Cyclospora cayetanensis; Entamoeba histolytica; enteroaggregative Escherichia coli; enteropathogenic E coli; enterotoxigenic E coli; Giardia duodenalis; norovirus; rotavirus; non-typhoidal Salmonella enterica;...

Jun 15, 2026Read Abstract →

WHO estimates of the global, regional, and national burden of eight foodborne non-diarrhoeal enteric disease hazards, 2000-21: an updated data synthesis

BACKGROUND: Foodborne diseases cause substantial illness and death globally. We updated WHO estimates of the burden caused by non-diarrhoeal enteric disease hazards: Brucella spp; Clostridium botulinum; hepatitis A virus; Listeria monocytogenes; Mycobacterium bovis,Mycobacteriumcaprae, and Mycobacteriumorygis; invasive non-typhoidal Salmonella enterica (iNTS); S enterica serotypes Paratyphi A, B, and C; and S enterica serotype Typhi (S Typhi).

Jun 15, 2026Read Abstract →

The epidemiology of violence against children in England, 1971-2024: A longitudinal ecological analysis of 1.7 million care entries

CONCLUSIONS: This study identifies a sustained reversal in long-term declines in children entering care in England since the mid-2000s. Considerable inequalities were observed across age, sex, and place. These findings underscore the need for long-term preventive policies addressing structural disadvantage alongside national responsive measures protecting children during periods of economic and societal disruption.

Jun 15, 2026Read Abstract →

Enhancing Patient-Centered Home Palliative Care for Heart Failure: A Concept Analysis to Guide Nursing Practice and Care Coordination

To identify and describe components of the home-based palliative care model for patients with heart failure, re-conceptualize the process, and update the existing model to inform nursing research and clinical practice. Heart failure, as a chronic progressive disease, has a continuously increasing incidence and medical burden, and requires multidimensional clinical management strategies. Although palliative care is recommended for improving the quality of life of heart failure patients, its...

Jun 15, 2026Read Abstract →

A nationwide survey on knowledge, attitude, and practice regarding human papillomavirus (HPV), HPV-related disease, and HPV vaccine among adolescents and their parents in China

Although human papillomavirus (HPV) infection constitutes a significant public health challenge, the HPV vaccination coverage remains suboptimal in China. Recent roll-out of new policies calls for an updated evaluation on the knowledge, attitude, and practice on HPV and HPV vaccination among adolescents and their parents. This nationwide cross-sectional survey targeted adolescents aged 9-17 y paired with one of their parents. Sociodemographic factors and the awareness, knowledge, attitude,...

Jun 15, 2026Read Abstract →

Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults

CONCLUSIONS AND RELEVANCE: In this test-negative case-control study, 2024-2025 COVID-19 vaccination was associated with reduced likelihood of medically attended COVID-19-associated outcomes among immunocompetent and immunocompromised adults, highlighting the importance of adults receiving recommended COVID-19 vaccinations.

Jun 15, 2026Read Abstract →

Correction: Manifesto of the collaborative alliance for research and educationin surgery: the CARES network. "Surgical research must become amilestone of progress in patient care in Italy"

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Jun 15, 2026Read Abstract →

From framework to practice: applying the proteus-practice framework to learn lessons for integrating PROs in clinical care

CONCLUSION: The PROTEUS-Practice Framework provided a structured approach for describing real-world approaches to PRO integration in clinical care. Its use enabled the identification of cross-cutting lessons learned that offer practical guidance for optimizing PRO integration and tailoring its use in diverse clinical contexts.

Jun 15, 2026Read Abstract →