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Pharmacogenetics in HIV therapy: a review of key biomarkers, regulatory annotations, and clinical dosing guidelines

INTRODUCTION: Pharmacogenetics is pivotal in modern HIV management, facilitating the transition from the traditional "one-size-fits-all" model toward personalized precision medicine. By analyzing how unique genetic profiles influence pharmacological responses, clinicians can maximize therapeutic efficacy while minimizing toxicities and adverse drug reactions. Given the high interindividual variability in antiretroviral drug exposure and the necessity for lifelong treatment, identifying key...

Oct 16, 2026Read Abstract →

Protocol for a mixed methods realist evaluation of the Intervention to optiMise Palliative caRe for peOple with liVed Experience of homelessness (IMPROVE)

BACKGROUND: People experiencing homelessness have poor health outcomes as a result of co-occurring physical and mental health issues, frequently in association with addictions. They experience difficulties accessing all types of health care. As a result, they often die young, and with limited support.Based on previous research, a Community of Practice intervention was developed to facilitate local, inter-professional and inter-agency collaboration to improve health and social care for people...

Oct 16, 2026Read Abstract →

Triggers and Modifiers of Acute Coronary Events and Implications for Practice: An Umbrella Review

CONCLUSION: These findings highlight the role of triggers in acute coronary events. Future research should prioritise translating these insights into clinical nursing practice to mitigate acute event risk.

Oct 16, 2026Read Abstract →

Sensor-Informed Probabilistic Bridge Reliability Analysis: A Review

This review examines the integration of sensor data into probabilistic bridge reliability analysis, covering the workflow from sensor selection and data acquisition through preprocessing, computational Bayesian inference and reliability index β computation to remaining service life estimation and maintenance optimization. Sensor selection is treated as a reliability engineering decision, with sensing technologies matched to the target reliability variable and governing deterioration mechanism....

Oct 16, 2026Read Abstract →

Update in the Molecular Pathogenesis of Sebaceous Carcinoma

Sebaceous carcinoma is an uncommon but potentially aggressive adnexal malignancy whose molecular pathogenesis has been substantially clarified in recent years. Rather than representing a single molecular entity, sebaceous carcinoma is now understood as a biologically heterogeneous group of tumors arising through distinct yet sometimes overlapping oncogenic pathways. Recent genomic and multi-omics studies have identified several major molecular subsets, including mismatch repair-deficient...

Oct 16, 2026Read Abstract →

How Phylogenies Inferred from 46 Mitochondrial Genomes Informed the Systematics of the Australasian Genus of Ticks, <em>Bothriocroton</em>, with the Description of Three New Species

BACKGROUND: We revised the taxonomy and identification of the species of the genus Bothriocroton in light of entire mitochondrial genomes and nuclear rRNA genes, scanning electron microscopy, and light microscopy.

Oct 16, 2026Read Abstract →

Sex-Based Representation and Outcome Reporting in Thoracolumbar Burst Fracture Research: A PRISMA-ScR Scoping Review

Background/Objectives: Thoracolumbar burst fracture research has traditionally been male-skewed, but it remains unclear how often women are represented and whether outcomes are reported separately for women and men. This scoping review mapped sex-based representation and outcome reporting in clinical studies of adult traumatic thoracolumbar burst fractures. Methods: We conducted a prospectively planned scoping review in accordance with the PRISMA Extension for Scoping Reviews (PRISMA-ScR)....

Oct 16, 2026Read Abstract →

Adolescent Endometriosis: From Clinical Management to an Early Recognition and Prevention-Oriented Paradigm-A Narrative Review

CONCLUSIONS: Early recognition, timely referral, expert imaging when appropriate, individualized treatment, and follow-up centered on functional impact may reduce symptom burden in adolescents. Hormonal suppression is a clinically plausible strategy for symptom control and preservation of functioning, but it is not a proven disease-modifying or fertility-preserving intervention in adolescents.

Oct 16, 2026Read Abstract →

Recommendations for the Diagnosis and Treatment of Genitourinary Syndrome of Menopause from the Italian Society of Menopause (SIM) and Italian Society of Gynecology of the Third Age (SIGiTE)

Genitourinary syndrome of menopause (GSM) is a chronic condition associated with estrogen and androgen deficiency that affects the vulva, vagina, urethra, and bladder, significantly impairing quality of life, sexual wellbeing, and urinary function. Despite its high prevalence, GSM remains frequently underdiagnosed and undertreated. These recommendations, developed by the Italian Society of Menopause (SIM) and the Italian Society of Gynecology of the Third Age (SIGiTE), provide updated...

Oct 16, 2026Read Abstract →

Institutional Variation in MRI Utilization After Prostatectomy for Prostate Cancer: A Multicenter Study

Background/Objectives: Healthcare utilization may vary because of institutional practice patterns and policy context. This study aimed to evaluate institutional variation and clinical factors associated with repeated MRI examinations after prostatectomy and to explore whether cumulative MRI use was associated with overall survival. Methods: This retrospective multicenter study included 3754 patients who underwent prostatectomy for prostate cancer at seven hospitals. Repeated MRI examinations...

Oct 16, 2026Read Abstract →

Update of Korean Medicine Clinical Practice Guidelines for Obesity Management: An Evidence-Based GRADE Approach

CONCLUSIONS: The update of the KMCPGs underscores the clinical value of KM interventions in obesity management while emphasizing the need for further high-quality studies to strengthen the evidence. Addressing implementation barriers and ensuring regular guideline updates are essential for optimizing clinical application and improving patient outcomes in obesity care.

Oct 16, 2026Read Abstract →

Advancing Research Governance in Nepal: Lessons from the NHRC-ICMR Technical Exposure Visit

The Nepal Health Research Council (NHRC) and the Indian Council of Medical Research (ICMR) established a bilateral collaboration under a Memorandum of Understanding (MoU) signed (January 2021) to foster scientific exchange, capacity building, and health research ethics. NHRC officials comprising research officers, ethics administrators and journal office staff completed an exposure visits to the ICMR headquarters in New Delhi in February 2026. The visit's sessions were centered on ethical...

Oct 16, 2026Read Abstract →

Research gap and its impact on women's health

Currently, we are in a global context where women's human rights, particularly equality and autonomy, have gained increasing relevance. At the same time, national and international documents have been updated, and knowledge about violence against women has expanded, recognizing its various forms (physical, psychological, and sexual) as well as its different settings (family, community, workplace, and healthcare). This highlights that many aspects of women's health are deeply linked to inequality...

Oct 15, 2026Read Abstract →

Optimal Incidence Threshold for Cost-Effective Hepatocellular Carcinoma Surveillance in Alcohol-Associated Cirrhosis

CONCLUSION: Routine biannual HCC surveillance with ultrasound and AFP is cost-effective for patients with alcohol-associated cirrhosis in the United States when HCC incidence exceeds 0.45 per 100 person-years, substantially below the historically cited 1 per 100 person-years threshold. Updating clinical guidelines to reflect these contemporary thresholds could improve early HCC detection in this high-risk population.

Oct 15, 2026Read Abstract →

Eleven-year surveillance of Pseudomonas aeruginosa infections and antimicrobial resistance trends in a Portuguese tertiary hospital, 2014 - 2024: Trends and insights into novel agents

CONCLUSIONS: These findings reveal a shifting resistance landscape and underscore the need for sustained surveillance, antimicrobial stewardship, and updated empirical treatment strategies, while highlighting a critical gap in contemporary epidemiological data.

Oct 15, 2026Read Abstract →