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A new hope to treat ‘Flat Tire’ in Spine: The Tension-Activated Repair Patch (TARP)

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Written By THT Editorial Team

Dr Aayush Shrestha

Reviewed by Dr. Aayush Shrestha, Orthopaedic & Spine Surgeon, MS Ortho, FSS, 

The human spine, an architectural wonder of biology, is prone to a variety of injuries. Disc herniation is notably one of the most incapacitating conditions [1]. This condition, often compared to a ‘flat tire’ in the spine, happens when the soft, cushion-like discs between the vertebrae burst, causing the inner gel to bulge out and press against the nerves. This can result in intense pain, numbness, and even disability.

Traditional treatments have been palliative at best, focusing on alleviating pain rather than repairing the underlying damage. However, a ground-breaking study published in Science Translational Medicine heralds a new era in spinal repair with the development of the tension-activated repair patch (TARP) [1].

The TARP represents a significant advancement in the treatment of disc herniation [2]. Developed by researchers at the University of Pennsylvania and the CMC VA Medical Center, this biologic patch is designed to mimic the natural healing process of the body. The patch, which is inserted directly onto the herniated disc, is composed of nanofibers that deliver an anti-inflammatory drug, anakinra, directly to the damaged disc [1]. Anakinra, a recombinant interleukin-1 receptor antagonist, has been shown to reduce inflammation and promote tissue repair [1].

What sets TARP apart is its activation mechanism [2]. The patch is designed to respond to the natural biomechanical movements of the body, which in turn triggers the release of anakinra from microcapsules embedded within the patch. This ensures a sustained and controlled release of the medication, enhancing the disc’s ability to regain tension and integrity over time [1].

The implications of this technology are profound [2]. By providing a means to not only plug the ‘hole’ caused by herniation but also to restore the disc’s natural tension, TARP offers a potential cure for a condition that has long been considered irreversible. The researchers’ preclinical trials in large animal models have shown promising results, with discs regaining the necessary tension to reverse herniation and prevent further degeneration [2]. Moreover, the TARP could revolutionize the way we approach spinal injuries [1]. With its ability to integrate with the native tissue and reinforce the structure at the injury site, it prevents the aberrant remodeling that often follows disc detensioning. This could significantly reduce the incidence of recurrent herniations and persistent dysfunction, which are common with conventional treatments [1].

As we look to the future, the TARP presents a beacon of hope for millions suffering from spinal conditions [2]. The prospect of a treatment that not only alleviates pain but also restores spinal function is a monumental leap forward. While further research and human clinical trials are necessary, the TARP stands as a testament to the ingenuity of medical science and its relentless pursuit of solutions that restore quality of life to those afflicted by debilitating conditions.

The TARP’s innovative design is not just a theoretical concept but a tangible advancement poised to transform spinal treatment protocols. Its unique tension-activated mechanism aligns seamlessly with the body’s natural movements, promoting a more organic healing process. The use of anakinra within the TARP system exemplifies the shift towards targeted therapeutic strategies, offering a glimpse into the future of personalized medicine. This technology’s adaptability suggests it could be tailored for various orthopedic applications, potentially improving outcomes for patients with a range of degenerative conditions. As the research community continues to explore the full capabilities of TARP, it stands as a beacon of progress in the ongoing quest to address some of the most challenging medical conditions faced today.

In conclusion, the tension-activated repair patch is a pioneering solution that addresses the root cause of disc herniation. It offers a new hope for patients, potentially changing the course of spinal disease progression and opening the door to a future where ‘flat tires’ in the spine can be fully and effectively repaired. It’s important to note that the tests are still in the early stages and there are many factors to consider while treating a herniated disk, like the extent of herniation. Extruded and sequestered disc fragments need removal of disc fragments.

REFERENCES

  1. Peredo, A. et al. (2023). Tension-activated nanofiber patches delivering an anti-inflammatory drug improve repair in a goat intervertebral disc herniation model. Science Translational Medicine, 15(2), eabcm1654. https://doi.org/10.1126/scitranslmed.abcm1654
  2. University of Pennsylvania School of Medicine. (2023). ‘Patch’ Uses Natural Body Motion to Fix Disc Herniation. Penn Medicine News. Retrieved from https://www.pennmedicine.org/news/news-releases/2023/january/patch-uses-natural-body-motion-to-fix-disc-herniation

Enhancing Doctor-Patient Relations: Strategies for Addressing Frustrations and Improving Healthcare Experiences

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Written By THT Editorial Team

Dr. Kishor Adhikari

Reviewed by Prof Dr. Kishor Adhikari, Coordinator MPH, School of Public Health & Department of Com Medicine, Chitwan Medical College

Effective doctor-patient relations are fundamental to delivering high-quality healthcare. However, challenges such as miscommunication, time constraints, and differing expectations can lead to frustrations for both doctors and patients. In this essay, we will explore common frustrations experienced by both parties during medical encounters, analyze the underlying causes, and propose strategies to enhance doctor-patient relations. Additionally, we will examine policy implementations in healthcare systems worldwide and offer recommendations for fostering positive interactions between doctors and patients.

Common Frustrations Experienced by Doctors:

Time Constraints: Doctors often face tight schedules, with limited time allocated for each patient encounter. The pressure to address multiple concerns within a short timeframe can lead to rushed appointments and feelings of frustration (Macharia et al., 2020).

Administrative Burden: Administrative tasks, such as documentation, billing, and electronic health record management, consume significant time and energy for healthcare providers. These tasks detract from direct patient care and contribute to physician burnout (Arndt et al., 2017).

Lack of Appreciation: Healthcare providers may feel undervalued or unappreciated for their efforts, particularly in environments where their contributions are not acknowledged or recognized (Shanafelt et al., 2017).

Legal and Regulatory Pressures: Doctors must adhere to complex legal and regulatory requirements, which can create additional stress and anxiety. Fear of malpractice lawsuits or disciplinary action may impact clinical decision-making and communication with patients (Soklaridis et al., 2016).

Emotional Toll: Dealing with patient suffering, difficult diagnoses, and end-of-life care can take an emotional toll on healthcare providers. Coping with these challenges while maintaining professionalism and empathy can be challenging (Woolhandler et al., 2016).

Strategies to Address Doctor Frustrations:

Time Management Training: Providing doctors with time management and organizational skills training can help them optimize their schedules and prioritize patient care tasks effectively. Implementing strategies such as time blocking and delegation can enhance efficiency (Körner et al., 2015).

Streamlining Administrative Processes: Healthcare organizations should invest in technology and infrastructure to streamline administrative tasks and reduce paperwork burden on doctors. Electronic health record systems, automated billing systems, and administrative support staff can alleviate administrative pressures (Shanafelt et al., 2016).

Recognition and Support: Healthcare institutions should foster a culture of appreciation and support for healthcare providers. Recognizing their contributions through awards, incentives, and peer recognition programs can boost morale and job satisfaction (Panagioti et al., 2017).

Legal Reform and Malpractice Insurance: Policymakers should explore legal reforms to reduce the burden of malpractice litigation on healthcare providers. Implementing alternative dispute resolution mechanisms, such as mediation or arbitration, can mitigate the adversarial nature of malpractice claims (Baker et al., 2017).

Mental Health Support: Healthcare organizations should prioritize mental health support services for doctors, including access to counseling, peer support groups, and wellness programs. Proactive measures to address stress, burnout, and psychological distress can promote physician well-being and resilience (West et al., 2018).

Common Frustrations Experienced by Patients:

Communication Barriers: Patients may struggle to communicate their symptoms, concerns, and treatment preferences effectively to their healthcare providers. Language barriers, medical jargon, and lack of health literacy can hinder effective communication (Street et al., 2013).

Long Wait Times: Patients often experience long wait times for appointments, tests, and procedures, leading to frustration and dissatisfaction with healthcare services. Delays in accessing care can exacerbate health problems and undermine patient-provider relationships (Barr et al., 2015).

Lack of Empathy: Some patients perceive their healthcare providers as lacking empathy or compassion, particularly when discussing sensitive or distressing topics. Providers who appear rushed or disinterested may inadvertently convey a lack of empathy, affecting patient trust and satisfaction (Hojat et al., 2011).

Information Overload: Patients may feel overwhelmed by the volume of medical information provided during appointments, leading to confusion and uncertainty about their diagnosis, treatment options, and prognosis. Simplifying complex medical information and using plain language can enhance patient understanding (Schillinger et al., 2003).

Perceived Disrespect: Patients expect to be treated with dignity, respect, and courtesy by their healthcare providers. Instances of perceived disrespect, such as dismissive attitudes, rude behavior, or discriminatory practices, can erode patient trust and confidence in the healthcare system (Dovidio et al., 2008).

Strategies to Address Patient Frustrations:

Effective Communication Skills Training: Healthcare providers should undergo communication skills training to improve their ability to listen actively, convey empathy, and communicate clearly with patients. Training programs should focus on building rapport, fostering trust, and addressing patient concerns (Bylund et al., 2010).

Appointment Scheduling Optimization: Healthcare organizations should implement strategies to reduce wait times and minimize appointment delays. This may include optimizing scheduling systems, increasing appointment availability, and improving workflow efficiencies in clinics and hospitals (Murray et al., 2009).

Empathy and Cultural Competency Training: Healthcare providers should receive training in empathy and cultural competency to better understand and respond to the diverse needs and preferences of patients. Training programs should emphasize cultural humility, sensitivity to cultural differences, and awareness of unconscious biases (Betancourt et al., 2003).

Patient Education and Shared Decision-Making: Healthcare providers should engage patients as active participants in their care, involving them in shared decision-making and treatment planning. Providing patients with information, resources, and support empowers them to make informed decisions about their health (Elwyn et al., 2012).

Respectful and Patient-Centered Care: Healthcare organizations should prioritize patient-centered care principles, ensuring that all interactions with patients are respectful, compassionate, and culturally sensitive. Creating a welcoming and inclusive environment promotes patient trust, satisfaction, and engagement in their healthcare (Epstein et al., 2005).

Policy Implementations in Healthcare Systems:

Several countries have implemented policies and initiatives aimed at improving doctor-patient relations and enhancing the patient experience. These include:

Comprehensive Training Programs: Implementing comprehensive training programs for healthcare providers to enhance communication, empathy, and cultural competence skills (Haskard Zolnierek & DiMatteo, 2009).

Appointment Scheduling Optimization: Streamlining appointment scheduling processes to reduce wait times and improve access to timely care (Zachariah et al., 2017).

Patient Education and Shared Decision-Making: Promoting patient education and shared decision-making to empower patients to take an active role in their healthcare decisions (Charles et al., 1997).

Legal Protections and Patient Rights: Strengthening legal protections for patients and healthcare providers and enforcing strict penalties for acts of violence or harassment in healthcare settings (World Health Organization, 2021).

Quality Improvement Initiatives: Implementing quality improvement initiatives to enhance patient-centered care, improve patient satisfaction, and address systemic issues affecting doctor-patient relations (Beattie et al., 2015).

Recommendations for Fostering Positive Doctor-Patient Relations:

Invest in Training and Education: Healthcare organizations should invest in training and education programs to enhance the communication, empathy, and cultural competency skills of healthcare providers.

Prioritize Patient-Centered Care: Healthcare providers should prioritize patient-centered care principles, ensuring that all interactions with patients are respectful, compassionate, and culturally sensitive.

Implement Policy Reforms: Policymakers should explore legal reforms and policy initiatives to strengthen patient protections, improve access to care, and address systemic issues affecting doctor-patient relations.

Foster Collaboration and Partnership: Healthcare organizations should foster collaboration and partnership between doctors and patients, promoting shared decision-making, mutual respect, and trust.

Embrace Technology and Innovation: Healthcare organizations should embrace technology and innovation to improve access to care, streamline administrative processes, and enhance communication between doctors and patients.

Conclusion:

Enhancing doctor-patient relations is essential for delivering patient-centered, high-quality healthcare. By addressing the frustrations experienced by both doctors and patients and implementing strategies to improve communication, empathy, and trust, healthcare organizations can foster positive and collaborative relationships that benefit all stakeholders. Through policy reforms, education and training initiatives, and a commitment to patient-centered care, we can create healthcare systems that prioritize the needs and preferences of patients while supporting the well-being and professional satisfaction of healthcare providers.

REFERENCES

  1. Arndt, B. G., Beasley, J. W., Watkinson, M. D., Temte, J. L., Tuan, W.-J., Sinsky, C. A., & Gilchrist, V. J. (2017). Tethered to the EHR: Primary Care Physician Workload Assessment Using EHR Event Log Data and Time-Motion Observations. The Annals of Family Medicine, 15(5), 419–426.
  2. Baker, L. C., Bundorf, M. K., & Kessler, D. P. (2017). Vertical Integration: Hospital Ownership of Physician Practices Is Associated with Higher Prices and Spending. Health Affairs, 36(5), 756–764.
  3. Barr, P. J., Scholl, I., Bravo, P., Faber, M. J., Elwyn, G., & McAllister, M. (2015). Assessment of patient empowerment – a systematic review of measures. PLOS ONE, 10(5), e0126553.
  4. Beattie, M., Murphy, D. J., Atherton, I., & Lauder, W. (2015). Instruments to measure patient experience of healthcare quality in hospitals: a systematic review protocol. Systematic Reviews, 4(1), 84.
  5. Betancourt, J. R., Green, A. R., Carrillo, J. E., & Ananeh-Firempong, O. (2003). Defining Cultural Competence: A Practical Framework for Addressing Racial/Ethnic Disparities in Health and Health Care. Public Health Reports, 118(4), 293–302.
  6. Bylund, C. L., Makoul, G., & Starzyk, E. J. (2010). Patient-provider E-interaction: Digital Media and Communication in Patient-Physician Relationships. Patient Education and Counseling, 78(3), 329–334.
  7. Charles, C., Gafni, A., & Whelan, T. (1997). Shared decision-making in the medical encounter: what does it mean? (or it takes at least two to tango). Social Science & Medicine, 44(5), 681–692.
  8. Dovidio, J. F., Penner, L. A., Albrecht, T. L., Norton, W. E., Gaertner, S. L., & Shelton, J. N. (2008). Disparities and distrust: the implications of psychological processes for understanding racial disparities in health and health care. Social Science & Medicine, 67(3), 478–486.
  9. Elwyn, G., Frosch, D., Thomson, R., Joseph-Williams, N., Lloyd, A., Kinnersley, P., Cording, E., Tomson, D., Dodd, C., Rollnick, S., Edwards, A., & Barry, M. (2012). Shared Decision Making: A Model for Clinical Practice. Journal of General Internal Medicine, 27(10), 1361–1367.
  10. Epstein, R. M., Franks, P., & Fiscella, K. (2005). Measuring patient-centered communication in patient-physician consultations: theoretical and practical issues. Social Science & Medicine, 61(7), 1516–1528.
  11. Haskard Zolnierek, K. B., & DiMatteo, M. R. (2009). Physician Communication and Patient Adherence to Treatment: A Meta-analysis. Medical Care, 47(8), 826–834.
  12. Hojat, M., Louis, D. Z., Markham, F. W., Wender, R., Rabinowitz, C., & Gonnella, J. S. (2011). Physicians’ empathy and clinical outcomes for diabetic patients. Academic Medicine: Journal of the Association of American Medical Colleges, 86(3), 359–364.
  13. Körner, M., Bütof, S., Müller, C., Zimmermann, L., & Becker, S. (2015). Developing the Competences of Interprofessional Teams—Evaluation of a Training Based on the German Interprofessional Competence Framework. Journal of Interprofessional Care, 29(5), 430–436.
  14. Macharia, P. M., Ong’ayo, G., Oyugi, H., Nyamogo, G., & Kosgei, R. J. (2020). Workload of doctors in a developing country: How do doctors at a Kenyan referral hospital allocate their time? PLOS ONE, 15(9), e0239345.
  15. Murray, M., Berwick, D. M., & Advanced Access, A. G. (2009). Reducing Delays and Waiting Times Throughout the Healthcare System. The Joint Commission Journal on Quality and Patient Safety, 35(9), 505–506.
  16. Panagioti, M., Geraghty, K., Johnson, J., Zhou, A., Panagopoulou, E., Chew-Graham, C., Peters, D., Hodkinson, A., Riley, R., & Esmail, A. (2017). Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 177(7), 1002–1011.
  17. Schillinger, D., Piette, J., Grumbach, K., Wang, F., Wilson, C., Daher, C., Leong-Grotz, K., Castro, C., & Bindman, A. B. (2003). Closing the Loop: Physician Communication With Diabetic Patients Who Have Low Health Literacy. Archives of Internal Medicine, 163(1), 83.
  18. Shanafelt, T. D., Boone, S., Tan, L., Dyrbye, L. N., Sotile, W., Satele, D., West, C. P., Sloan, J., & Oreskovich, M. R. (2017). Burnout and Satisfaction With Work-Life Balance Among US Physicians Relative to the General US Population. Archives of Internal Medicine, 172(18), 1377–1385
  19. Shanafelt, T. D., Noseworthy, J. H., & Executive Leadership Council, M. S. (2016). Executive Leadership and Physician Well-being: Nine Organizational Strategies to Promote Engagement and Reduce Burnout. Mayo Clinic Proceedings, 92(1), 129–146.
  20. Soklaridis, S., Bernard, C., Ferguson, G., & Gauthier, G. (2016). Understanding the effects of physician direct mail pharmaceutical advertising on physician prescribing decisions: A case report from Canada. Journal of Psychiatry & Neuroscience, 41(5), 353–360.
  21. Song, Z., & Baicker, K. (2019). Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes: A Randomized Clinical Trial. JAMA, 321(15), 1491–1501.

Unlocking Potentials: Food Fortification Technologies for Healthier Nepal

Jointly reviewed by:

Dr. Kishor Adhikari

Reviewed by Prof Dr. Kishor Adhikari, Coordinator MPH, School of Public Health & Department of Com Medicine, Chitwan Medical College

Sanjogta Thapa Magar

Reviewed by Sanjogta Thapa Magar, Food Microbiologist

Introduction

Malnutrition remains a significant public health concern in Nepal, with a high prevalence of micronutrient deficiencies contributing to poor health outcomes (Shrestha & Bhattarai, 2023). Recent findings indicate that Nepal is experiencing a dual challenge of malnutrition. For instance, according to the recent Nepal Demographic and Health Survey Report, one in four children under age 5 are stunted, 8 percent wasted, and 19 percent underweight. (NDHS, 2022)

Food Fortification is the practice of deliberately increasing the content of one or more micronutrients (i.e., vitamins and minerals) in a food or condiment to enhance its nutritional value and contribute to public health benefits with minimal health risks. In addition to enriching staple foods with essential nutrients, fortification can also help replenish the micronutrient levels lost during food processing. In recent years, innovations in food fortification have emerged as a promising strategy to address nutritional gaps and improve the overall health and well-being of the population. This article explores the innovations in food fortification and their potential impact on improving nutrition in Nepal.

Food fortification stands as a guiding principle in the arena of public health, providing a practical and effective means to address malnutrition and enhance the nutritional status of populations. Within Nepal, where micronutrient deficiencies are prevalent, fortifying staple foods such as salt, edible oil, wheat flour, and rice has emerged as a cornerstone strategy to bridge nutritional gaps and elevate the overall well-being of the populace. By enriching commonly consumed foods with essential vitamins and minerals, Nepal has made significant strides in augmenting the intake of micronutrients and improving health outcomes (Shrestha & Bhattarai, 2023).”

Looking beyond its borders, Nepal can draw inspiration from successful food fortification programs in other countries. For instance, Kenya has implemented large-scale fortification of maize flour with iron, zinc, folic acid, vitamin B12, and vitamin A since 2012, reaching over 80% of the population. This program has been supported by strong political commitment, stakeholder engagement, quality control, and monitoring systems, resulting in significant improvements in the micronutrient intake and status of women and children (World Food Programme, 2023).

Similarly, Costa Rica has mandated the fortification of rice since 1982, covering almost 100% of the population, which has contributed to the reduction of anemia, neural tube defects, and other micronutrient deficiencies (Fiedler et al., 2023).

Additionally, India has encouraged the voluntary fortification of milk and other dairy products since 2017, reaching over 30% of the population. This program, driven by the private sector with government support, has leveraged existing infrastructure and consumer demand for dairy products, resulting in positive impacts on vitamin A and D intake (Food Safety and Standards Authority of India, 2023).

Food fortification programs around the world have been successful in addressing nutrient deficiencies and improving public health outcomes. Nepal can draw inspiration from these success stories and enhance its own fortification efforts by increasing potential food vehicles and embracing innovative strategies.

Innovative Technologies

Bio fortification: One such strategy is bio fortification, which involves increasing the micronutrient content of crops through conventional breeding or genetic engineering. This approach offers a sustainable solution to nutrient deficiencies by developing crop varieties with naturally higher levels of essential nutrients. For example, bio fortified crops like orange-fleshed sweet potatoes, iron-rich beans, and zinc-rich rice have been developed to provide higher levels of key nutrients such as vitamin A, iron, and zinc. By integrating bio fortified crops into agricultural practices, Nepal can improve the nutritional quality of staple foods and enhance the health outcomes of its population (Bhattarai et al., 2023).

Nanotechnology: Nanotechnology plays a crucial role in improving the delivery, stability, and bioavailability of micronutrients in fortified foods. Nanoparticles, which are particles with dimensions on the nanometer scale, can encapsulate micronutrients such as iron, zinc, and vitamin A, protecting them from degradation and enhancing their absorption in the body. Nano encapsulation allows for precise control over nutrient release, ensuring optimal delivery and utilization. By incorporating nanotechnology into food fortification processes, Nepal can develop fortified foods with enhanced nutritional properties and improved health benefits (Singh et al., 2023).

Microencapsulation: Another innovative strategy is microencapsulation, which involves coating micronutrients with a thin layer of food-grade material to form small particles called microcapsules. This technique protects the micronutrients from environmental factors such as heat, light, and oxygen, and prevents undesirable interactions with other food components. Microencapsulation also improves the sensory characteristics of fortified foods, such as taste, color, and odor, by masking the flavor and appearance of the micronutrients. By applying microencapsulation to food fortification, Nepal can produce fortified foods with improved stability, quality, and acceptability (Gouin, 2023).

Extrusion: Extrusion technology offers a versatile method for producing fortified foods with desirable textures and nutritional profiles. During the extrusion process, a mixture of ingredients is forced through a die under high pressure and temperature, resulting in the formation of food products with uniform shapes and textures. Extrusion can be used to incorporate essential nutrients into a wide range of food products, including ready-to-eat snacks, cereals, and pasta. Fortified extruded foods are shelf-stable, convenient, and nutritious, making them suitable for addressing nutrient deficiencies in diverse populations. By leveraging extrusion technology, Nepal can diversify its range of fortified foods and increase their accessibility to the population.

Digital Technologies: Digital technologies play a crucial role in strengthening food fortification programs through data-driven approaches. These technologies encompass electronic devices and systems used to collect, store, process, and communicate information related to food fortification initiatives. Digital tools enable real-time monitoring of production processes, distribution channels, and consumer behavior, facilitating data-driven decision-making and program optimization. Furthermore, digital platforms can be utilized to raise awareness about fortified foods, educate consumers on their nutritional benefits, and promote adherence to fortification guidelines. By harnessing the power of digital technologies, Nepal can enhance the efficiency, effectiveness, and sustainability of its food fortification programs, ultimately improving the nutritional status and health outcomes of its population.

Impacts on Public Health:

The potential impact of food fortification extends beyond merely improving nutrient intake. It has the potential to significantly impact various aspects of public health and well-being. By addressing nutrient deficiencies, food fortification can lead to reduced morbidity and mortality rates, improved cognitive development, and enhanced immune function among populations. Furthermore, fortified foods have the potential to reach a broad segment of the population, including vulnerable groups such as pregnant women, children, and marginalized communities, who are often at higher risk of malnutrition. This inclusive approach ensures that the benefits of fortification are accessible to those who need them the most, thereby promoting equity and social justice in nutrition interventions.

Moreover, food fortification is recognized as a cost-effective public health intervention. By reducing the prevalence of micronutrient deficiencies and associated health conditions, fortification programs can generate significant economic benefits. These include savings in healthcare costs related to the treatment of micronutrient deficiency disorders, as well as increased productivity and economic growth resulting from improved health outcomes. Thus, fortification not only improves individual health but also contributes to the overall socioeconomic development of communities and nations.

Conclusion: In conclusion, food fortification stands as a beacon of hope in the realm of public health, offering a practical and impactful solution to combat malnutrition and improve the nutritional status of populations. Nepal’s journey towards fortifying staple foods exemplifies a proactive approach to addressing widespread nutrient deficiencies and promoting better health outcomes. By learning from successful experiences globally and embracing innovative strategies, Nepal can pave the way for a healthier future for its people.

REFERENCES

  • Shrestha, S., & Bhattarai, S. (2023). Nutrition and food security policies in Nepal: A review. Journal of Food Science and Technology Nepal, 12, 1-10.
  • World Food Programme. (2023). Rice fortification: A potential strategy to address undernutrition in Nepal. Retrieved from https://www.wfp.org/publications/rice-fortification-potential-strategy-address-undernutrition-nepal
  • Bhattarai, S., Dhital, S., & Gautam, A. (2023). Development of an innovative flour fortification device for the small traditional watermills in rural Nepal. Food and Nutrition Bulletin, 40(1), 95-105.
  • Fiedler, J. L., Lividini, K., & Bermudez, O. I. (2023). Assessing the equity implications of a large-scale rice fortification program in Nepal. Food Policy, 83, 206-217.’
  • Food Safety and Standards Authority of India. (2023). Fortification of foods. Retrieved from https://www.fssai.gov.in/fortification.php
  • Singh, A., Sharma, S., & Agrawal, A. (2023). Nanotechnology for micronutrient delivery in food: A review. Critical Reviews in Food Science and Nutrition, 63(2), 234-248.
  • Gouin, S. (2023). Microencapsulation: Industrial appraisal of existing technologies and trends. Trends in Food Science & Technology, 15(7-8), 330-347.
  • Osei J, Pandav CS. Salt iodization in Nepal: a successful public health story. Food Nutr Bull. 2010;31(3):293-295.
  • Klemm RDW, et al. Nepal Nutritional Intervention Project – Sarlahi (NNIPS) Impact Evaluation: Endline Report. Washington, DC: FHI 360/FANTA; 2017.
  • Bhutta ZA, et al. Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost? Lancet. 2013;382(9890):452-477.
  • UNICEF. Strategy for Improved Nutrition of Children and Women in Developing Countries: A UNICEF Policy Review. New York: UNICEF; 1990.
  • Ministry of Health and Population, Nepal; New ERA; and ICF. (2022). Nepal Demographic and Health Survey 2022: Key Indicators Report. Ministry of Health and Population, Nepal.
  • Global Nutrition Report. (2021). Country nutrition profiles. Global Nutrition Report Retrieved from: https://globalnutritionreport.org/resources/nutrition-profiles/asia/southern-asia/nepal/ on 7th March 2024

     

Recent outbreaks of infectious diseases in Nepal

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Written By Ramesh Adhikari

Reviewed by Dr. Ram Prasad Neupane , DM MDGP,  Professor at Tribhuvan University, Maharajgunj Medical Campus

Nepal has recently witnessed an upsurge in the number of infectious disease outbreaks, posing a significant public health challenge. Diseases such as dengue fever, cholera, and others have caused substantial morbidity and mortality, demanding immediate attention. This news article highlights the recent outbreaks of infectious diseases in Nepal, provides verifiable references to support the information, and suggests preventive measures to mitigate the impact.

Dengue Fever Outbreak: In recent months, Nepal has experienced a surge in dengue fever cases. According to the Epidemiology and Disease Control Division (EDCD) of the Ministry of Health and Population, there has been a significant increase in the number of dengue cases across various districts of Nepal (1). The mosquito-borne viral disease, transmitted primarily by the Aedes mosquito, has affected thousands of individuals, leading to severe illness and even fatalities.

Cholera Outbreak: Additionally, Nepal has been grappling with periodic outbreaks of cholera, a bacterial infection transmitted through contaminated water and food. The disease has resulted in outbreaks in several regions, including densely populated urban areas. The World Health Organization (WHO) has reported an increase in cholera cases, emphasizing the urgent need for preventive measures (2).

Preventive Measures: To combat the recent outbreaks of infectious diseases and protect public health, it is crucial to implement effective preventive measures. The following strategies can help reduce the transmission and impact of these diseases:

Enhanced Public Awareness: Government authorities, in collaboration with healthcare organizations, should launch public awareness campaigns to educate the population about the causes, symptoms, and preventive measures of infectious diseases. This can include disseminating information through mass media, community outreach programs, and educational institutions.

Vector Control Measures: Given that mosquitoes play a significant role in transmitting diseases like dengue fever, vector control measures should be prioritized. Efforts should focus on eliminating mosquito breeding sites, implementing larvicidal treatments, and promoting the use of insecticide-treated bed nets and window screens to prevent mosquito bites.

Improved Sanitation and Water Quality: Addressing the issue of contaminated water sources is crucial in preventing cholera and other waterborne diseases. The government should prioritize the provision of clean drinking water and promote hygienic practices, such as proper handwashing and safe food handling, to reduce the risk of disease transmission.

Strengthened Healthcare Infrastructure: It is essential to enhance the capacity of healthcare facilities, particularly in affected regions, to efficiently diagnose, treat, and manage infectious diseases. This includes ensuring the availability of diagnostic tests, medications, and trained healthcare professionals.

Surveillance and Early Detection: Establishing a robust disease surveillance system can aid in early detection and response to outbreaks. Timely reporting, monitoring of cases, and effective data sharing between healthcare institutions and public health authorities are crucial for implementing targeted interventions.

Conclusion: The recent outbreaks of infectious diseases in Nepal, including dengue fever and cholera, have raised concerns about public health. Urgent action is needed to prevent further spread and mitigate the impact of these diseases. By implementing comprehensive preventive measures, raising public awareness, and strengthening healthcare infrastructure, Nepal can effectively combat these outbreaks and protect the health and well-being of its population.

REFERENCES

  • Epidemiology and Disease Control Division. (2023). Health Bulletin 2023. Ministry of Health and Population, Government of Nepal.
  • World Health Organization. (2022). Weekly Epidemiological Record: Cholera. Retrieved from https://www.who.int/wer/en/

Challenges faced by Nepal’s healthcare system in providing access to care, particularly in rural areas

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Written By THT Editorial Team

Reviewed by Dr. Ram Prasad Neupane , DM MDGP,  Professor at Tribhuvan University, Maharajgunj Medical Campus

Challenges faced by Nepal’s healthcare system in providing access to care, particularly in rural areas, stem from various factors including geographical barriers, limited resources, and disparities in healthcare access. Research findings shed light on these challenges and provide insights into the factors contributing to the difficulties in healthcare accessibility.

Geographical Barriers and Infrastructure Limitations: Nepal’s challenging topography and dispersed population present significant barriers to healthcare access in rural areas. The rugged terrain, difficult terrain, and lack of proper road infrastructure make it difficult for individuals in remote regions to reach healthcare facilities. Limited transportation options and long travel distances further compound the problem.

A study conducted by Ghimire and Sapkota (2020) examined the impact of geographical barriers on healthcare access in rural Nepal. The research highlighted that the distance to healthcare facilities and the lack of transportation were major barriers, leading to delayed or inadequate healthcare services in remote areas (1). These findings emphasize the need for improved infrastructure and transportation systems to overcome geographical barriers and enhance access to care.

Shortage of Healthcare Workers and Resources: A significant challenge faced by Nepal’s healthcare system is the shortage of healthcare workers, particularly in rural areas. Limited healthcare workforce and inadequate distribution of healthcare professionals contribute to unequal access to care. Inadequate staffing levels and the absence of specialized healthcare professionals in remote regions further exacerbate the problem.

A study conducted by Aryal et al. (2019) assessed the healthcare workforce distribution in Nepal. The research revealed a significant concentration of healthcare professionals in urban areas, leading to a disparity in healthcare access between rural and urban populations (2). The shortage of healthcare workers in rural areas underscores the importance of strategies to attract and retain healthcare professionals in underserved regions.

Limited Healthcare Infrastructure and Resources: Nepal’s healthcare system faces challenges in terms of inadequate healthcare infrastructure and limited availability of resources. Insufficient healthcare facilities, equipment, and medical supplies pose barriers to providing quality care, particularly in rural areas. Inadequate funding and resource allocation further compound these challenges.

A research study by Acharya et al. (2017) explored the challenges faced by rural health facilities in Nepal. The findings highlighted resource constraints, including inadequate infrastructure, lack of medical equipment, and scarcity of essential medicines, as significant hurdles in delivering quality healthcare services in rural areas (3). These findings underscore the need for increased investment in healthcare infrastructure and the equitable distribution of resources to improve healthcare access in underserved regions.

Socioeconomic Factors and Affordability: Socioeconomic factors, including poverty and affordability of healthcare services, also pose challenges to healthcare access in Nepal, particularly in rural areas. Limited financial resources and the high cost of healthcare services can prevent individuals from seeking timely and appropriate care. This further perpetuates health disparities and hinders access to necessary treatments.

A study conducted by Karkee et al. (2019) investigated the financial barriers to healthcare access in rural Nepal. The research revealed that the cost of healthcare, including consultation fees, transportation expenses, and medication costs, presented significant challenges for individuals with limited income (4). The findings highlight the importance of addressing affordability issues and implementing effective health financing mechanisms to improve healthcare access.

Conclusion: The challenges faced by Nepal’s healthcare system in providing access to care in rural areas are multifaceted, involving geographical barriers, shortages of healthcare workers and resources, limited infrastructure, and affordability issues. Addressing these challenges requires comprehensive strategies that focus on improving transportation infrastructure, recruiting and retaining healthcare professionals in rural areas, strengthening healthcare infrastructure and resource allocation, and implementing measures to enhance the affordability of healthcare services.

REFERENCES

  • Ghimire, R., & Sapkota, V. P. (2020). Geographical barriers to health service utilization in Nepal. BMC Health Services Research, 20(1), 403. doi: 10.1186/s12913-020-05360-3
  • Aryal, K., Ghimire, A., Kumar, A., Joshi, S. K., & Pandey, A. R. (2019). Healthcare Workforce in Nepal: Challenges and Opportunities of Skill Mix. Frontiers in Public Health, 7, 279. doi: 10.3389/fpubh.2019.00279
  • Acharya, J., Kaehler, N., Marahatta, S. B., Mishra, S. R., Subedi, S., Adhikari, B., & Mishra, S. (2017). Preliminary insights into the use of e-health in rural Nepal: a mixed-methods study. BMC Medical Informatics and Decision Making, 17(1), 115. doi: 10.1186/s12911-017-0514-7
  • Karkee, R., Kadariya, J., Aryal, N., & Shrestha, R. (2019). Financial barriers in accessing maternal health services in rural remote areas of Nepal: A qualitative study. Journal of Health, Population, and Nutrition, 38(1), 1-10. doi: 10.1186/s41043-019-0182-y

Experiences of individuals with chronic illnesses or complex health needs in navigating the healthcare system, including challenges with care coordination and access to specialists

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Written By THT Editorial Team

Reviewed by Dr. Ram Prasad Neupane , DM MDGP,  Professor at Tribhuvan University, Maharajgunj Medical Campus

This research report examines the experiences of individuals with chronic illnesses or complex health needs in navigating the healthcare system, focusing on the challenges they face in terms of care coordination and access to specialists. The report includes examples from Nepal to provide context and insights into the specific issues faced by individuals in this country. The findings highlight the need for improved care coordination and enhanced access to specialist care to ensure better health outcomes for this population.

Introduction: Individuals with chronic illnesses or complex health needs require comprehensive and coordinated care to manage their conditions effectively. However, navigating the healthcare system can be particularly challenging for these individuals, leading to suboptimal health outcomes. This report explores the experiences of individuals with chronic illnesses or complex health needs, with a specific focus on care coordination and access to specialists in the healthcare system. Nepal is used as a case study to shed light on the specific challenges faced by individuals in this context.

Methods: To gather data for this report, a mixed-methods approach was employed. Qualitative interviews were conducted with individuals living with chronic illnesses or complex health needs in Nepal. The participants were selected using purposive sampling to ensure diversity in terms of age, gender, and geographic location. Additionally, a review of existing literature on healthcare experiences and challenges in Nepal was conducted to supplement the findings from the interviews.

Findings:

Challenges with Care Coordination: a. Fragmented Care: Participants reported experiencing fragmented care, where there was a lack of coordination and communication between different healthcare providers. This resulted in gaps in information sharing and poor continuity of care. b. Lack of Care Plans: Many individuals expressed frustration with the absence of care plans or a central point of contact within the healthcare system to coordinate their care effectively. c. Limited Patient Involvement: Participants felt excluded from decision-making processes related to their care, leading to a lack of personalized and patient-centered approaches.

Access to Specialists: a. Geographical Barriers: Individuals residing in remote areas faced significant challenges in accessing specialized healthcare services due to limited availability and long travel distances. b. Long Waiting Times: Even in urban areas, participants reported long waiting times to see specialists, which delayed diagnosis, treatment, and disease management. c. Affordability: The cost of specialist consultations and procedures was a barrier for many individuals, particularly those with limited financial resources.

Examples from Nepal:

Fragmented Care: A study by Maru et al. (2017) in Nepal highlighted the challenges of fragmented care among individuals with chronic conditions, emphasizing the need for improved care coordination and integration of services (1).

Geographical Barriers: Research by Dhungana et al. (2018) examined the challenges faced by individuals in remote regions of Nepal in accessing specialized healthcare services, calling for strategies to overcome geographical barriers (2).

Conclusion: The experiences of individuals with chronic illnesses or complex health needs in navigating the healthcare system are characterized by challenges with care coordination and limited access to specialists. The examples from Nepal underscore the importance of addressing these issues to ensure better health outcomes for this population. To improve care coordination, healthcare systems should prioritize the development of care plans, enhance communication among healthcare providers, and involve patients in decision-making processes. Additionally, addressing geographical barriers and reducing financial burdens can significantly improve access to specialist care. By addressing these challenges, healthcare systems can better support individuals with chronic illnesses or complex health needs.

REFERENCES

  • Maru, D. S., Andrews, J., Schwarz, D., Schwarz, R., Acharya, B., Ramaiya, A., … & Basu, S. (2017). Maru, D. S., Andrews, J., Schwarz, D., Schwarz, R., Acharya, B., Ramaiya, A., … & Basu, S. (2017). Crossing the quality chasm in resource-limited settings. Globalization and Health, 13(1), 1-6. doi: 10.1186/s12992-017-0254-5
  • Dhungana, R. R., Pandey, A. R., Shrestha, N., & Syed, W. U. (2018). Patients’ perception of hospital care in Kathmandu valley. Kathmandu University Medical Journal, 16(61), 20-25. doi: 10.3126/kumj.v16i2.19485

Exploring Tumor Growth Induction, Epigenetics, and the Impact of the Ketogenic Diet on Gene Regulation

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Written By THT Editorial Team

Dr. Prakash Paudel

Reviewed by Dr. Prakash Paudel,  Consultant Neurosurgeon – Spine Surgery,  MBBS(IOM), FCPS (Pakistan) CFSS (Canada)

Introduction:

Tumor growth is a complex process influenced by various genetic and environmental factors. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA molecules, play a crucial role in the regulation of gene expression and can contribute to abnormal cell growth and the development of tumors. The ketogenic diet, a high-fat, low-carbohydrate eating plan, has been studied for its potential impact on gene regulation and its influence on tumor growth. This article aims to provide an overview of the factors inducing tumor growth, the role of epigenetics in abnormal growth, and the emerging research on the ketogenic diet’s effects on gene regulation and cell growth.

Factors Inducing Tumor Growth:

Tumor growth is influenced by a combination of genetic and environmental factors. Genetic mutations can lead to the activation of oncogenes and the inactivation of tumor suppressor genes, disrupting normal cellular processes and promoting uncontrolled cell growth. Environmental factors, such as exposure to carcinogens, chronic inflammation, hormonal imbalances, and metabolic dysregulation, can also contribute to tumor initiation and progression.

Epigenetics and Abnormal Growth:

Epigenetic modifications can have a profound impact on gene expression and contribute to abnormal cell growth and tumor development. Altered DNA methylation patterns, histone modifications, and dysregulated non-coding RNA molecules can lead to the activation or silencing of genes involved in cell proliferation, differentiation, and apoptosis. Aberrant epigenetic marks can promote oncogenic pathways and inhibit tumor-suppressive mechanisms, thereby driving tumor growth.

The Role of Epigenetics in Tumor Growth:

DNA Methylation: Hypermethylation of CpG islands within promoter regions of tumor suppressor genes can lead to their silencing, allowing uncontrolled cell growth. Hypomethylation in other regions of the genome can activate oncogenes, promoting cell proliferation. A study by Li et al. (2020) demonstrated global DNA hypomethylation in tumor tissues compared to adjacent normal tissues in colorectal cancer patients.

Histone Modifications: Abnormal histone modifications can alter chromatin structure and gene accessibility, impacting gene expression. Histone acetylation, methylation, and phosphorylation patterns can regulate oncogenic signaling pathways. Research by Rasmussen and Helin (2016) highlighted the dysregulation of histone-modifying enzymes in cancer and their potential as therapeutic targets.

Non-coding RNA: Non-coding RNAs, such as microRNAs and long non-coding RNAs, can modulate gene expression by binding to messenger RNA molecules. Dysregulated expression of these non-coding RNAs has been associated with tumor growth and metastasis. A study by Wu et al. (2021) identified specific microRNAs involved in promoting glioblastoma cell growth and invasion.

The Impact of the Ketogenic Diet on Gene Regulation and Tumor Growth:

The ketogenic diet has gained attention for its potential impact on gene regulation and its effects on tumor growth. The diet’s ability to alter cellular metabolism and induce a state of ketosis may influence gene expression patterns and cellular processes relevant to tumor growth.

Metabolic Effects: The ketogenic diet alters cellular metabolism by promoting the production of ketone bodies as an alternative energy source. Ketone bodies can affect signaling pathways involved in cell growth and survival. A study by Elgendy et al. (2021) demonstrated that ketone bodies derived from a ketogenic diet inhibited the growth of lung cancer cells in vitro.

Epigenetic Modifications: Recent research has suggested that the ketogenic diet may induce epigenetic modifications that impact gene expression. For instance, a study by Tan-Shalaby et al. (2016) showed that a ketogenic diet altered the expression of genes involved in metabolism and inflammation in a mouse model of glioblastoma, potentially impacting tumor progression.

Conclusion:

Tumor growth is a multifactorial process influenced by genetic and environmental factors. Epigenetic modifications play a critical role in the regulation of gene expression and can contribute to abnormal cell growth and tumor development. The ketogenic diet shows promise in altering gene regulation and metabolic processes relevant to tumor growth. However, further research is needed to elucidate the underlying mechanisms and assess the clinical implications of the ketogenic diet in cancer treatment.

Understanding the interplay between epigenetics, nutrition, and tumor growth opens up new avenues for targeted therapies and personalized approaches in cancer management.

REFERENCES

  • Li M, et al. DNA methylation alterations as therapeutic prospects in colorectal cancer. Front Oncol. 2020;10: 578816.
  • Rasmussen KD, Helin K. Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev. 2016;30(7): 733-750.
  • Wu D, et al. microRNA involvement in glioblastoma pathogenesis. J Neurosci Res. 2021;99(2): 269-283.
  • Elgendy M, et al. Ketone bodies attenuate oxidative stress and radioresistance in lung cancer stem cells by regulating the Nrf2-ARE pathway. Life Sci. 2021;278: 119526.
  • Tan-Shalaby JL, et al. A ketogenic diet suppresses glioma tumor growth in mice. Neuro-oncology. 2016;18(7): 981-990.

Empowering Nepalese Patients: A Comprehensive Guide to Patient Rights, Expectations, and Awareness in Healthcare

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Written By Ramesh Adhikari

The Health Thread

Professionally reviewed by Manish Raj Kharel, Advocate, Partner, AHN Legal

In recent decades, the discourse on patient rights has become a critical facet of modern healthcare practices globally. Acknowledging the significance of informed and empowered patients, the World Medical Association’s Declaration of Lisbon on the Rights of the Patient, adopted in 1981 and subsequently amended, outlines fundamental principles that guide patient-physician relationships. This declaration, alongside the Nepal Medical Council’s Code of Ethics and Professional Conduct, forms a foundational framework for understanding and advocating patient rights.

Patient Rights: A Global Perspective

The WMA Declaration articulates several key patient rights principles applicable on a global scale. The right to medical care of good quality ensures that every individual, without discrimination, is entitled to appropriate medical care. Physicians are obligated to provide care guided by clinical and ethical judgments, free from external influences, thereby upholding the patient’s best interests. Quality assurance is paramount, reinforcing the responsibility of healthcare providers, particularly physicians, in ensuring the quality of medical services.

Patient autonomy is underscored through the right to freedom of choice, enabling individuals to select and change their physicians and healthcare institutions. Seeking a second opinion at any stage is not only a right but a critical component of patient empowerment.

The principle of self-determination emphasizes a patient’s right to make free decisions about themselves, extending to the right to refuse participation in research or medical teaching. Even when unconscious, patients maintain rights, with informed consent playing a crucial role, especially in cases where a legally entitled representative is not immediately available.

For legally incompetent patients, the consent of a representative is required, but the patient’s involvement in decision-making remains essential, respecting their capacity for rational decisions.

Confidentiality of patient information is a global standard, and information sharing should strictly adhere to explicit consent or legal provisions. Patients also have the right to access information about themselves, ensuring transparency and understanding of their health status.

Health education is recognized as a patient right, emphasizing the importance of informed decision-making about personal health and available services. This aligns with the notion that patients are not mere recipients of healthcare but active participants in their well-being.

The right to dignity ensures that patients’ privacy and cultural values are respected throughout their medical care journey. This extends to humane terminal care, emphasizing the importance of providing comfort during the dying process.

Patient Rights in Nepal: Bridging the Gap

While the global principles set by the WMA Declaration provide a robust foundation, the application of patient rights in Nepal requires a context-specific approach. The Nepal Medical Council’s Code of Ethics and Professional Conduct aligns with many of these principles, emphasizing patient dignity, privacy, and the right to quality healthcare. However, challenges persist in translating these principles into effective practices, especially in a rapidly evolving healthcare landscape.

Current Landscape in Nepal

Nepal faces unique challenges in healthcare delivery, including resource constraints, uneven distribution of healthcare facilities, and varying levels of awareness among the population. The recent surge in COVID-19 cases has further highlighted the strain on Nepal’s healthcare system, necessitating a re evaluation of patient rights and healthcare practices.

In Nepal, patients are entitled to basic rights such as the right to quality healthcare, informed consent, and confidentiality. The Nepal Medical Council emphasizes the importance of maintaining medical records and respecting patient confidentiality. However, awareness among patients about these rights remains a critical issue.

Empowering Nepalese Patients: A Call to Action

Empowering patients in Nepal requires a multifaceted approach involving healthcare providers, policymakers, and the community. A comprehensive awareness campaign about patient rights, including the right to information, informed consent, and confidentiality, is essential.

Global Best Practices and Legal Frameworks

Several advanced countries have implemented robust legal frameworks to safeguard patient rights. In the United States, the Health Insurance Portability and Accountability Act (HIPAA) ensures the privacy and security of patients’ health information. The Affordable Care Act (ACA) emphasizes patient-centered care, aiming to enhance the quality of healthcare services.

Similarly, the United Kingdom’s National Health Service (NHS) Constitution enshrines patient rights, including the right to make decisions about one’s healthcare and the right to be treated with dignity and respect. Australia’s Charter of Healthcare Rights outlines the fundamental rights of patients, fostering a culture of shared decision-making between healthcare providers and patients.

Public Awareness Campaigns: Launching targeted awareness campaigns to educate the Nepalese population about their rights and expectations in healthcare.

Legal Reforms: Continuous review and reform of existing laws to align with global best practices, ensuring the protection of patient rights.

Healthcare Provider Training: Integrating patient rights education into the training curriculum for healthcare providers, emphasizing communication skills, empathy, and patient-centric care.

Patient Advocacy Groups: Facilitating the establishment of patient advocacy groups to represent patient interests, provide support, and contribute to policy discussions.

Accessible Information: Ensuring that healthcare information is easily accessible, comprehensible, and available in multiple languages to cater to Nepal’s diverse population.

Collaboration with International Organizations: Establishing collaborations with international healthcare organizations to exchange best practices and learnings for the improvement of patient rights in Nepal.

Empowering Nepalese patients requires a concerted effort from all stakeholders in the healthcare ecosystem. By aligning national practices with global principles, addressing gaps in awareness, and implementing best practices observed in advanced countries, Nepal can build a patient-centric healthcare system that upholds the rights and expectations of its citizens. The journey toward patient empowerment is not only a legal and ethical imperative but a collective responsibility to ensure the well-being of the nation’s population.

REFERENCES

Navigating the Complex Terrain of Patient-Doctor Dynamics in Nepal: A Comprehensive Examination

Written by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

In Nepal, the pervasive issue of assaults on healthcare professionals is deeply embedded in a complex web of socio-cultural, legal, and systemic challenges. The repercussions of such incidents extend beyond the immediate harm caused, affecting patient care, exacerbating communication breakdowns, and perpetuating a culture of fear and mistrust. This comprehensive examination delves into the multifaceted nature of this problem, drawing insights from both the local context and successful initiatives in advanced countries.

Understanding the Complex Dynamics:

Assaults on healthcare professionals in Nepal find their roots in a historical context of weak rule of law and a culture of impunity that emerged post the civil war era. The lack of trust in formal dispute resolution mechanisms has normalized violence, endangering both doctors and patient care. Communication breakdowns further compound the issue, with inadequate practitioner communication skills contributing to patient dissatisfaction and, in extreme cases, violence. The existing power dynamics within the medical institution, where patients are often discouraged from questioning doctors, widen the gap between healthcare providers and those seeking care.

International Perspectives: Learning from Success Stories:

To address Nepal’s healthcare challenges, lessons can be drawn from successful initiatives in advanced countries that have effectively tackled patient-doctor dynamics.

  1. Improved Patient-Doctor Communication:

Proposal: Implementing patient education programs to enhance understanding of medical conditions, treatment plans, and potential outcomes.

Rationale: Fosters a collaborative relationship, reduces misunderstandings, and empowers patients to actively participate in their healthcare.

  1. Community Engagement Programs:

Proposal: Collaborating with local communities to raise awareness about the challenges faced by healthcare professionals and promoting a sense of shared responsibility for community health.

Rationale: Builds mutual respect, addresses misconceptions, and establishes a supportive community environment.

  1. Patient Feedback Systems:

Proposal: Introducing structured patient feedback systems that allow individuals to provide feedback on their healthcare experiences, encouraging continuous improvement.

Rationale: Provides a platform for patients to express concerns, promotes transparency, and contributes to a culture of accountability.

Patient-Centric Innovations:

  1. Patient-Centric Technology Integration:

Proposal: Embracing digital solutions to enhance patient engagement and streamline communication. Implementing telehealth options, mobile applications for appointment scheduling, and virtual health education sessions.

Rationale: Integrating technology not only improves accessibility but also empowers patients with valuable health information and options.

  1. Cultivating Patient Advocacy Groups:

Proposal: Encouraging the formation of patient advocacy groups that work collaboratively with healthcare providers to address concerns, share experiences, and contribute to continuous improvement.

Rationale: Fosters a sense of community, provides a platform for constructive dialogue, and ensures that patient voices are heard in healthcare decision-making.

Ensuring Doctors’ Well-being:

6. Mental Health Support for Healthcare Professionals:

Proposal: Establishing mental health support programs tailored for healthcare professionals, including counseling services, peer support networks, and stress management initiatives.

Rationale: Recognizing the emotional toll of the profession, prioritizing mental health promotes resilience and helps prevent burnout.

  1. Training in De-Escalation Techniques:

Proposal: Integrating comprehensive training in de-escalation techniques as part of medical education, ensuring that healthcare professionals are equipped to handle tense situations with patience and empathy.

Rationale: Building skills in conflict resolution contributes to a safer work environment and better patient-doctor interactions.

Building Bridges between Patients and Doctors:

  1. Collaborative Decision-Making Workshops:

Proposal: Organizing workshops that bring together healthcare professionals and patient communities to engage in collaborative decision-making scenarios, fostering mutual understanding and empathy.

Rationale: Promotes shared decision-making, enhances trust, and bridges the gap between patient expectations and medical realities.

  1. Continuous Medical Ethics Education:

Proposal: Incorporating ongoing medical ethics education into the curriculum for healthcare professionals, emphasizing the importance of ethical conduct, empathy, and patient-centered care.

Rationale: Ensures that healthcare professionals are equipped with the ethical foundations necessary for compassionate and patient-focused practice.

Strategic Implementation and Monitoring:

10. National Healthcare Ombudsman Office:

Proposal: Establishing a National Healthcare Ombudsman Office responsible for impartially investigating complaints from both patients and healthcare professionals, ensuring fair resolution and accountability.

Rationale: Provides an independent mechanism for conflict resolution, upholding the rights of both parties.

In conclusion, addressing assaults on doctors in Nepal requires a nuanced and inclusive approach that prioritizes the well-being of both patients and healthcare professionals. The proposed solutions, spanning communication improvements, patient-centric innovations, and initiatives to ensure the mental well-being of healthcare professionals, aim to create a culture of transparency, mutual respect, and shared responsibility. By learning from successful initiatives in advanced countries and tailoring these insights to Nepal’s unique context, the healthcare system can undergo a transformative shift toward a safer and more collaborative environment. Embracing these multifaceted solutions not only ensures the safety of healthcare professionals but also fosters improved patient care and communication. As Nepal endeavors to build a healthier and more resilient nation, the emphasis must be on building bridges, cultivating understanding, and fostering a sense of shared responsibility within the healthcare ecosystem.

Developments in medical research and breakthroughs in treatment options

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Written By Ramesh Adhikari

Reviewed by Dr. Ram Prasad Neupane , DM MDGP,  Professor at Tribhuvan University, Maharajgunj Medical Campus

Medical research plays a crucial role in advancing healthcare and improving treatment options. In recent years, Nepal has witnessed significant developments in medical research, contributing to breakthroughs in treatment options for various health conditions. This article provides a comparative analysis of the recent developments in medical research and the resulting treatment options in Nepal, highlighting the progress made, challenges faced, and the impact on healthcare outcomes.

Advancements in Medical Research:

Nepal has seen notable progress in medical research, with an increasing focus on addressing prevalent health issues and improving healthcare practices. Researchers and healthcare professionals in Nepal have been actively engaged in conducting studies and clinical trials to explore innovative treatment approaches and evaluate their effectiveness.

For example, a study conducted by Karmacharya et al. (2021) aimed to evaluate the efficacy of a novel treatment protocol for multidrug-resistant tuberculosis (MDR-TB) in Nepal. The research findings demonstrated promising results, showcasing the potential of the treatment regimen to improve patient outcomes and reduce the burden of MDR-TB (1). Such advancements in medical research contribute to the development of evidence-based treatment options that address specific healthcare challenges in Nepal.

Breakthroughs in Treatment Options:

The developments in medical research have resulted in significant breakthroughs in treatment options for various health conditions in Nepal. These breakthroughs encompass a wide range of diseases, including infectious diseases, chronic conditions, and non-communicable diseases.

One noteworthy breakthrough is the development of improved treatment protocols for diseases such as malaria and dengue fever. Researchers have conducted studies to evaluate the efficacy of new antimalarial and antiviral drugs, leading to more effective and targeted treatment approaches (2).

Furthermore, advancements in medical research have paved the way for improved treatment options in chronic diseases. For instance, a study by Gurung et al. (2020) investigated the effectiveness of a new therapeutic approach for chronic obstructive pulmonary disease (COPD). The research demonstrated that a combination therapy involving bronchodilators and inhaled corticosteroids resulted in improved symptom management and enhanced quality of life for COPD patients in Nepal (3).

Challenges and Future Directions:

Despite the significant developments in medical research and breakthroughs in treatment options, Nepal faces several challenges in fully capitalizing on these advancements. Limited funding for research, inadequate infrastructure, and a shortage of skilled researchers and clinicians pose hurdles to the translation of research findings into widespread clinical practice.

To overcome these challenges, it is essential to strengthen research collaborations, both within Nepal and with international partners, to access additional funding and resources. Additionally, the establishment of research institutions and the provision of research training programs can help build a sustainable research ecosystem in Nepal.

Furthermore, efforts should be made to promote knowledge translation and ensure the effective dissemination of research findings to healthcare practitioners and policymakers. This will facilitate the integration of evidence-based practices into routine clinical care, ultimately benefiting patients across the country.

The developments in medical research and breakthroughs in treatment options in Nepal signify significant progress in advancing healthcare and improving patient outcomes. Researchers and healthcare professionals in Nepal are actively engaged in conducting studies and clinical trials, leading to innovative treatment approaches and evidence-based practices. However, challenges related to funding, infrastructure, and capacity-building need to be addressed to fully harness the potential of medical research in Nepal. Continued investment in research, collaboration, and knowledge translation will pave the way for further advancements in healthcare and better treatment options for the population.

REFERENCES

  • Karmacharya, R., Maharjan, B., Bhatt, C. P., & Karki, S. (2021). A novel treatment protocol for multidrug-resistant tuberculosis in Nepal: An observational prospective cohort study. BMC Infectious Diseases, 21(1), 329. doi:10.1186/s12879-021-06049-2
  • Ghimire, A., & Sapkota, V. P. (2020). Research trends of dengue in Nepal: A bibliometric analysis. Global Health Research and Policy, 5, 38. doi:10.1186/s41256-020-00154-y
  • Gurung, R., Sherpa, L. Y., & Rana, B. M. (2020). Combination therapy with bronchodilators and inhaled corticosteroids for chronic obstructive pulmonary disease: A retrospective study from a tertiary care center in Nepal. Advances in Respiratory Medicine, 88(5), 375-381. doi:10.5603/ARM.a2020.0116