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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

clinical trials

Live updates directly from PubMed Research

Population pharmacokinetic modeling of abacavir in HIV-exposed neonates and children with HIV-1 using data from the IMPAACT 2019 and PETITE studies

Abacavir (ABC) is one of the primary HIV nucleoside reverse transcriptase inhibitors used in pediatric antiretroviral therapy, yet optimal dosing in neonates and infants is challenging because of rapid developmental changes that influence its pharmacokinetics (PK). In this work, a previously developed pediatric population pharmacokinetic (PopPK) model for ABC was refined to extend its applicability to neonates and young infants by incorporating maturation-related processes and newly available...

Nov 3, 2026Read Abstract →

Full-Service Mobile Food Markets and Dietary Quality in Low-Income Housing Communities: A Randomized Clinical Trial

CONCLUSIONS AND RELEVANCE: In this study, satisfaction with the mobile market was high, but the mobile market did not improve diet quality or most outcomes examined. The mobile market was associated with a meaningful sodium reduction that could improve population-level health.

Nov 3, 2026Read Abstract →

Leadless Cardiac Resynchronization Results in Left Ventricular Reverse Remodeling: A Randomized Substudy of the SOLVE-CRT Study

No abstract

Nov 3, 2026Read Abstract →

Rifamycin use and gut microbial antibiotic resistance genes in cirrhosis: Results from a double-blind, placebo-controlled clinical trial

Antimicrobial resistance gene (ARG) carriage is associated with poor outcomes in patients with liver cirrhosis, which is worsened by repeated antibiotic exposure and hospitalizations. While the semi-synthetic rifamycin derivative, rifaximin, has recently been linked to ARG expansion preclinically, the effects of rifamycin SV MMX (RiVM) on the gut resistome remain unknown. We evaluated longitudinal resistome changes with RiVM in cirrhosis. The randomized, double-blind, placebo-controlled RIVET...

Nov 3, 2026Read Abstract →

Clinical trial evidence for disease-modifying therapies across the type 1 diabetes continuum: from presymptomatic stages to recent-onset disease

INTRODUCTION: Type 1 diabetes (T1D) can be identified before symptomatic insulin deficiency, creating an opportunity to intervene while meaningful beta-cell function remains.

Nov 3, 2026Read Abstract →

Anifrolumab use in children with refractory rheumatic conditions and elevated interferon signatures: A case report

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease where loss of immune tolerance and pathogenic autoantibody production lead to multisystem inflammation and damage. The type I interferon (IFN-I) signaling axis remains a critical immunologic pathway implicated in SLE and autoinflammatory conditions, such as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome (CANDLE). The shared IFN-mediated mechanism may provide a shared therapeutic...

Nov 3, 2026Read Abstract →

Phase 2 Trial of <sup>89</sup>Zr-Deferoxamine-Daratumumab for CD38-targeted Immuno-PET/CT Detection of Multiple Myeloma

Background Multiple myeloma (MM) imaging is currently suboptimal, which may limit patient care. Zirconium 89 (^(89)Zr) deferoxamine (DFO)-daratumumab is a novel CD38-targeted immuno-PET tracer. Purpose To compare ^(89)Zr-DFO-daratumumab PET/CT against standard-of-care fluorine 18 (^(18)F) fluorodeoxyglucose (FDG) PET/CT for detection of MM. Materials and Methods Participants with MM were accrued to this prospective phase 2 trial between March 2022 and July 2025. Standard-of-care ^(18)F-FDG...

Nov 3, 2026Read Abstract →

Added Value of Preoperative Contrast Enhanced Mammography in Staging of Malignant Breast Lesions (PROCEM): A Randomized Controlled Trial

Background Contrast-enhanced mammography (CEM) is increasingly used in breast cancer diagnostics; however, randomized trials assessing the added value of CEM in preoperative staging of breast cancer beyond digital mammography, digital breast tomosynthesis, and US are lacking. Purpose To assess the added value of CEM for preoperative breast cancer staging in a randomized controlled trial. Materials and Methods This prospective randomized controlled trial (Added Value of Preoperative Contrast...

Nov 3, 2026Read Abstract →

The Evolution of Medical Evidence Ecosystems

Medical knowledge accumulates exponentially, yet clinical implementation lags behind, creating a widening gap between science and practice. The hierarchical model positioning randomised clinical trials (RCTs) as the sole gold standard is undergoing transformation amid increasing regulatory recognition of real-world evidence (RWE). We apply Vanchurin's multilevel learning theory to interpret the medical evidence system as an adaptive ecosystem of complementary research methods. Within this...

Nov 3, 2026Read Abstract →

Exosomes in Traumatic Brain Injury: From Secondary Injury Mechanisms to Cell-Free Neurorepair

CONCLUSION: This study maps the global landscape of exosomes research in TBI and traces its evolution from pathogenesis to regenerative therapy. The United States and China stand out as complementary leaders, with American groups focusing on mechanisms and biomarkers and Chinese groups driving therapeutic translation. Future priorities for clinical translation include standardized isolation protocols, optimal dosing regimens, and rigorous clinical trials. Together, these findings offer a...

Nov 3, 2026Read Abstract →

Effects of Vitamin D 3 Supplementation on Glycaemic Parameters and Insulin Sensitivity in Pre-diabetic Adults: A Prospective Controlled Interventional Study

CONCLUSIONS: Vitamin D 3 supplementation significantly improved glycaemic control and insulin sensitivity in pre-diabetic adults, supporting its role as a safe, cost-effective adjunct to lifestyle modification in pre-diabetes management.

Nov 3, 2026Read Abstract →

Comparison of Traumatic Complications following Prostate Biopsy in Men with Lower Urinary Tract Symptoms Due to Prostate Disease Using Biopty Gun versus Semiautomatic Needle

CONCLUSION: The two devices did not exhibit significant differences in terms of pain or bleeding complications when used for prostate biopsy.

Nov 3, 2026Read Abstract →

A Comparative Study of the Efficacy and Safety of Two Misoprostol Regimens for Labour Induction at Term in Delta State: A Two-centre Triple-blind Randomised Controlled Trial

CONCLUSION: This study demonstrated comparable efficacy between hourly titrated oral misoprostol and four-hourly VM for labour induction. However, hourly titrated oral misoprostol exhibited a more favourable safety profile, as regards abnormal uterine contractions, foetal heart rate patterns and caesarean section rate.

Nov 3, 2026Read Abstract →

Visual Perceptual Learning Based on Adaptive Contrast Detection Training Enhances Vision and Contrast Sensitivity in Diabetic Retinopathy

CONCLUSIONS: The results reveal significant plasticity in the visual system in DR and suggest that contrast detection training may extend to motion perception tasks. Our study provides additional support for VPL as a potential treatment for DR.

Nov 3, 2026Read Abstract →

Virtual Reality Sickness and Safety During Use of a Purpose-Built Seated Virtual Reality System in Clinical Rehabilitation: Retrospective Single-Arm Cohort Study

CONCLUSIONS: In this real-world dataset, recorded VR sickness was uncommon and mostly mild with a purpose-built seated VR rehabilitation system, and no serious adverse events or medically attended VR sickness were reported in PMS. Whereas earlier work mainly tested individual design features under controlled conditions, this study documents an integrated multisensory design at scale in routine practice. Because it was uncontrolled and applied all features together, it cannot establish causality,...

Nov 3, 2026Read Abstract →