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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

Pagoda-Inspired Microneedles for Multiphase Coverage Wound Healing.

Researchers

Lu Fan, Li Wang, Wenzhao Li, Danna Liang, Hong Chen, Chenjie Yu, Yuanjin Zhao

Abstract

Microneedle patches are considered as an attractive technology for wound treatment. Current researches are devoted to enhancing the structure and functionality of microneedles to cover multiphase for wound healing. Here, we present a desired quaternized chitosan-coated pagoda-inspired microneedle (QPDMN) patch loaded with diverse drugs to treat wounds. The QPDMN tips are comprised of a bottom layer loading vascular endothelial growth factor (VEGF) and a top layer containing antimicrobial peptides (AMPs), as well as with the outer surface coated with quaternized chitosan (QCS). When applied, QCS could firstly contact wounds and rapidly promote blood clotting. Subsequently, AMPs released from top needles could remarkably inhibit bacterium growth, while VEGF released from bottom tips effectively facilitate tissue regeneration. Animal experiments have further proved that the QPDMN system has rapid hemostasis, enhanced angiogenesis, anti-inflammation and collagen deposition performances, coordinating the different phases of wound healing. Thus, we believe that the pagoda-like microneedles could be an excellent multiphase-coverage therapeutic agent in clinic wound healing.
Source: PubMed (PMID: 43000206)View Original on PubMed