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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

clinical trials

Live updates directly from PubMed Research

The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications

Obesity significantly increases the risk of developing other chronic diseases and shortens the life expectancy by 5 to 8 years. Childhood obesity is particularly prominent as 80% of teenagers with obesity have shown it to persist into adulthood. With reference to the development of adult medication, the present review summarises the recent research progress in the development of pediatric anti-obesity drugs. The current management guidelines support the use of medication for adolescents aged 12...

Oct 14, 2026Read Abstract →

Closing the diagnostic gap in transthyretin cardiac amyloidosis: red flags, modern imaging, and emerging therapies

Transthyretin cardiac amyloidosis (ATTR-CM) is an increasingly recognized, treatable, and still underdiagnosed cause of heart failure with preserved ejection fraction (HFpEF) and unexplained left ventricular hypertrophy in older adults, with a typical diagnostic delay of several years. We conducted a narrative review with a systematic literature search of PubMed and Embase (January 2000 to June 2026) using database-specific controlled vocabulary and free-text terms related to ATTR...

Oct 14, 2026Read Abstract →

Beyond vitamin D: integrating nuclear receptor signaling networks in periodontal health and disease

Vitamin D receptor (VDR) signaling has been studied extensively in periodontology, yet the broader nuclear receptor superfamily remains underexplored. We examined the roles of four nuclear receptor family members: VDR, peroxisome proliferator-activated receptor gamma (PPAR-γ), retinoid X receptor alpha (RXR-α), and farnesoid X receptor (FXR) in periodontal health and disease across the continuum from gingival health through gingivitis to periodontitis. However, most functional and mechanistic...

Oct 14, 2026Read Abstract →

The role of sitagliptin in modifying metabolic, hormonal and clinical parameters in polycystic ovarian syndrome patients: a randomized controlled trial

CONCLUSION: Sitagliptin has potential impact on the hormonal, metabolic and clinical aspects of PCOS, and an exploratory effect on reproductive function. This makes it a potentially promising option for managing this complex condition.

Oct 14, 2026Read Abstract →

Controlled deep breathing technique intervention effects on resting EEG, subjective psychological distress, and executive function performance in young adults

Controlled breathing techniques have been widely investigated for their role in emotional regulation; however, their effects on resting-state neural oscillatory activity and psychological distress remain insufficiently characterized. The present study examined whether a Controlled Deep Breathing Technique (CDBT) intervention modulates resting-state electroencephalographic (EEG) activity and subjective psychological distress in healthy adults. Forty healthy adults (ages 18 to 40 years) were...

Oct 14, 2026Read Abstract →

Modulating inflammatory cytokines through acupuncture: Evidence from a systematic review

Evidence shows the positive effects of acupuncture on the modulation of cytokines. However, findings are conflicting. The present systematic review aimed to clarify the effects of acupuncture on pro- and anti-inflammatory cytokines in adults. Five databases, including Scopus, PubMed, Web of Science, Embase, and Cochrane Library, were searched without language restrictions until July 1, 2024. Clinical trials that examine the effects of manual acupuncture on at least one of the inflammatory...

Oct 14, 2026Read Abstract →

Contemporary Classification and Diagnostic Pathways for Common Gingival and Alveolar Ridge Lesions

Oral lesions can be observed in different locations in the oral cavity, including periodontal supporting structures, gingiva, and alveolar ridge. Ranging from benign to potentially malignant lesions, these lesions can be described from various perspectives, including duration, size, origin, number, and clinical characteristics. Early diagnosis of these lesions can highly affect treatment procedures and outcomes, while preserving tooth-supporting tissues. This review aimed to introduce a decision...

Oct 14, 2026Read Abstract →

Efficacy and specific toxicity profiles of GPRC5D- versus BCMA-targeted bispecific antibodies in relapsed/refractory multiple myeloma: a meta-analysis of clinical trials and real-world studies

CONCLUSION: Bispecific antibodies demonstrate clear antimyeloma activity in RRMM. BCMA×CD3-directed therapy is mainly related to infection and hematological toxicity, whereas GPRC5D×CD3-directed therapy is distinguished by epithelium-related toxicity, although severe events are rare.

Oct 14, 2026Read Abstract →

Exploring the biomechanical mechanisms of neuromuscular joint facilitation intervention in patients with knee osteoarthritis: a finite element analysis

INTRODUCTION: Knee osteoarthritis (KOA) causes joint pain and gait disorders in older adults. Exercise is an effective non-pharmaceutical therapy. Neuromuscular joint facilitation (NJF) improves knee joint function by combining neuromuscular facilitation with intra-articular joint motion; however, its biomechanical mechanism remains unclear. Finite element analysis, the mechanisms by which two NJF movement patterns-knee extension with lateral tibial rotation and knee flexion with medial tibial...

Oct 14, 2026Read Abstract →

The Resection Ability of Low-power Pure-cut Hot Snare Polypectomy for Nonpedunculated Colorectal Polyps Smaller Than 10 mm: A Single-center Prospective Study

CONCLUSIONS: LPPC-HSP demonstrated acceptable vertical resection capability. LPPC-HSP may be applicable for colorectal polyps smaller than 10 mm with potential malignancy, providing resection depth comparable to that of conventional electrocautery-based methods. Trial Registration: University Hospital Medical Network Clinical Trials Registry: UMIN000054732.

Oct 14, 2026Read Abstract →

Ilioinguinal-Transversus Abdominis Plane (I-TAP) Block with Liposomal Bupivacaine for Analgesia After Cesarean Delivery: A Randomized Controlled Trial

CONCLUSION: Compared with TAP block plus epidural hydromorphone and epidural hydromorphone alone, liposomal bupivacaine I-TAP block combined with epidural hydromorphone significantly reduced post-cesarean PCIA sufentanil requirements, improved postoperative analgesia and recovery quality, and increased maternal satisfaction without evidence of increased adverse events. This technique may provide a safe and effective option for implementation within multimodal analgesic strategy after cesarean...

Oct 14, 2026Read Abstract →

Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial

CONCLUSION: In elderly patients undergoing laparoscopic colorectal cancer surgery, QLB-LSAL combined with low-dose esketamine improved the prespecified day-3 recovery endpoint and reduced early postoperative pain and opioid use compared with esketamine alone; any anxiolytic effect was not confirmed after multiplicity adjustment. Trial registration: ChiCTR2400082301.

Oct 14, 2026Read Abstract →

Gut microbial dynamics and antibiotic resistance during rifaximin therapy in severe cirrhosis: a ProPILA-Rifax ancillary study

INTRODUCTION: Increasing evidence implicates gut dysbiosis in the pathophysiology of advanced cirrhosis. This is an ancillary study of the ProPILA-Rifax trial (NCT03069131), which evaluated rifaximin (RFX) as primary prophylaxis of spontaneous bacterial peritonitis (SBP) in patients with severe cirrhosis. Although the combined use of RFX and lactulose is effective in preventing recurrent hepatic encephalopathy (HE), its longitudinal impact on microbial communities and antibiotic resistance...

Oct 14, 2026Read Abstract →

Serum metabolomics identifies ganglioside dysregulation and pyruvate dehydrogenase complex-related metabolic disturbances in pediatric drug-resistant epilepsy

CONCLUSION: The observed alterations in S-acetyldihydrolipoamide, HE-TDP, and SAM support their further investigation as candidate monitoring biomarkers and as metabolites potentially involved in therapeutically relevant pathways in DRE. The alterations observed in HE-TDP, SAM, GM2, PS, and PE generate the hypothesis that pathways involving thiamine-dependent energy metabolism, methylation, ganglioside metabolism, and mitochondrial membrane function may be relevant to DRE. However, the present...

Oct 14, 2026Read Abstract →

Dacomitinib With or Without Dose Titration in Treatment-Naive Advanced <em>EGFR</em>-Mutated NSCLC - Primary Analysis of the ATORG-003 Phase 2 Trial

CONCLUSION: ATORG-003 prospectively revealed that dacomitinib with dose titration is a viable strategy in advanced EGFR-mutated NSCLC, maintaining efficacy while improving tolerability. Dacomitinib has substantial intracranial activity and high rates of T790M resistance, making it suitable for sequential treatment approaches.

Oct 14, 2026Read Abstract →