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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

clinical trials

Live updates directly from PubMed Research

Bridging the Pregnancy Knowledge Gap: A Real-World Analysis of Medication Use and Drug-Drug Interaction Risk in Crohn's Disease and Multiple Sclerosis

The exclusion of pregnant individuals from clinical trials has resulted in a significant medical knowledge gap for this population. Leveraging real-world data (RWD) provides a critical window into the prevalence and use of medications during pregnancy. Using the health plan claims database IQVIA PharMetrics(R) Plus, we evaluated the use of disease-modifying therapies (DMTs) and concomitant medications in pregnant individuals. We focused on two case examples-Crohn's Disease (CD) and Multiple...

Aug 14, 2026Read Abstract →

PET/CT In paediatric lymphoma: Current role and advances

Fluorine-18 fluorodeoxyglucose ([^(18)F] FDG) PET/CT has become central to the management of paediatric lymphoma, providing critical information for staging, response assessment, and treatment adaptation. Its integration into international clinical trials and treatment protocols has enabled response-adapted strategies that improve outcomes while reducing long-term toxicity, particularly through the selective omission of radiotherapy in early responders. Beyond its established clinical role,...

Aug 14, 2026Read Abstract →

Evaluation of the mandibular third molar region using 2D vs 3D acquisitions with dental-dedicated MRI

CONCLUSIONS: Most anatomic features in the MTM region are adequately depicted with both 2D and 3D acquisitions. The 2D acquisition quality was sufficient for diagnostic purposes of the MTM region, while diagnostic capability of the 3D volumes remains uncertain.

Aug 14, 2026Read Abstract →

The future of blood-based biomarkers in liver cancer

Liquid biomarkers hold substantial promise in liver cancer, with potential applications in risk stratification, surveillance and early detection, therapeutic decision-making, and treatment-response monitoring. In parallel with oncologic advances, liquid biopsy has gained increasing attention. However, despite expanded research efforts, prospective clinical validation remains limited. While cell-free DNA-based detection of actionable alterations has entered clinical practice in select contexts,...

Aug 14, 2026Read Abstract →

Conduction disturbance recovery and permanent pacing requirement in bicuspid aortic valves post-TAVR

CONCLUSIONS: Nearly half of BAV patients with peri-procedural conduction injury recover without permanent pacing, supporting extended monitoring before committing to PPM implantation. Peripheral vascular disease and prior atrial fibrillation identify patients unlikely to recover and may guide earlier PPM placement. Sievers Type 1 L-R morphology and advanced age are associated with conduction risk and should inform pre-procedural planning.

Aug 14, 2026Read Abstract →

Nigella sativa (Black Seed) Oil Alleviates the Serum Levels of IL-6 and Insulin in Patients With Polycystic Ovary Syndrome

CONCLUSION: Twelve weeks of N. sativa oil supplementation were associated with significant improvements in inflammatory status and fasting blood glucose compared with placebo after baseline adjustment. However, no significant between-group effects were observed for insulin resistance indices or hormonal outcomes. These findings support the potential adjunctive role of N. sativa oil in PCOS while highlighting the need for larger adequately powered clinical trials.

Aug 14, 2026Read Abstract →

Comparative effectiveness of ofatumumab and ocrelizumab in relapsing multiple sclerosis: a target trial emulation using multinational registry data

CONCLUSIONS: Both therapies were highly effective in a large cohort of patients with RRMS, with very low relapse or CDP rates. Ofatumumab was associated with slightly greater disability control, while ocrelizumab more effectively suppressed relapses. These differences were modest, and their clinical relevance requires further evidence and should be interpreted with caution.

Aug 14, 2026Read Abstract →

A Randomized Basket Trial Design for Dose Optimization Based on Bayesian Model Averaging Using Spike-and-Slab Priors

The FDA initiated Project Optimus and issued guidance for dose optimization, recommending randomized parallel dose-response cohorts to generate additional data at promising dose levels and implying that different dosages may be needed for different indications. In addition to dose optimization, with recent advancements in precision medicine and cancer biology, the development of cancer treatments has shifted toward the search for agents targeted to specific molecular profiles that may appear in...

Aug 14, 2026Read Abstract →

DNA hypomethylation identifying clinical benefit subgroup of small-cell lung cancer: multi-omics analysis of a phase II trial with durvalumab plus olaparib as maintenance therapy

CONCLUSIONS: This study presents the first prospective evidence supporting durvalumab plus olaparib as maintenance therapy in ES-SCLC. Multi-omics analysis identifies that DNA hypomethylation status may enrich for patients who benefit from PARP inhibition and immunotherapy.

Aug 14, 2026Read Abstract →

Effect of scenario-based simulation on students' learning outcomes and satisfaction in perioperative anaphylaxis: a pilot randomised controlled trial

CONCLUSIONS: SBS demonstrates greater efficacy than VBT in improving anaesthesia students' learning outcomes, including technical and non-technical skills in managing perioperative anaphylaxis, with higher student satisfaction.

Aug 14, 2026Read Abstract →

Construction and clinical validation of a multidimensional stratified management path based on dynamic patient-reported outcomes (PROs) in cancer pain management: study protocol for a randomised controlled trial

BACKGROUND: Pain is one of the most prevalent symptoms among patients with cancer, and its presence and severity provide important prognostic information regarding survival. Patients with cancer pain experience a decline in their overall quality of life, along with a corresponding reduction in physical, cognitive, emotional and social functioning. Symptom management based on dynamic patient-reported outcomes (PROs) is recognised as the optimal 'patient - centered' healthcare model. However,...

Aug 14, 2026Read Abstract →

Hauora Manawa mō ngā Kaumātua me ngā Whānau: a co-designed community-based cohort study of cardiovascular health among older Māori in Canterbury, New Zealand-a study protocol

INTRODUCTION: Cardiovascular disease remains a leading cause of preventable mortality in Aotearoa New Zealand (NZ), with Māori continuing to experience earlier onset, higher hospitalisation rates and greater mortality than non-Māori. Despite this inequity, community-based data describing cardiac structure, function and circulating cardiovascular biomarkers in older Māori are very limited, particularly for those over 65 years. The Hauora Manawa mō ngā Kaumātua me ngā Whānau (Heart Health of Older...

Aug 14, 2026Read Abstract →

REenergizeME: intermittent hypoxia-hyperoxia treatment for myalgic encephalomyelitis/chronic fatigue syndrome-protocol for a randomised, placebo-controlled trial

INTRODUCTION: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, disabling condition characterised by post-exertional malaise (PEM), autonomic dysfunction and markedly reduced quality of life. Its prevalence has increased following the COVID-19 pandemic, yet no effective disease-modifying treatments are available and underlying mechanisms remain unclear. Evidence implicates immune-metabolic dysregulation, impaired energy metabolism, vascular dysfunction and altered oxygen...

Aug 14, 2026Read Abstract →

Combined activity-based therapy and transcutaneous spinal cord stimulation as an intensification and supplemental approach for upper limb sensorimotor recovery: a randomised controlled trial protocol for in-patients with subacute spinal cord injury

INTRODUCTION: Activity-based therapy (ABT) delivers intensive, repetitive sensorimotor stimulation to enhance neuroplasticity after spinal cord injury. ABT has demonstrated synergistic benefits with cervical transcutaneous spinal cord stimulation (tSCS) for motor recovery particularly in individuals with chronic cervical spinal cord injury. However, its efficacy in subacute cases remains an emerging area of research. Accordingly, this study aims to determine the efficacy of an adjunctive ABT...

Aug 14, 2026Read Abstract →

Effect of Herbal Mouthwash and 0.2% Chlorhexidine Mouthwash on Salivary Uric Acid and Oral Health-A Randomized Controlled Trial

CONCLUSION: The findings suggest a potential association between the use of herbal and Chlorhexidine mouthwashes and changes in salivary uric acid levels, which reflect improved oxidative balance in the oral cavity, along with improvements in clinical oral parameters. This supports further exploration of their clinical relevance in managing oxidative stress-related oral conditions.

Aug 14, 2026Read Abstract →