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•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

Clinical Trials: A Call for Collaboration Between Pediatrics and Internal Medicine.

Researchers

Rona M Smith, William E Smoyer, Louise Oni, Anne Rohall, Cal H Robinson, Lynne Yao, David Fuller, Rulan S Parekh, Kevin Fowler, Mark D Lim, Howard Trachtman

Abstract

The conduct of randomized clinical trials (RCTs) in kidney disease among children and older youth has historically been challenging, reflecting, in part, the relative rarity of the conditions. This has resulted in a 13-year gap between the granting of approval for novel therapies in adults and their subsequent approval in children and created a significant lag in access to drugs in pediatrics that treat kidney disorders. One contributing factor that has been neglected is the operational barriers created by cultural and institutional structures that (1) divide pediatric from adult clinical nephrology services and (2) ignore the challenge for older pediatric patients who enroll in RCTs and straddle the boundary between pediatrics and internal medicine. In this Perspective, we offer potential approaches to overcome the human, logistical, and administrative impediments to meaningful collaboration between pediatric and adult nephrologists with the objective of promoting the timely initiation and completion of RCTs in pediatric nephrology.
Source: PubMed (PMID: 42966595)View Original on PubMed