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•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"

clinical trials

Live updates directly from PubMed Research

Determinants of Infant and Young Child Feeding Practices of Children With Severe Acute Malnutrition in Agrarian and Pastoralist Settings of Ethiopia

Previous research has established determinants of young child feeding (IYCF) practices in the general child population, but determinants of these practices in children with severe acute malnutrition (SAM) are unknown. This study assessed the determinants of IYCF practices among children aged 6-23 months with SAM and under SAM treatment in a pastoralist and a predominantly agrarian setting in Ethiopia. As part of the baseline survey for the R-SWITCH cluster randomized control trial, we screened...

Jul 5, 2026Read Abstract →

Effectiveness of support-based interventions on self-efficacy in patients with diabetes: a systematic review and meta-analysis

This study conducted a systematic review and meta-analysis to examine the effect of social support interventions on improving self-efficacy in patients with diabetes. A literature search was performed using Medline, CINAHL, Cochrane Library, and Embase for studies published between January 2014 and December 2023. The risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool. Effect sizes and 95% confidence intervals were calculated using R software. This systematic review and...

Jul 5, 2026Read Abstract →

Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme

The Dame Barbara Windsor Dementia Goals Programme was launched by the UK Government to accelerate the development and delivery of new treatments for dementia. We present the recommendations from the Scientific Advisory Board, to enable timely access to therapies for the wider population, reducing health system burden while improving patient outcomes. The recommendations focus on three areas: (i) establishing a new dynamic national patient registry for clinical trial recruitment; (ii) the use of...

Jul 5, 2026Read Abstract →

Eco-friendly electrochemical innovative method depending on multiwalled carbon nanotubes/sugar polymer/zinc oxide nanoparticles carbon paste for the determination of urogenital drug mirabegron in dosage form and spiked human plasma

A sensitive, simple, and environmentally friendly electrochemical voltammetric approach has been developed for the determination of Mirabegron (MRG) in drug substances, drug products, and spiked human plasma samples. For the first time, MRG was measured using a combination of electrochemistry and nanotechnology. A Multiwalled carbon nanotubes/sugar polymer/ zinc oxide nanoparticles carbon paste electrode (MWCNT/ZnO NPs/PS/CPE) was fabricated and used to study the electrochemical behavior of MRG...

Jul 4, 2026Read Abstract →

Fracture resistance of maxillary lateral incisors: effects of fiber post dimensions, material, and surface treatment

CONCLUSIONS: Within the tested, anatomy-preserving ranges, longer and slightly 1.1 mm diameter posts, the tested quartz-fiber post system and abrasion-plus-silane conditioning can be combined to improve fracture resistance in restored maxillary lateral incisors, supporting strategies that maximise bonding while preserving dentine. Limitation/future work: As an in vitro static test with thermal ageing only, cyclic fatigue and long-term interface degradation remain uncertain and should be...

Jul 4, 2026Read Abstract →

Evaluation of orthodontic treatment need awareness in individuals with different malocclusions

CONCLUSION: Aesthetic perception is a key determinant of orthodontic treatment demand and is closely associated with malocclusion type. Therefore, patients' aesthetic concerns and awareness should be considered during orthodontic evaluation and treatment planning to optimize patient-centered outcomes.

Jul 4, 2026Read Abstract →

Effect of S-PRG containing coat on the shear bond strength and the prevention of enamel microcrack formation after orthodontic bracket removal: an invitro study

CONCLUSIONS: PRG BarrierCoat^(®) shows promise in enhancing shear bond strength with metal brackets. The high mineral content of PRG BarrierCoat^(®) enhances the integrity of enamel and helps in the prevention of microcrack formation. However, additional long-term clinical trials are required to confirm these findings under dynamic oral conditions.

Jul 4, 2026Read Abstract →

Integrating health economics and implementation science: a call to action

CONCLUSIONS: Greater collaboration between implementation scientists and health economists has the potential to optimise implementation strategies, provide robust evidence for value for money and ultimately improve care delivery. Stronger integration of health economics and implementation science may also shed more light on the equity impacts of implementation strategies and guide their further design to promote more equitable care and outcomes.

Jul 4, 2026Read Abstract →

Molecular mechanisms of coronary microembolization-induced MINOCA

Compared to classic myocardial infarction (cMI), myocardial infarction with non-obstructive coronary arteries (MINOCA) is characterized by symptoms consistent with acute coronary syndrome, but without demonstrable coronary obstruction. Therefore, its diagnosis remains challenging and often relies on cardiac magnetic resonance imaging (MRI), which is usually performed only days after the index event, leading to delayed diagnosis and initiation of therapy. Coronary microembolization (CME) has been...

Jul 4, 2026Read Abstract →

Plasma exosome-derived miRNA-887-5p alleviates high glucose- and lipid-induced endothelial cell dysfunction

CONCLUSION: Plasma exosomal miRNA expression is broadly reduced in people with T2DM complicated by AS. hsa-miR-887-5p, hsa-miR-96-5p, hsa-miR-183-5p, and hsa-miR-410-3p may emerge as candidates with diagnostic and therapeutic relevance in this context. Specifically, miR-887-5p mitigates high-glucose/high-lipid-induced vascular endothelial injury, warranting further investigation as a therapeutic target.

Jul 4, 2026Read Abstract →

Multidimensional Safety Assessment of a Low-Intensity Scanning Ultrasound (SUS) Protocol in Sheep

CONCLUSION: Collectively, the acute and long-term safety assessment of the brain after SUS advocates translation to human studies.

Jul 4, 2026Read Abstract →

Analytical outlier rates for Roche fifth generation cardiac troponin T stat using biotin sensitive and insensitive reagent lots

CONCLUSIONS: cTnT analytical outliers occurred more than twice as often using biotin-insensitive reagent on the Cobas e601 analyzer compared to biotin-sensitive reagent on the Cobas e411.

Jul 4, 2026Read Abstract →

GLP-1 Receptor Agonist Therapy in Children and Adolescents with Obesity: A Network Meta-Analysis of Differential Cardiometabolic Efficacy and Safety Profiles

CONCLUSION: In this network meta-analysis of adolescents with overweight or obesity, GLP-1RAs showed differential cardiometabolic profiles. Semaglutide 2.4mg produced the largest point estimates for weight-related outcomes, dulaglutide 1.5mg and lixisenatide 20 ug for glycaemic endpoints, and exenatide 20 ug for systolic blood pressure. These findings are hypothesis-generating: most active-treatment comparisons were indirect, many nodes were informed by single trials, and SUCRA rankings should...

Jul 4, 2026Read Abstract →

Real world evaluation of HIV-1 reservoir and resistance in virologically suppressed people after 52 weeks of treatment with long-acting cabotegravir + rilpivirine

CONCLUSIONS: In this real-world study, a stable HIV-1 DNA over 52 weeks of CAB+RPV LA treatment was observed. A substantial proportion of participants harboured NNRTI or INSTI major mutations, mostly APOBEC-context, without conferring true resistance. These findings emphasize the importance of a careful interpretation of proviral resistance.

Jul 4, 2026Read Abstract →

Conduction system pacing versus biventricular pacing for cardiac resynchronization therapy: frequentist and bayesian meta-analysis of randomized controlled trial and propensity matched studies

CONCLUSION: CSP may offer potential advantages over BiV pacing in patients indicated for CRT; however, confirmation in larger randomized clinical trials is required.

Jul 4, 2026Read Abstract →