Mapping the landscape of vitamin D in chronic and idiopathic pain: A bibliometric analysis (2000-2023).

Abstract

Recent studies have revealed that the anti-inflammatory properties of vitamin D may play a role in pain regulation. To systematically map the global research landscape on vitamin D and chronic or idiopathic pain from 2000 to 2023, this study aims to identify publication trends, influential countries, institutions, authors, and journals, as well as to characterize the evolution of research themes and emerging hotspots using bibliometric methods. Using the keywords "vitamin D," "pain," "idiopathic pain," and "fibromyalgia" as search terms, a systematic search was conducted in the Web of Science Core Collection to identify relevant literature published between January 2000 and December 2023. After screening according to predefined inclusion and exclusion criteria, a total of 1899 articles were included. Using VOSviewer and CiteSpace software, we analyzed bibliometric data, including publication volume, citation metrics, Hirsch index, and journal impact factors, and visually presented collaboration networks, co-citation patterns, and keyword analysis results. A total of 1899 records were included. The number of research papers on vitamin D and chronic and idiopathic pain has steadily increased, rising from 14 in 2000 to a peak of 184 in 2021. The United States leads research output with 500 papers (26.33% of the total), followed by Italy and the United Kingdom. Harvard University and the University of Sydney ranked as the top institutions, demonstrating robust international collaboration. Co-citation analysis revealed distinct thematic clusters. Keyword analysis indicated that inflammation, osteoporosis, and vitamin D receptor genetics were primary research directions, with recent trends focusing on inflammation and vitamin D supplementation. This bibliometric analysis indicates that academic interest in the relationship between vitamin D and chronic pain is steadily increasing year by year, with developed countries making particularly significant contributions to this field of research. However, further in-depth exploration is required to definitively establish the clinical value of vitamin D in pain management. Meanwhile, the findings also highlight the importance of international collaboration and suggest that vitamin D may hold greater potential in the treatment of chronic pain.