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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

clinical trials

Live updates directly from PubMed Research

Impact of telemonitoring systems in cancer care: a systematic review

This systematic review evaluates the impact, usability, technical performance and adherence of telemonitoring systems in adult cancer care. This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Peer Review of Electronic Search Strategies guideline. PubMed, MEDLINE and CINAHL were searched from June 2013 to March 2025. Search terms covered cancer care, telemonitoring systems, mobile health (mHealth), eHealth, health outcomes and evaluation tools....

Sep 4, 2026Read Abstract →

Modern possibilities for the diagnosis of voice disorders using computer acoustic analysis of voice and artificial intelligence

OBJECTIVE: The purpose of the review is to analyze modern approaches to the diagnosis of voice disorders using AI and acoustic analysis, as well as to evaluate their effectiveness and prospects for implementation in clinical practice.

Sep 4, 2026Read Abstract →

Effects of external diaphragm pacing on early pulmonary function recovery in invasive mechanically ventilated patients with acute exacerbation of chronic obstructive pulmonary disease complicated by respiratory failure

CONCLUSIONS: The integrated pulmonary rehabilitation strategy of EDP combined with early mobilization effectively improves diaphragm function in mechanically ventilated patients with AECOPD and respiratory failure, shortens the duration of mechanical ventilation and hospital stay, increases the weaning success rate, and promotes long term recovery of pulmonary function, exercise tolerance, and quality of life, with a favorable safety profile.

Sep 4, 2026Read Abstract →

Natural products targeting hepatitis B virus X protein and HBx-associated pathways in HBV-related hepatocellular carcinoma: mechanisms and therapeutic potential

CONCLUSION: Natural products represent a promising multi-target therapeutic strategy for HBV-related HCC by intervening in HBx-driven oncogenic processes. Future studies should focus on mechanistic validation, standardization of bioactive compounds, and well-designed clinical trials to support their translational application as adjunctive or alternative therapies.

Sep 4, 2026Read Abstract →

Esketamine vs. sufentanil for quality of recovery after outpatient gynecological surgery: a randomized clinical trial

CONCLUSION: Among patients undergoing sedation for outpatient gynecological procedures, esketamine did not significantly improve quality of recovery on POD1 compared to sufentanil.

Sep 4, 2026Read Abstract →

Nano-Magnetism for Precision Neuroscience: Biohybrid Magnetoelectric Nanocarriers as Next-Generation Neural Drug Delivery Platforms

Neuroscience is making tremendous progress toward precision medicine, with nanotechnology playing a critical role in overcoming hurdles to successful brain medication delivery. Nano magnetism, namely biohybrid magnetoelectric nanocarriers (MENs), has emerged as a potential method for targeted and non-invasive medication delivery in neurological illnesses. These nanocarriers possess magnetoelectric properties, enabling stimulus-responsive drug release that is externally controlled. This allows...

Sep 4, 2026Read Abstract →

Traditional Chinese Medicine for Diabetic Cardiomyopathy: Multitarget Mechanisms and Translational Potential

CONCLUSION: TCM provides an innovative therapeutic strategy for DCM by simultaneously intervening in cascaded pathogenic pathways that single-target drugs fail to address adequately. Despite solid preclinical efficacy support, sufficient clinical verification is absent. Conducting high-quality translational research and multicenter randomized controlled trials is critical to translate laboratory outcomes into clinical practice and integrate TCM into standardized DCM treatment regimens.

Sep 4, 2026Read Abstract →

The Effect and Potential Pharmacological Mechanism of Tauroursodeoxycholic Acid for Spinal Cord Injury: A Systematic Review and Network Pharmacology

CONCLUSION: TUDCA can enhance neuronal autophagy and inhibit inflammatory factor expression, reducing inflammatory response and suppressing neuronal apoptosis in SCI. Due to the limited number and uneven quality of included studies, further laboratory studies and validation in clinical trials are necessary to clarify the neuroprotective effect of TUDCA.

Sep 4, 2026Read Abstract →

Signaling Pathways and Medicinal Properties of Quercitrin: A Review

CONCLUSION: Preclinical evidence supports QC as a multi-target signaling modulator with promising therapeutic potential. However, its clinical translation remains limited by insufficient pharmacokinetic data and the absence of well-designed human studies. Future standardized pharmacokinetic investigations and clinical trials are warranted to establish its efficacy and safety.

Sep 4, 2026Read Abstract →

HAND-IN (hand function after neuromodulation and intensive training in children with cerebral palsy): study protocol for a randomized, triple-blind, controlled trial with embedded implementation and cost-effectiveness analyses

AIM: The following clinical trial protocol aims to investigate the additional effects of bilateral transcranial direct current stimulation (tDCS) combined with constraint-induced movement therapy (CIMT) compared to CIMT alone in children and adolescents with spastic hemiparetic cerebral palsy.

Sep 4, 2026Read Abstract →

Extracorporeal CO<sub>2</sub> elimination for acute exacerbation of severe COPD requiring invasive mechanical ventilation: a randomized controlled trial (the X-COPD trial)

CONCLUSIONS: In this prematurely terminated trial, ECCO₂R-facilitated early extubation using a device with a capacity to eliminate more than 50% of the average CO(2) production, was associated with a shorter duration of invasive mechanical ventilation. Numerical trends favored ECCO(2)R across several secondary outcomes, although interpretation is limited by premature termination and the very small sample size. Adequately powered multicenter trials are warranted.

Sep 4, 2026Read Abstract →

The effect of communication skills-focused psychoeducation on subjective well-being of caregivers of individuals with schizophrenia: a three-arm randomized controlled trial

CONCLUSIONS: These findings show that both interventions are effective in enhancing caregivers' SWB, with CSFP providing longer-lasting effects. Future studies should further examine the effectiveness of these interventions and explore how they can be adapted to different groups. Additionally, integrating CSFP into psychosocial and rehabilitation programs could be beneficial in reducing caregiver burden and improving care outcomes.

Sep 4, 2026Read Abstract →

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

CONCLUSION: PAVF-QoL-14 provides a concise, validated, and disease-specific measure of quality of life for pouch-related fistula and shows strong potential for use in clinical practice and clinical trials.

Sep 4, 2026Read Abstract →

Optimized surgical treatment and study management for oncology patients in East Saxony (MISSION4Sax): study protocol of a multicentre pilot study

CONCLUSION: Strengthening cancer care infrastructure, interdisciplinary cooperation, and digital systems may support equitable access to high-value care in rural regions. The proposed tumour board, patient pathways, and trained staff may improve care quality and collaboration across sectors.

Sep 4, 2026Read Abstract →

Effect of a sodium fluoride rinse on the composition of early oral biofilms formed in situ on enamel and dentine

CONCLUSIONS: NaF rinse induces subtle species-level changes in early biofilms formed on enamel and dentine, while overall community diversity and dominant genera remain stable.

Sep 4, 2026Read Abstract →