About Us
The Health Thread
Ethical Health Journalism
Live
🌍Urgent Alert: Deano's Pasta Recalls Ravioli Over Hidden Lobster Allergen Risk🌍Saratoga Chips Recall: Undeclared Soy Poses Allergy Risk🌍So Delicious Dairy-Free Frozen Dessert Recall: What Consumers Need to Know About Food Safety🌍Hidden Egg Allergen Prompts Whole Foods Cheese Recall🌍DR Congo Camp Residents Face Dire Conditions, Violence, and Ebola Threat🌍Urgent Alert: Deano's Pasta Recalls Ravioli Over Hidden Lobster Allergen Risk🌍Saratoga Chips Recall: Undeclared Soy Poses Allergy Risk🌍So Delicious Dairy-Free Frozen Dessert Recall: What Consumers Need to Know About Food Safety🌍Hidden Egg Allergen Prompts Whole Foods Cheese Recall🌍DR Congo Camp Residents Face Dire Conditions, Violence, and Ebola Threat
Research Watch
•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•स्क्रिनमा देखिने चुरोट: सुर्तीजन्य हानि न्यूनीकरण नीतिमा दक्षिण एसियाले अझै के छुटाइरहेको छ•नेपालमा पिसाब नलीको संक्रमण र एन्टिबायोटिक प्रतिरोधको बढ्दो संकट•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs

CAR T cells for autoimmune diseases: 2026 update of the EBMT-ISCT-JACIE practice harmonisation and consensus recommendations.

Researchers

Raffaella Greco, Fabian Müller, Aiden Haghikia, Franco Locatelli, Dimitrios Mougiakakos, Karin Tarte, Tobias Alexander, Nicoletta Del Papa, Andrea Doria, Christoph Heesen, Jörg Henes, Zora Marjanovic, Paolo A Muraro, Doron Rimar, Elisa Roldan, Fermin Sanchez-Guijo, Basil Sharrack, John A Snowden, Francesco Onida, Isabel Sánchez-Ortega, Marco Becilli, Agnès Bonnin, Fabio Ciceri, Krzysztof Kalwak, Bruce L Levine, Andreas Mackensen, Johanna Richter, Tuula Rintala, Annalisa Ruggeri, Ibrahim Yakoub-Agha, Georg Schett, Dominique Farge

Abstract

Autoimmune diseases are a heterogeneous group of chronic diseases characterised by loss of immune tolerance with substantial morbidity and mortality. Since 2021, chimeric antigen receptor (CAR) T cells have recently emerged as a promising treatment option for patients with severe, refractory autoimmune diseases. In 2024, an international expert panel from the European Society for Blood and Marrow Transplantation (EBMT), the International Society for Cell and Gene Therapy (ISCT), and the Joint Accreditation Committee of ISCT and EBMT (JACIE) released the first best-practice recommendations on CAR T cells for autoimmune diseases. Using the same consensus methodology, these living recommendations were updated thereafter. The 2026 consensus reviews current evidence and expert practices on CAR T cells for rheumatic, neurological, haematological, other autoimmune diseases, and paediatric indications, providing updated, expert-based recommendations on patient selection, diagnostic investigation, clinical management, follow up, and immune monitoring for each disease group. Unmet needs and future research priorities are also highlighted.
Source: PubMed (PMID: 42833234)View Original on PubMed