clinical trials

Live updates directly from PubMed Research

Acceptability and efficacy of a smartphone intervention informed by interpersonal psychotherapy for perinatal mental health: A randomized controlled trial

CONCLUSIONS: The smartphone application was highly acceptable. While no significant differences in depressive symptoms were observed during pregnancy, differences favoring the intervention group were observed at 1 month postpartum. An IPT-informed smartphone intervention may represent a promising approach to perinatal mental health support.

Sep 24, 2026Read Abstract →

Adjuvant treatments for stage I breast cancers of one centimeter or less

PURPOSE OF REVIEW: The increasing detection of subcentimetric breast cancers (BC) through widespread implementation of mammographic screening has raised important questions regarding the optimal management of patients with stage I tumors measuring ≤1 cm in the adjuvant setting. Although these tumors exhibit an overall excellent prognosis, outcomes are heterogeneous and influenced by biological factors and patients characteristics. This review summarizes current evidence on adjuvant systemic...

Sep 24, 2026Read Abstract →

Analysis on principles of acupoint selection and characteristics of stimulation parameters based on randomized controlled trials of electroacupuncture for dysfunction after ischemic stroke

CONCLUSIONS: Among the included RCTs of electroacupuncture for motor dysfunction after ischemic stroke, acupoint selection is characterized as a certain of centrality, stability and diversity. The stimulation parameters of electroacupuncture exhibit significant heterogeneity and are not reported in accordance with the relevant guidelines. In the future, based on the clarification of different functional subtypes, it needs to enhance the quantification and standardized reporting of the...

Sep 24, 2026Read Abstract →

Effectiveness evaluation of heat-sensitive moxibustion self-management in community patients with essential hypertension： a randomized controlled trial

CONCLUSIONS: Heat-sensitive moxibustion self-management can reduce systolic blood pressure, improve antihypertensive effective rate, and alleviate hypertension-related symptoms and quality of life in community patients with essential hypertension, with favorable safety and compliance. These findings suggest that heat-sensitive moxibustion can be promoted as an adjunctive management strategy for essential hypertension in community settings.

Sep 24, 2026Read Abstract →

Acupuncture and biological resilience

This paper systematically elaborates the theories of stress, biological resilience and hormesis. Mild low-dose stress induces organismic overcompensation via preconditioning, activates nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant, autophagy, DNA repair and other pathways, and presents an inverted U-shaped biphasic dose-response relationship. Preconditioning is categorized into local and remote types, which exerts long-term protective effects on systemic organs via...

Sep 24, 2026Read Abstract →

Update on Pediatric asthma management: Recent advances

Asthma remains the commonest chronic pediatric respiratory disease and a major cause of childhood morbidity worldwide. Recent advances in pediatric asthma management shift the focus from symptom relief alone towards early control of airway inflammation, exacerbation prevention, and personalizing biomarkers to target biologics. This review highlights the growing role of anti-inflammatory reliever [AIR] therapy and maintenance-and-reliever therapy [MART], both of which incorporate inhaled...

Sep 24, 2026Read Abstract →

Progression-free survival and objective response rate as a surrogate end point for overall survival in metastatic renal cell carcinoma: A systematic review and meta-analysis

The objective of this systematic review and meta-analysis was to evaluate the validity of progression-free survival (PFS) and the objective response rate (ORR) as surrogate end points for overall survival (OS) in randomized controlled trials (RCTs) of metastatic renal cell carcinoma. The MEDLINE, Embase, and Cochrane CENTRAL databases were searched from inception to June 10, 2025. Associations between treatment effects on OS, PFS, and ORR were assessed using Pearson correlation coefficients (r)....

Sep 24, 2026Read Abstract →

Toward a Phase-Based Biological Stratification of Autism Spectrum Disorder: A Neuroinflammatory Developmental Framework

Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous neurodevelopmental condition arising from diverse genetic, epigenetic, and environmental influences. Increasing evidence suggests that immune dysregulation and sustained neuroinflammatory mechanisms contribute to the pathophysiology of a biologically defined subgroup of individuals with ASD. However, the temporal evolution of these processes and their relationship to clinical heterogeneity remain poorly understood. We...

Sep 24, 2026Read Abstract →

Gabapentin as an add-on analgesic to morphine in paediatric patients with chronic pain

CONCLUSIONS: A weight-banded dosing regimen results in consistent exposure to gabapentin and morphine across different age groups while ensuring acceptable safety margins. In addition, these results offer a rational basis for future clinical trials aiming to reduce opioid burden and optimize pain control in children.

Sep 24, 2026Read Abstract →

Clinically Meaningful Within-Patient Change in Core Attention-Deficit/Hyperactivity Disorder Symptoms in Children and Adolescents Treated With Centanafadine: Results From Two Phase 3 Randomized Clinical Trials

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is characterized by core symptoms of inattention, hyperactivity, and impulsivity that are persistent and can interfere with daily functioning. Centanafadine is a norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) and cental nervous symstem simulant recently FDA approved for the treatment of ADHD in both adult and pediatric patients. This secondary analysis explores the efficacy of centanafadine for the treatment of ADHD...

Sep 24, 2026Read Abstract →

A Prospective Comparison of Ultrasound-Guided Ankle Versus Popliteal Nerve Blocks for Elective Forefoot Surgery in a UK Podiatric Surgery Unit

CONCLUSIONS: Both ankle and popliteal blocks provided effective perioperative anaesthesia for elective forefoot surgery. Popliteal blocks offered longer analgesia, whereas ankle blocks showed a trend towards earlier mobilisation. Although limited by sample size and Type II error risk, these findings provide baseline data to inform future adequately powered studies and contribute evidence from UK podiatric day-case practice that may have relevance to wider day-case foot surgery.

Sep 24, 2026Read Abstract →

Corneal Opacification: Diagnosis, Incidence, and Strategies for Keratoplasty

CONCLUSION: Modern methods of keratoplasty enable targeted transplantation of only the affected corneal layers. As a result, postoperative complications are less common, and the transplants survive longer.

Sep 24, 2026Read Abstract →

Surgical Implantation of Revakinagene Taroretcellwey for the Treatment of Macular Telangiectasia Type 2: Technique and Surgical Pearls

Macular telangiectasia type 2 (MacTel), a bilateral, neurodegenerative disease associated with photoreceptor loss, often leads to progressive scotomas, metamorphopsia, and impaired reading function. Revakinagene taroretcel-lwey, a Food and Drug Administration (FDA)-approved encapsulated cell-based therapy for adults with MacTel, is surgically inserted into the vitreous cavity and provides sustained intraocular delivery of recombinant human ciliary neurotrophic factor (CNTF). Results from two...

Sep 24, 2026Read Abstract →

Involving a black woman patient and public involvement group in maternal health methodology research: learning from the PROMISE Study

CONCLUSIONS: Conceptually, the study positions inclusive PPI with Black women as a methodological necessity that reshapes research design, interpretation, and implementation. Alongside our reflections supported by the GRIPP2 framework, we describe practical approaches to implementing inclusive PPI processes in methodology research.

Sep 23, 2026Read Abstract →

The role of climate change education on awareness, anxiety, and hope among pregnant women: a randomized controlled study

CONCLUSION: The findings of this study demonstrate that climate change education is an effective intervention that significantly influences awareness, anxiety, and hope levels among pregnant women. These results suggest that structured educational programs for pregnant women may serve as a valuable tool in enhancing environmental awareness and supporting psychological well-being.

Sep 23, 2026Read Abstract →