[Herbal cake-separated moxibustion combined with <i>Bufei Tongluo</i> decoction in treatment of diabetes-induced pulmonary fibrosis of <i>qi</i>-<i>yin</i> deficiency with blood stagnation: a randomized controlled trial].

Abstract

To observe the clinical efficacy of herbal cake-separated moxibustion combined with <i>Bufei Tongluo</i> decoction on diabetes-induced pulmonary fibrosis (DiPF) of <i>qi</i>-<i>yin</i> deficiency with blood stagnation. A total of 102 DiPF patients were randomly divided into an observation group (51 cases, 1 case dropped out) and a control group (51 cases, 1 case was eliminated and 1 case dropped out). In the control group, <i>Bufei Tongluo</i> decoction was administered, one dose per day; and in the observation group, herbal cake-separated moxibustion was operated at Danzhong (CV17) and bilateral Feishu (BL13), Gaohuang (BL43), Zusanli (ST36), etc. on the basis of the treatment in the control group, once every two days, three times a week. The interventions in the two groups were operated continuously for 8 weeks. The TCM symptom score, high-resolution CT (HRCT) score, the 6-minute walk test (6MWT), the indexes of pulmonary function test (the percentage of measured values of the total lung capacity [TLC], forced vital capacity [FVC], and lung carbon monoxide diffusion capacity [DLCO] relative to predicted values), and the levels of serological markers (hydroxyproline [Hyp], interleukin-10 [IL-10] and transforming growth factor-&#x3b2; [TGF-&#x3b2;]) were compared before and after treatment in the twogroups. The clinical efficacy and safety of both groups were evaluated. After treatment, the scores of each symptom (dry cough with little phlegm, shortness of breath and fatigue, dry mouth and throat, feverish sensations in the palms and soles, and stabbing pain in the chest and hypochondriac region) and the total scores of TCM syndrome, HRCT scores, and the levels of serum Hyp, IL-10, and TGF-&#x3b2; in both groups decreased in comparison with those before treatment (<i>P</i>&lt;0.05); and the scores of dry cough with little phlegm, shortness of breath and fatigue, stabbing pain in the chest and hypochondriac region, the total score of TCM syndrome, HRCT score, the levels of serum IL-10 and TGF-&#x3b2; in the observation group were lower than those in the control group (<i>P</i>&lt;0.05). After treatment, the 6MWT and the percentages of measured values of TLC, FVC and DLCO relative to predicted values in both groups increased in comparison with those before treatment (<i>P</i>&lt;0.05); and the percentages of measured values of TLC, FVC and DLCO relative to predicted values in the observation group were higher than those in the control group (<i>P</i>&lt;0.05). The clinical efficacy of the observation group was superior to the control group (<i>P</i>&lt;0.05). The total effective rate in the observation group was 98.0% (49/50), without statistically significant difference compared with the control group (87.8% [43/49], <i>P</i>&gt;0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (<i>P</i>&gt;0.05). Herbal cake-separated moxibustion combined with <i>Bufei Tongluo</i> decoction can effectively alleviate clinical symptoms, improve pulmonary function, and reduce inflammatory response and fibrosis in DiPF patients of <i>qi</i>-<i>yin</i> deficiency with blood stagnation. <b>&#x76ee;&#x7684;&#xff1a;</b>&#x89c2;&#x5bdf;&#x9694;&#x836f;&#x997c;&#x7078;&#x8054;&#x5408;&#x8865;&#x80ba;&#x901a;&#x7edc;&#x6c64;&#x6cbb;&#x7597;&#x7cd6;&#x5c3f;&#x75c5;&#x80ba;&#x7ea4;&#x7ef4;&#x5316;&#xff08;DiPF&#xff09;&#x6c14;&#x9634;&#x4e24;&#x865a;&#x5939;&#x7600;&#x8bc1;&#x7684;&#x4e34;&#x5e8a;&#x7597;&#x6548;&#x3002; <b>&#x65b9;&#x6cd5;&#xff1a;</b>&#x5c06;102&#x4f8b;DiPF&#x6c14;&#x9634;&#x4e24;&#x865a;&#x5939;&#x7600;&#x8bc1;&#x60a3;&#x8005;&#x968f;&#x673a;&#x5206;&#x4e3a;&#x89c2;&#x5bdf;&#x7ec4;&#xff08;51&#x4f8b;&#xff0c;&#x8131;&#x843d;1&#x4f8b;&#xff09;&#x548c;&#x5bf9;&#x7167;&#x7ec4;&#xff08;51&#x4f8b;&#xff0c;&#x5254;&#x9664;1&#x4f8b;&#x3001;&#x8131;&#x843d;1&#x4f8b;&#xff09;&#x3002;&#x5bf9;&#x7167;&#x7ec4;&#x91c7;&#x7528;&#x8865;&#x80ba;&#x901a;&#x7edc;&#x6c64;&#x6cbb;&#x7597;&#xff0c;&#x6bcf;&#x65e5;1&#x5242;&#xff1b;&#x89c2;&#x5bdf;&#x7ec4;&#x5728;&#x5bf9;&#x7167;&#x7ec4;&#x6cbb;&#x7597;&#x7684;&#x57fa;&#x7840;&#x4e0a;&#xff0c;&#x5206;&#x522b;&#x4e8e;&#x81bb;&#x4e2d;&#x53ca;&#x53cc;&#x4fa7;&#x80ba;&#x4fde;&#x3001;&#x818f;&#x8093;&#x3001;&#x8db3;&#x4e09;&#x91cc;&#x7b49;&#x7a74;&#x65bd;&#x7528;&#x9694;&#x836f;&#x997c;&#x7078;&#xff0c;&#x9694;&#x65e5;1&#x6b21;&#xff0c;&#x6bcf;&#x5468;&#x6cbb;&#x7597;3&#x6b21;&#x3002;&#x4e24;&#x7ec4;&#x5747;&#x8fde;&#x7eed;&#x6cbb;&#x7597;8&#x5468;&#x3002;&#x5206;&#x522b;&#x4e8e;&#x6cbb;&#x7597;&#x524d;&#x540e;&#x6bd4;&#x8f83;&#x4e24;&#x7ec4;&#x60a3;&#x8005;&#x4e2d;&#x533b;&#x8bc1;&#x5019;&#x79ef;&#x5206;&#x3001;&#x9ad8;&#x5206;&#x8fa8;&#x7387;CT&#xff08;HRCT&#xff09;&#x79ef;&#x5206;&#x3001;6&#x5206;&#x949f;&#x6b65;&#x884c;&#x8bd5;&#x9a8c;&#xff08;6MWT&#xff09;&#x3001;&#x80ba;&#x529f;&#x80fd;&#x68c0;&#x6d4b;&#x4eea;&#x6307;&#x6807;[&#x80ba;&#x603b;&#x91cf;&#xff08;TLC&#xff09;&#x3001;&#x7528;&#x529b;&#x80ba;&#x6d3b;&#x91cf;&#xff08;FVC&#xff09;&#x3001;&#x80ba;&#x4e00;&#x6c27;&#x5316;&#x78b3;&#x5f25;&#x6563;&#x91cf;&#xff08;DLCO&#xff09;&#x5b9e;&#x6d4b;&#x503c;&#x5360;&#x9884;&#x8ba1;&#x503c;&#x7684;&#x767e;&#x5206;&#x6bd4;]&#x3001;&#x8840;&#x6e05;&#x6307;&#x6807;[&#x7f9f;&#x812f;&#x6c28;&#x9178;&#xff08;Hyp&#xff09;&#x3001;&#x767d;&#x7ec6;&#x80de;&#x4ecb;&#x7d20;-10&#xff08;IL-10&#xff09;&#x3001;&#x8f6c;&#x5316;&#x751f;&#x957f;&#x56e0;&#x5b50;-&#x3b2;&#xff08;TGF-&#x3b2;&#xff09;]&#x6c34;&#x5e73;&#xff0c;&#x5e76;&#x8bc4;&#x5b9a;&#x4e24;&#x7ec4;&#x60a3;&#x8005;&#x7684;&#x4e34;&#x5e8a;&#x7597;&#x6548;&#x548c;&#x5b89;&#x5168;&#x6027;&#x3002; <b>&#x7ed3;&#x679c;&#xff1a;</b>&#x6cbb;&#x7597;&#x540e;&#xff0c;&#x4e24;&#x7ec4;&#x60a3;&#x8005;&#x5404;&#x9879;&#x4e2d;&#x533b;&#x8bc1;&#x5019;&#xff08;&#x5e72;&#x54b3;&#x5c11;&#x75f0;&#x3001;&#x6c14;&#x77ed;&#x4e4f;&#x529b;&#x3001;&#x53e3;&#x5e72;&#x54bd;&#x71e5;&#x3001;&#x624b;&#x8db3;&#x5fc3;&#x70ed;&#x3001;&#x80f8;&#x80c1;&#x523a;&#x75db;&#xff09;&#x79ef;&#x5206;&#x548c;&#x603b;&#x79ef;&#x5206;&#x3001;HRCT&#x79ef;&#x5206;&#x53ca;&#x8840;&#x6e05;Hyp&#x3001;IL-10&#x3001;TGF-&#x3b2;&#x542b;&#x91cf;&#x5747;&#x8f83;&#x6cbb;&#x7597;&#x524d;&#x964d;&#x4f4e;&#xff08;<i>P</i>&lt;0.05&#xff09;&#xff1b;&#x89c2;&#x5bdf;&#x7ec4;&#x60a3;&#x8005;&#x5e72;&#x54b3;&#x5c11;&#x75f0;&#x3001;&#x6c14;&#x77ed;&#x4e4f;&#x529b;&#x3001;&#x80f8;&#x80c1;&#x523a;&#x75db;&#x79ef;&#x5206;&#x548c;&#x603b;&#x79ef;&#x5206;&#xff0c;HRCT&#x79ef;&#x5206;&#x53ca;&#x8840;&#x6e05;IL-10&#x3001;TGF-&#x3b2;&#x542b;&#x91cf;&#x4f4e;&#x4e8e;&#x5bf9;&#x7167;&#x7ec4;&#xff08;<i>P</i>&lt;0.05&#xff09;&#x3002;&#x6cbb;&#x7597;&#x540e;&#xff0c;&#x4e24;&#x7ec4;&#x60a3;&#x8005;6MWT&#x548c;TLC&#x3001;FVC&#x3001;DLCO&#x5b9e;&#x6d4b;&#x503c;&#x5360;&#x9884;&#x8ba1;&#x503c;&#x7684;&#x767e;&#x5206;&#x6bd4;&#x8f83;&#x6cbb;&#x7597;&#x524d;&#x5347;&#x9ad8;&#xff08;<i>P</i>&lt;0.05&#xff09;&#xff1b;&#x89c2;&#x5bdf;&#x7ec4;&#x60a3;&#x8005;TLC&#x3001;FVC&#x3001;DLCO&#x5b9e;&#x6d4b;&#x503c;&#x5360;&#x9884;&#x8ba1;&#x503c;&#x7684;&#x767e;&#x5206;&#x6bd4;&#x9ad8;&#x4e8e;&#x5bf9;&#x7167;&#x7ec4;&#xff08;<i>P</i>&lt;0.05&#xff09;&#x3002;&#x89c2;&#x5bdf;&#x7ec4;&#x4e34;&#x5e8a;&#x7597;&#x6548;&#x4f18;&#x4e8e;&#x5bf9;&#x7167;&#x7ec4;&#xff08;<i>P</i>&lt;0.05&#xff09;&#x3002;&#x89c2;&#x5bdf;&#x7ec4;&#x603b;&#x6709;&#x6548;&#x7387;&#x4e3a;98.0%&#xff08;49/50&#xff09;&#xff0c;&#x4e0e;&#x5bf9;&#x7167;&#x7ec4;&#xff08;87.8%&#xff0c;43/49&#xff09;&#x6bd4;&#x8f83;&#x5dee;&#x5f02;&#x65e0;&#x7edf;&#x8ba1;&#x5b66;&#x610f;&#x4e49;&#xff08;<i>P</i>&gt;0.05&#xff09;&#x3002;&#x4e24;&#x7ec4;&#x60a3;&#x8005;&#x4e0d;&#x826f;&#x53cd;&#x5e94;&#x53d1;&#x751f;&#x7387;&#x6bd4;&#x8f83;&#x5dee;&#x5f02;&#x65e0;&#x7edf;&#x8ba1;&#x5b66;&#x610f;&#x4e49;&#xff08;<i>P</i>&gt;0.05&#xff09;&#x3002; <b>&#x7ed3;&#x8bba;&#xff1a;</b>&#x9694;&#x836f;&#x997c;&#x7078;&#x8054;&#x5408;&#x8865;&#x80ba;&#x901a;&#x7edc;&#x6c64;&#x6cbb;&#x7597;&#x80fd;&#x591f;&#x6709;&#x6548;&#x6539;&#x5584;DiPF&#x6c14;&#x9634;&#x4e24;&#x865a;&#x5939;&#x7600;&#x8bc1;&#x60a3;&#x8005;&#x7684;&#x4e34;&#x5e8a;&#x75c7;&#x72b6;&#x3001;&#x80ba;&#x529f;&#x80fd;&#x3001;&#x708e;&#x75c7;&#x53cd;&#x5e94;&#x548c;&#x80ba;&#x7ea4;&#x7ef4;&#x5316;&#x7a0b;&#x5ea6;&#x3002;.