About Us
The Health Thread
Ethical Health Journalism
Live
🌍WHO Unveils New Guidelines to Revolutionize Filovirus Disease Care🌍Rapid Decentralized Testing Boosts Ebola Response in DR Congo Outbreak🌍Uganda's Strong Ebola Response Highlights Critical Need for Regional Unity🌍Global Debt Crisis: How National Finances Impact Children's Health and Future🌍Ebola Outbreak in DRC and Uganda: Understanding the Bundibugyo Strain and Global Response🌍WHO Unveils New Guidelines to Revolutionize Filovirus Disease Care🌍Rapid Decentralized Testing Boosts Ebola Response in DR Congo Outbreak🌍Uganda's Strong Ebola Response Highlights Critical Need for Regional Unity🌍Global Debt Crisis: How National Finances Impact Children's Health and Future🌍Ebola Outbreak in DRC and Uganda: Understanding the Bundibugyo Strain and Global Response
Research Watch
•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Frontline Perspectives on Nursing Leadership in Nepal•Protecting the Smallest Lungs from the Hidden Grip of RSV in Kathmandu•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"

New biomarkers for antibody-drug conjugates in lung cancer the pathologist's perspective.

Researchers

Véronique Hofman, Guylène Rignol, Baharia Mograbi, Marius Ilié, Mariona Riudavets, Fernando Lopez-Rios, Nicola Fusco, Umberto Malapelle, Sanjay Popat, Albrecht Stenzinger, David Planchard, Antonio Passaro, Simon Heeke, Solange Peters, Ignacio Ivan Wistuba, Fred R Hirsch, Paul Hofman

Abstract

Antibody-drug conjugates (ADC) as a new treatment modality have enabled novel, promising treatment options in lung cancer. However, biomarkers for the selection of appropriate treatments are still under development, posing novel challenges for tissue selection and development of companion diagnostics (CDx). In this review, we address the challenges and discuss best practice for fast, reliable and robust implementation of novel biomarkers in treatment selection of ADCs in lung cancer.
Source: PubMed (PMID: 42364305)View Original on PubMed