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•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels

clinical trials

Live updates directly from PubMed Research

Tooth brushing versus routine oral care impact on ventilator-associated pneumonia in PICU: a clinical trial

CONCLUSION: Although adding toothbrushing to routine chlorhexidine oral care did not produce a statistically significant reduction in VAP incidence or mortality, a consistent trend toward clinical benefit was observed across multiple outcome measures, including lower rates of positive sputum cultures, reduced inotropic support requirements, and fewer new pulmonary infiltrates. These findings highlight the potential value of enhanced oral hygiene in the PICU and support the need for larger...

Jul 25, 2026Read Abstract →

Development of a core descriptor set for studies assessing interventions for diabetes-related foot ulceration

CONCLUSIONS/INTERPRETATION: This CDS reflects characteristics important to health professionals and researchers when reporting clinical studies on diabetes-related foot ulceration. Its use will aid the reporting of future studies.

Jul 25, 2026Read Abstract →

ASO Visual Abstract: Improved Oncologic Outcomes with Trimodality Therapy for Radiation-Associated Angiosarcoma of the Breast

No abstract

Jul 25, 2026Read Abstract →

Romiplostim for chemotherapy induced thrombocytopenia in pediatric cancers

CONCLUSIONS: Prophylactic romiplostim didn't hasten platelet recovery in pediatric patients receiving myelosuppressive chemotherapy but was associated with reduced bleeding and had lower transfusion requirements. There was a significant relative immature platelet fraction percentage (IPF)% increment on day 16 in the romiplostim arm in comparison to the control arm, reinforcing the biological plausibility of romiplostim's effect on megakaryocyte stimulation.

Jul 25, 2026Read Abstract →

Dual therapy vs bismuth quadruple therapy in recurrent H. pylori: multicenter randomized trial

CONCLUSIONS: Bismuth-based dual therapy is a superior alternative to classical bismuth quadruple therapy for the treatment of patients with at least one failed therapy for H. pylori, as it provides greater eradication with superior safety and compliance.

Jul 25, 2026Read Abstract →

Proximity to an SGC-DLPFC Individualized Functional Target and Electric-Field Modeling Do Not Predict Clinical Outcomes of rTMS for Treatment-Resistant Depression

CONCLUSIONS: Under the specific fMRI acquisition parameters used, proximity to optimized DLPFC-SGC-iFTs was not associated with better outcomes in patients receiving neuronavigated rTMS to an optimized DLPFC-SGC group-target. Prospective randomized clinical trials definitively assessing the clinical utility of iFTs are warranted. .

Jul 25, 2026Read Abstract →

Food peptides and the immune system: A review of their effects on macrophages, lymphocytes, and cytokine production

Food-derived bioactive peptides (FDBPs) are short amino acid sequences encrypted within dietary proteins that can be released during digestion, food processing or fermentation and exert immunomodulatory effects. This review critically examines recent evidence on the interactions between FDBPs and the immune system, with particular emphasis on macrophages, lymphocytes, and cytokine production. Peptides derived from dairy, egg, marine, and plant proteins have been shown to influence key immune...

Jul 25, 2026Read Abstract →

Nutritional assessment and nutritional therapy for enterocutaneous and enteroatmospheric fistulas: a scoping review

Nutritional therapy can help balance effluent loss and fistula healing, and nutritional status is crucial for successful outcomes. The latest guidelines on the topic were published in 2016, and to answer the question "What are the nutritional strategies and tools used in the assessment and treatment of enterocutaneous and enteroatmospheric fistulas?", this scoping review included publications from 2016 onward, without age, sex, or language restrictions, identified through searches on PubMed,...

Jul 25, 2026Read Abstract →

Development and validation of a risk-stratification model for individualized management of leptomeningeal metastases in EGFR- mutant NSCLC (LM-Index)

CONCLUSION: We developed and validated a robust, clinically accessible risk score that accurately stratifies OS in patients with EGFR- mutant NSCLC and LM. This practical tool facilitates risk‑stratified patient counseling and may aid in the design of future clinical trials.

Jul 25, 2026Read Abstract →

Quality of life and productivity among esketamine responders in a real-world study in Australia and New Zealand

Treatment-resistant depression (TRD) is associated with severe depression, low quality of life (QoL) and reduced work productivity, which may increase risk of relapse, suicide and suboptimal response to treatment. Esketamine nasal spray plus a newly-initiated oral antidepressant (esketamine + OAD) has been shown to improve depression symptoms, QoL and productivity in patients with TRD; however real-world evidence is limited. This was a descriptive, exploratory post-hoc subgroup analysis of...

Jul 25, 2026Read Abstract →

primary analysis of the RANDOMIZED eortc-2139/columbus-ad trial: Adjuvant encorafenib and binimetinib versus placebo in high-risk stage II BRAF-V600E/K melanoma

CONCLUSION: EORTC 2139 - Columbus-AD demonstrated a consistent and manageable safety profile and encouraging efficacy results for the combination of enco and bini in resected stage IIB/C BRAF V600E/K-mutated cutaneous melanomas.

Jul 25, 2026Read Abstract →

Streamlining the Frequency, Conduct, and Location of Assessments in Registrational Lung Cancer Clinical Trials for Supplemental Applications: Recommendations of a LUNGevity Foundation Multistakeholder Working Group

The amount of data collected in oncology clinical trials has grown exponentially over recent years, posing significant burdens on trial participants, investigators, and trial sites. The frequency, magnitude, and strict standardization of trial-related assessments and data collection do not reflect routine clinical care and can limit participation of some patients and trial sites in clinical research. Though the use of simplified trial designs to align trial conduct more closely with routine care...

Jul 25, 2026Read Abstract →

An Observational Population Level Study of Neoadjuvant Chemoimmunotherapy for Resectable Non-Small-Cell Lung Cancer

CONCLUSION: In this real-world cohort, NCIT for resectable NSCLC achieved pCR and mPR rates comparable to pivotal clinical trials, with manageable toxicity and favorable surgical outcomes. These findings suggest no major efficacy-effectiveness gap, although longer follow-up is needed to assess survival outcomes.

Jul 25, 2026Read Abstract →

Therapeutic potential of antisense oligonucleotides in hematological malignancies

Antisense oligonucleotides (ASOs) are short synthetic oligonucleotides composed of DNA, RNA, or chemically modified nucleotides, that represent a promising class of therapeutics for personalized medicine. This review synthesizes the clinical evidence from published studies evaluating ASOs in myelodysplastic syndromes, acute myeloid leukemia, acute lymphoblastic leukemia and chronic lymphocytic leukemia. Preclinical investigations and early-phase clinical trials have yielded encouraging results,...

Jul 25, 2026Read Abstract →

Patient-reported outcomes from the TBCRC 022 study of neratinib and ado-trastuzumab emtansine for HER2-positive breast cancer brain metastases

CONCLUSION: This GI-focused PRO analysis highlights the value of PROs in capturing patient-experienced toxicities that impact quality of life yet are underestimated by clinicians. Incorporating PROs into clinical trials can inform supportive care and prophylactic strategies.

Jul 25, 2026Read Abstract →