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AI-Driven Mental Health Support for Caregivers of Individuals With Alzheimer Disease: Systematic Literature Review and Development of a Conceptual Framework

CONCLUSIONS: The proposed framework provides a chance for caregivers to receive mental health care, which will be personalized. The framework is developed with more updated methods than existing approaches, with a lack of personalization in this sector. This framework can be implemented with a goal of personalization and explainable approaches and can undergo further iterations to ensure it is appropriate for specific purposes.

Mar 6, 2026Read Abstract →

Integrated disease model considering mutation-induced infection waves with COVID-19 cases

COVID-19, an unprecedented global pandemic, has caused successive waves that pose unique challenges to public health and epidemiological research. Traditional Susceptible-Infected-Recovered (SIR) models often struggle to capture these complex dynamics, especially given that the virus has spawned multiple sub-variants. To tackle these challenges, we adopt an empirical modeling approach by integrating real-world data from Our World in Data (daily confirmed COVID-19 cases) and GISAID (variant...

Mar 6, 2026Read Abstract →

MYELOstudy: lymph node stage of aggressiveness in medullary thyroid cancer-a retrospective multi-center study analysis

Medullary thyroid carcinoma (MTC) is a rare, but biologically aggressive cancer that accounts for 1-2% of all thyroid malignancies. Its aggressiveness has been linked to distinct clinicopathological features. Novel pathological predictors of aggressiveness have also been described in the literature. However, these remain contentious, to date. To assess the prognosticators of aggressiveness for MTC and establish potentially novel ones. The primary endpoint was to establish predictors for central...

Mar 6, 2026Read Abstract →

The AuTOMATIC trial: a multicentre digitally-automated, Bayesian, adaptive, parallel, factorial randomised controlled trial of SMS reminders for childhood vaccination

BACKGROUND: The estimated effectiveness of SMS (short message service) reminders for improving childhood vaccine coverage and timeliness has varied in previous studies. The observed heterogeneity in effectiveness may be explained in part by variation in reminder content or timing of the reminder relative to the vaccine schedule date. We sought to evaluate the effectiveness of a range of SMS reminders of varied content and timing for improving on-time childhood vaccination.

Mar 6, 2026Read Abstract →

Smoking-attributable hospitalisation costs in Europe: an econometric analysis of the European Health Interview Survey, 2019

CONCLUSIONS: The results of this paper show that smoking imposes significant healthcare costs across the EU. Importantly, the total healthcare costs of smoking are likely to be significantly higher than reported in this study, which only focuses on two types of healthcare services. These updated estimates underscore the need to reinvigorate tobacco control policies at national and EU level to reduce the health and economic burden of smoking and protect the health systems resources.

Mar 6, 2026Read Abstract →

Cellular and molecular regulation of skin by ginseng and its bioactive Constituents: A review of studies from 2021 to 2025

The skin functions as the first line of defense against external and internal stressors, containing pathogen invasion, ultraviolet (UV) radiation, and the loss of collagen and hydrogen, all of which could finally cause skin damage and cellular senescence. Over time, a large plenty of strategies, including herb therapies, have been developed to protect skin health. Ginseng is a well-known traditional herbal medicine that has been widely applied in various diseases. In recent years, ginseng and...

Mar 6, 2026Read Abstract →

National Estimates of Nurse Practitioner Disaster Preparedness Training

We aimed to determine nationally representative differences in annual hazard-specific disaster preparedness training by health care provider shortage area (HPSA), practice rurality, patient population, and racial identity. Weighted estimates were generated from National Sample Survey of Registered Nurses (NSSRN) data. 15,408 surveys represented 208,866 nurse practitioners. Almost two-thirds had engaged in any disaster training annual updates. Fewer rural practitioners had trained for chemical...

Mar 6, 2026Read Abstract →

CartograPlant: Bridging genomic, phenotypic, and environmental data to advance plant resilience and eco-evolutionary insight

Climate change is threatening plant health and productivity at all spatial scales, and these impacts are further compounded by the rising incidence of invasive pests and pathogens. Effectively addressing these challenges requires a comprehensive understanding of plant demography as well as the mechanisms and drivers of adaptation. Achieving this understanding requires the integration of physiological, ecological, and genetic datasets. However, such integration is often hindered by disconnected...

Mar 6, 2026Read Abstract →

Beyond the capsule: an integrated perspective on the wide world of frozen shoulder. A collaborative viewpoint

CONCLUSION: Clinicians must move beyond solely addressing FS as a "local" pathology. Modern research indicates that FS is a complex pathology involving an inflammatory phase followed by a fibrotic shift, fueled by metabolic, inflammatory, neuroendocrine, and psychological factors.

Mar 6, 2026Read Abstract →

ADHD (over) diagnosis: fiction, fashion and failure

When thoroughly assessed, the prevalence of attention-deficit hyperactivity disorder (ADHD) in children/adolescents is estimated at 5%. There is no evidence that ADHD is over-diagnosed in the UK. Indeed, available data point to under-diagnosis, even though rigorous updated post-COVID-19 pandemic data are not available. Some cases may be misdiagnosed due to low-quality assessment, poor adherence to national guidance or inappropriate differential diagnosis. Beyond the controversy around over- or...

Mar 6, 2026Read Abstract →

Screener of Handwriting Proficiency: Student Performance and Expectations from Kindergarten Through Fifth Grade

Although handwriting skills are important for child development, there are limited screening tools available to measure print and cursive skills for performance or progress monitoring. The Screener of Handwriting Proficiency (SHP) is a quick non-standardized assessment designed to screen handwriting skills. A retrospective normative research design was used to begin establishing benchmarks using data of students who have completed the assessment compared to peers. The scores from kindergarten...

Mar 6, 2026Read Abstract →

Pharmacotherapy in the acute phase of secondary spinal cord injury: an updated narrative review

Following primary spinal cord injury (SCI), spinal neuronal tissues and their surrounding tissues undergo pathological degeneration, known as secondary SCI. Secondary SCI is a complex process involving progressive neurodegeneration caused by ischemia, inflammation, and oxidative stress. Current strategies for managing secondary SCI are debated, and evidence remains limited. This narrative review discusses the latest evidence on pharmacological approaches to the treatment of the acute phase of...

Mar 5, 2026Read Abstract →

Balance and physical activity in teenagers and young adults with cochlear implants: a Swedish cohort study

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Mar 5, 2026Read Abstract →

Human papillomavirus-encoded microRNAs: key regulators in cervical cancer development

Human papillomaviruses (HPVs) cause diverse cutaneous and mucosal diseases, with several genotypes strongly associated with cervical cancer. Beyond the well-established role of cellular microRNAs (miRNAs) in gene regulation, increasing evidence shows that HPV also encodes its own viral miRNAs (v-miRNAs). These v-miRNAs modulate both viral and host gene expression, influencing key pathways involved in oncogenesis, including cell cycle control, apoptosis, immune evasion, and epithelial -...

Mar 5, 2026Read Abstract →

A commentary on the updated research priorities in ophthalmology: implications and future directions

No abstract

Mar 5, 2026Read Abstract →