About Us
The Health Thread
Ethical Health Journalism
Live
🌍Ebola Spreads in Eastern DRC and Uganda: UNICEF Warns of Growing Threat to Children🌍Cholera Outbreak Intensifies in Borno, Nigeria: Urgent Health Response Underway🌍Burundi Bolsters Defenses Against Ebola Threat from Neighboring Nations🌍DR Congo Faces Dual Crisis: Food Insecurity Worsens Amidst Spreading Ebola Outbreak🌍Ebola Outbreak in DRC and Uganda: Navigating the Bundibugyo Challenge🌍Ebola Spreads in Eastern DRC and Uganda: UNICEF Warns of Growing Threat to Children🌍Cholera Outbreak Intensifies in Borno, Nigeria: Urgent Health Response Underway🌍Burundi Bolsters Defenses Against Ebola Threat from Neighboring Nations🌍DR Congo Faces Dual Crisis: Food Insecurity Worsens Amidst Spreading Ebola Outbreak🌍Ebola Outbreak in DRC and Uganda: Navigating the Bundibugyo Challenge
Research Watch
•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali Workers•Silent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child Abuse•The Heavy Burden of Bullying on Student Wellbeing in Nepal•The Emerging Landscape of Thyroid Health in Central Nepal•How a Recent Western Nepal Study is Redefining Anemia Diagnosis•How H. Pylori is Impacting the Health of Karnali’s High-Altitude Communities•Sweet Poison, Bitter Reality: The Unseen Diabetes Epidemic Among Nepal’s Youth•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali Workers•Silent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child Abuse

Estimated Effectiveness of 2024-2025 COVID-19 Vaccines in Adults.

Researchers

Ryan E Wiegand, Amanda B Payne, Josephine Mak, Sean Chickery, Sarah E Reese, Nicola P Klein, Shaun J Grannis, Toan C Ong, Elizabeth A K Rowley, Malini DeSilva, Kristin Dascomb, Stephanie A Irving, Ousseny Zerbo, John R Hansen, Lawrence Block, Karen B Jacobson, Brian E Dixon, Colin M Rogerson, Thomas J Duszynski, William F Fadel, Michelle A Barron, David Mayer, Catia Chavez, Duck-Hye Yang, Sarah W Ball, Charlene E McEvoy, Omobosola O Akinsete, Tamara Sheffield, Daniel Bride, Julie Arndorfer, Joshua Van Otterloo, Allison L Naleway, Karthik Natarajan, Morgan Najdowski, Allison Avrich Ciesla, Amber Kautz, Jennifer DeCuir, Ruth Link-Gelles

Abstract

Vaccine effectiveness (VE) estimates are needed to monitor the effect of updated COVID-19 vaccinations. To assess the effectiveness of 2024-2025 COVID-19 vaccines against medically attended COVID-19 among adults 18 years and older in the US. This case-control study with a test-negative design included patient encounters with a COVID-19-like illness discharge diagnosis code and a molecular or antigen SARS-CoV-2 test within 10 days before to 3 days after the encounter date, from September 5, 2024, to September 2, 2025. Encounters were captured in VISION (Virtual SARS-CoV-2, Influenza, and Other Respiratory Viruses Network), a multisite, electronic medical record-based network of health care systems, including 381 emergency department/urgent care (ED/UC) departments and 246 hospitals in 6 states. Vaccination with a 2024-2025 COVID-19 vaccine formulation (approved by the US Food and Drug Administration in August 2024) in the previous 7 to 299 days. Outcomes were COVID-19-associated ED/UC encounters, COVID-19-associated hospitalization, and COVID-19-associated critical illness (hospitalization with an intensive care unit admission or in-hospital death). Encounters with a positive molecular or antigen SARS-CoV-2 test result were classified as cases, and encounters with a negative molecular SARS-CoV-2 test result were classified as controls. The odds of 2024-2025 COVID-19 vaccination were compared among cases and controls, adjusting for confounders, with estimated VE calculated as (1 - adjusted odds ratio) × 100%. In 333 262 eligible ED/UC encounters (median [IQR] age of patients, 54 [35-72] years; 60% female) and 97 663 eligible hospitalizations among immunocompetent adults 18 years and older (median [IQR] age of patients, 72 [59-81] years; 53% female), estimated VE was 26% (95% CI, 23%-29%) against COVID-19-associated ED/UC encounters, 35% (95% CI, 30%-40%) against COVID-19-associated hospitalization, and 41% (95% CI, 28%-51%) against COVID-19-associated critical illness 7 to 299 days after vaccination. Among immunocompetent adults 65 years and older (122 663 ED/UC encounters and 63 958 hospitalizations), estimated VE was 26% (95% CI, 22%-30%) against COVID-19-associated ED/UC encounters, 35% (95% CI, 29%-40%) against COVID-19-associated hospitalization, and 41% (95% CI, 28%-52%) against COVID-19-associated critical illness 7 to 299 days after vaccination. Among 32 629 hospitalizations in immunocompromised adults 18 years and older, estimated VE against COVID-19-associated hospitalization was 24% (95% CI, 13%-34%). VE estimates waned with more time since vaccination. In this test-negative case-control study, 2024-2025 COVID-19 vaccination was associated with reduced likelihood of medically attended COVID-19-associated outcomes among immunocompetent and immunocompromised adults, highlighting the importance of adults receiving recommended COVID-19 vaccinations.
Source: PubMed (PMID: 42295789)View Original on PubMed