Live updates directly from PubMed Research
CONCLUSIONS AND RELEVANCE: Among patients with PHN in this study, electroacupuncture provided a statistically significant reduction in pain severity, increased responder rates, and improved pain-related functional outcomes. These benefits suggest that electroacupuncture may be a useful nonpharmacological option for integrated management of PHN.
CONCLUSIONS AND RELEVANCE: This meta-analysis provides a comprehensive synthesis of evidence from randomized clinical trials comparing HD-IIV with SD-IIV in older adults. HD-IIV was associated with improved protection against hospitalization outcomes, from LCI to all causes, but was not associated with improvement of all-cause mortality. These findings may inform decision-makers in developing vaccine recommendations and policies.
CONCLUSIONS AND RELEVANCE: This stepped-wedge cluster randomized clinical trial suggests that neurological teleconsultations in general practice may have helped triage patients (eg, to other specialists or hospitals) and therefore contributed to improved medical care, particularly in structurally underserved areas; however, an immediate reduction in the use of secondary care was not found. The inability to blind GPs to the randomization may have introduced selection effects, which should be...
No abstract
CONCLUSIONS AND RELEVANCE: In this longitudinal study, a plasma-based biological staging model incorporating %p-tau217 and eMTBR-tau243 showed strong concordance with PET-based staging, correlated with clinical severity and biomarker progression, and aligned with neuropathological categorization. This scalable, minimally invasive approach could facilitate broader implementation of biological staging in clinical practice and could enhance participant selection for disease-modifying treatments and...
CONCLUSION: These results supported the approval of body weight-based dosing regimens of GLE and PIB in children (< 45 kg) infected with any HCV genotype.
CONCLUSION: This study represents the first AI-driven AGHD Data Mart and demonstrates the feasibility of constructing the Data Mart from routine clinical data. This approach offers a complementary framework for structured RWD extraction and may support future longitudinal analyses and AI-based clinical support in AGHD.
CONCLUSIONS: Limited conclusions can be drawn from these five studies because of non-standardized cognitive assessments, small sample sizes, and methodological variability. However, overall, this scoping review provides evidence that treatment of orthostatic hypotension might have a cognitive benefit in certain populations. Further observational studies and clinical trials are warranted to better elucidate whether combinations of midodrine, droxidopa, and fludrocortisone will work in specific...
Remote biospecimen collection (RBSC), such as home-based HIV testing and self-collection of dried blood spots (DBS) to assess adherence to antiretroviral drug regimens, has become an important tool to support clinical research because it can facilitate participant reach, lower participant burden, and reduce discomfort with attending research visits in clinic spaces. RBSC is common in sexual health clinical intervention trials to assess the impact of an intervention or program on primary and...
A two-and-a-half-day workshop on regulatory and ethical issues in first-in-human (FIH) clinical trials in India was held at the Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, on 7-9 November 2024, under the aegis of the Indian Council of Medical Research (ICMR) Phase I Network. The workshop brought together regulators, academic investigators, and industry representatives to examine the evolving regulatory landscape of early phase trials in India and the...
Atopic dermatitis (AD) is associated with a significant physical, psychological, social and economic burden and a decreased quality of life. There is a relationship between disease burden and the level of disease severity and control. The burden of AD largely depends on skin lesions, itch and sleep disturbances, although other aspects also play a role. Even though treat-to-target approaches have been proposed for AD in recent years, studies showed that many patients with AD continue to perceive...
PURPOSE OF THE REVIEW: Pericarditis - the inflammation of the pericardial sac - has a generally benign course, although recurrences may occur in 15-30% of patients within 18 months, even after an initial uncomplicated course. For a long time, the scarcity of animal models has limited a deeper understanding of the pathophysiology of pericarditis.
CONCLUSION: Epithelial alarmins represent critical upstream drivers of asthma pathogenesis, orchestrating diverse inflammatory pathways that determine disease endotypes and severity. Therapeutic targeting of TSLP, IL-33, and IL-25 offers a paradigm shift from downstream cytokine inhibition to source-directed intervention, with potential to reduce exacerbations, prevent airway remodelling, and improve disease control across different asthma phenotypes. The success of anti-TSLP therapy and ongoing...
Chronic heart failure causes significant morbidity and mortality worldwide. Mineralocorticoid receptor antagonists are pivotal in the management of heart failure with reduced ejection fraction, as demonstrated in large outcomes trials that tested the efficacy of the steroidal mineralocorticoid receptor antagonists, spironolactone and eplerenone. There is still debate regarding their use in the management of heart failure with mildly reduced ejection fraction or heart failure with preserved...
CONCLUSION: Publication of large core thrombectomy trials was associated with substantial increases in endovascular thrombectomy use in large-core stroke, including among patients with very low ASPECTS, with a non-significant increase in symptomatic intracranial hemorrhage and a decline in favorable functional outcomes. Clinician adherence to baseline severity considerations (ASPECTS, age, and premorbid function) appears appropriate. These findings demonstrate the safe and rapid translation of...
Blyss
Your Health Guide · The Health Thread
⚕️ Not medical advice. Always consult a qualified doctor.