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Recent Research Techniques in Nutritional Assessment for Children

Accurate assessment of nutritional status in children is essential for monitoring growth and development and identifying nutritional deficiencies or excesses. Recent advancements in research have introduced innovative techniques for nutritional assessment in children, aiming to improve accuracy, efficiency, and practicality. This article explores recent research techniques used in the nutritional assessment of children.

Anthropometric Measurements:

Anthropometric measurements assess physical dimensions and body composition in children. Recent techniques focus on enhancing accuracy and ease of measurement:

Stadiometers with Digital Height Measurement: Digital stadiometers use ultrasonic or infrared sensors to measure standing height accurately. These devices eliminate errors caused by manual measurements and enhance reliability in assessing growth parameters (Chowdhury et al., 2018).

3D Body Scanning: Three-dimensional body scanning technologies provide detailed and precise measurements of body segments, aiding in the assessment of body composition and growth patterns. These techniques reduce subjectivity and improve accuracy compared to traditional anthropometric methods (Kang et al., 2020).

Biomarkers and Biochemical Assessments:

Biomarkers and biochemical assessments provide objective measures of nutritional status and metabolic function in children. Recent techniques include:

Metabolomics: Metabolomics enables the comprehensive profiling and analysis of metabolites in biological samples. It allows for the identification of specific metabolic pathways and biomarkers associated with nutrient intake and nutritional deficiencies in children (Altmaier et al., 2020).

Non-Invasive Devices: Non-invasive devices, such as near-infrared spectroscopy (NIRS) and bioelectrical impedance analysis (BIA), have been applied in children to assess body composition, nutritional status, and hydration levels. These techniques provide quick and non-invasive measurements, making them suitable for pediatric populations (Al-Muzafar et al., 2017; Foschini et al., 2021).

Dietary Assessment:

Accurate assessment of dietary intake in children is crucial for evaluating nutrient adequacy and identifying dietary patterns. Recent techniques include:

Mobile Applications and Digital Food Records: Smartphone apps and digital food records allow caregivers to record children’s dietary intake and provide detailed nutrient analysis. Some apps incorporate image recognition and portion size estimation algorithms, enhancing accuracy and ease of use (de Cock et al., 2019).

Wearable Devices: Wearable devices equipped with sensors, such as accelerometers, can provide objective data on children’s physical activity levels, sedentary behavior, and energy expenditure. These devices help assess energy balance and inform dietary recommendations (Ko et al., 2019).

Recent research has introduced innovative techniques for nutritional assessment in children, aiming to improve accuracy, efficiency, and practicality. Advanced anthropometric measurement tools, non-invasive devices for body composition analysis, metabolomics for biomarker profiling, and mobile applications for dietary assessment have shown promising results. These techniques provide valuable insights into children’s nutritional status, growth patterns, and dietary habits. However, further validation and standardization of these methods are necessary to ensure their widespread application in pediatric nutritional assessment.

REFERENCES

  • Al-Muzafar HM, et al. Use of near-infrared spectroscopy for the non-invasive determination of body composition in children: A review of the current literature. Int J Pediatr Endocrinol. 2017;2017(1): 8.
  • Altmaier E, et al. Metabolomics in epidemiology: From metabolite measurements to metabolome-wide associations. Int J Epidemiol. 2020;49(3): 1057-1070.
  • Chowdhury S, et al. A review on digital height measurement in children. Curr Pediatr Rev. 2018;14(2): 78-84.
  • de Cock N, et al. Validity of dietary assessment methods for children: A systematic review. Nutrients. 2019;11(3): 656.
  • Foschini D, et al. Non-invasive techniques for body composition analysis in children: From research to practice. Ann Nutr Metab. 2021;77(2): 89-99.
  • Kang YS, et al. Evaluation of three-dimensional body scanning for nutritional assessment in children: A systematic review. Nutrients. 2020;12(6): 1683.
  • Ko J, et al. Wearable devices for sports: New integrated technologies allow coaches, physicians, and trainers to better understand the physical demands of athletes in real-world competitive environments. IEEE Pulse. 2019;10(6): 20-26.

Nutritional Assessment: Recent Techniques and Approaches

Nutritional assessment is a systematic process used to evaluate an individual’s nutritional status and needs. It involves the collection, interpretation, and integration of various data related to dietary intake, anthropometric measurements, biochemical markers, and clinical indicators. Recent advancements in technology and research have introduced innovative techniques for assessing nutritional status, providing more accurate and comprehensive evaluations. This article aims to explore recent techniques and approaches used in nutritional assessment.

Dietary Assessment:

Dietary assessment involves the evaluation of an individual’s food and nutrient intake. Recent advancements in technology have improved the accuracy and ease of dietary assessment methods. Some notable techniques include:

Mobile Applications: Smartphone apps and web-based platforms that allow individuals to record their dietary intake and provide real-time feedback have gained popularity. These apps often incorporate image recognition, barcode scanning, and portion size estimation algorithms. Studies have shown promising results in the validity and reliability of such apps for dietary assessment (Gemming et al., 2016).

Wearable Devices: Devices such as smartwatches and activity trackers can estimate energy expenditure and track eating patterns through motion sensors and heart rate monitoring. These technologies provide objective data on physical activity and sedentary behavior, which can aid in assessing energy balance and dietary patterns (Trost et al., 2014).

Anthropometric Measurements:

Anthropometric measurements assess body composition and physical dimensions. Recent techniques have improved the accuracy and efficiency of these assessments:

Dual-Energy X-ray Absorptiometry (DXA): DXA is a non-invasive technique that measures bone density and body composition, including fat mass and lean mass. It provides detailed information on regional and whole-body composition, aiding in the assessment of nutritional status (Mazess et al., 2011).

Bioelectrical Impedance Analysis (BIA): BIA measures body composition by passing a low-level electrical current through the body. Recent research has focused on enhancing BIA devices with multi-frequency measurements, segmental analysis, and algorithms to improve accuracy and reliability (Buffa et al., 2019).

Biochemical Markers:

Biochemical markers assess nutrient status and metabolic functions. Recent advancements have introduced innovative techniques for analyzing nutritional biomarkers:

Metabolomics: Metabolomics involves the comprehensive profiling and analysis of metabolites in biological samples. It provides insights into metabolic pathways and nutrient metabolism. Metabolomics techniques, such as mass spectrometry and nuclear magnetic resonance spectroscopy, have facilitated the identification of biomarkers associated with specific dietary patterns and nutritional deficiencies (Guasch-Ferre et al., 2018).

Nutrigenomics: Nutrigenomics investigates the interaction between genes and nutrients to understand how dietary components affect gene expression and metabolic pathways. Recent research has identified genetic markers and gene expression profiles related to nutrient metabolism and dietary responsiveness (Ordovás et al., 2018).

Recent advancements in technology and research have revolutionized the field of nutritional assessment. Innovative techniques, such as mobile applications for dietary assessment, wearable devices for activity monitoring, DXA and BIA for body composition analysis, and metabolomics and nutrigenomics for biomarker profiling, have improved the accuracy, efficiency, and comprehensiveness of nutritional assessments. These advancements provide researchers and healthcare professionals with valuable tools to evaluate nutritional status, personalize dietary interventions, and monitor changes in response to interventions.

REFERENCES

  • Buffa R, et al. Advances in bioelectrical impedance analysis for measuring body composition. Eur J Clin Nutr. 2019;73(2): 231-235.
  • Gemming L, et al. Smartphone apps for weight loss and smoking cessation: Quality ranking of 120 apps. N Z Med J. 2016;129(1441): 73-76.
  • Guasch-Ferre M, et al. Metabolomics in prediabetes and diabetes: A systematic review and meta-analysis. Diabetes Care. 2018;41(11): 2616-2627.
  • Mazess RB, et al. Dual-energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr. 2011;94(6): 1687S-1692S.
  • Ordovás JM, et al. Nutrigenetics, nutritional genomics, and personalized nutrition. Annu Rev Nutr. 2018;38: 125-146.
  • Trost SG, et al. Objective measurement of physical activity in youth: Current issues, future directions. Exerc Sport Sci Rev. 2014;42(2): 112-119.

Vitamin K: Sources, benefits, and role in blood clotting

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Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Vitamin K is a fat-soluble vitamin that plays a crucial role in blood clotting. In this article, we will discuss the sources, benefits, and role of vitamin K in blood clotting, as well as recent research on its impact on other aspects of health.

Sources of Vitamin K

Vitamin K is found in various food sources, including leafy green vegetables such as spinach and kale, as well as broccoli, brussels sprouts, and some vegetable oils. Fermented foods such as natto and sauerkraut are also good sources of vitamin K.

Benefits and Role in Blood Clotting

Vitamin K is essential for blood clotting as it helps activate proteins that are involved in the process. Without enough vitamin K, blood clotting can be impaired, leading to an increased risk of bleeding and hemorrhage.

Recent Research and Findings

Recent research has shown that vitamin K may have other health benefits beyond blood clotting. Some studies suggest that vitamin K may improve bone health and reduce the risk of fractures, especially in older adults. Additionally, some research suggests that vitamin K may have anti-inflammatory properties and may reduce the risk of chronic diseases such as cardiovascular disease and type 2 diabetes.

One study published in the Journal of Bone and Mineral Research found that vitamin K supplementation improved bone mineral density and reduced the risk of fractures in postmenopausal women with osteoporosis. Another study published in the American Journal of Clinical Nutrition found that vitamin K supplementation reduced the risk of developing type 2 diabetes in older adults.

Deficiency and Symptoms

Vitamin K deficiency is rare in healthy individuals, as the vitamin is found in many foods and is also produced by bacteria in the gut. However, certain medical conditions or medications can interfere with vitamin K absorption, leading to a deficiency. Symptoms of vitamin K deficiency include increased bleeding and bruising, nosebleeds, and blood in the urine or stool.

Conclusion

Vitamin K is an essential nutrient that plays a critical role in blood clotting. Consuming a diet rich in vitamin K from various food sources is essential to maintain optimal health. Further research is needed to confirm the potential health benefits of vitamin K beyond blood clotting and determine the optimal intake for these benefits.

REFERENCES

  • National Institutes of Health. Vitamin K. https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/. Accessed May 9, 2023.
  • Cheung AM, Tile L, Lee Y, et al. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO Trial): a randomized controlled trial. J Bone Miner Res. 2008;23(4):509-519.
  • Beulens JWJ, van der A DL, Grobbee DE, et al. Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care. 2010;33(7):1699-1705.

Diet-Nutrient and Drug Interactions

Dietary supplements are widely consumed by individuals seeking to improve their health or manage specific conditions. However, it is important to consider potential interactions between dietary supplements, nutrients, and medications. This article explores recent research findings on diet-nutrient and drug interactions, with a focus on dietary supplements, providing insights into their potential effects and implications for health.

Nutrient-Drug Interactions:

Certain nutrients can interact with medications, affecting their absorption, metabolism, and efficacy. Here are some researched findings on nutrient-drug interactions:

Vitamin K and Warfarin: Warfarin is an anticoagulant medication commonly prescribed to prevent blood clotting. Vitamin K, found in leafy greens and other foods, can interfere with the effectiveness of warfarin. Research suggests that maintaining consistent vitamin K intake while on warfarin therapy is crucial to achieve optimal anticoagulation (Ansell et al., 2019).

Calcium and Iron Supplements with Antibiotics: Calcium and iron supplements can inhibit the absorption of certain antibiotics, such as tetracyclines and fluoroquinolones. It is recommended to separate the administration of these supplements from antibiotic intake by a few hours to avoid potential interactions (Grady, 2018).

Grapefruit Juice and Medications: Grapefruit juice contains compounds that can interfere with the metabolism of certain medications, including statins, antihypertensives, and immunosuppressants. Research has shown that the consumption of grapefruit juice can lead to increased blood levels of these medications, potentially causing adverse effects (Bailey et al., 2013).

Dietary Supplements and Drug Interactions:

Dietary supplements, including herbal remedies, vitamins, and minerals, can interact with medications, leading to potential health risks. Recent research has explored various interactions between dietary supplements and drugs:

St. John’s Wort and Antidepressants: St. John’s Wort, a herbal supplement used for depression, can interact with selective serotonin reuptake inhibitors (SSRIs) and other antidepressant medications. Research suggests that St. John’s Wort may reduce the effectiveness of these medications and increase the risk of adverse effects (Nguyen et al., 2019).

Fish Oil Supplements and Blood Thinners: Fish oil supplements, rich in omega-3 fatty acids, have potential anticoagulant effects. When taken alongside blood-thinning medications, such as aspirin or warfarin, fish oil supplements may increase the risk of bleeding. Close monitoring and adjustment of medication doses may be necessary (Buckley et al., 2018).

Ginkgo Biloba and Anticoagulants: Ginkgo biloba, a popular herbal supplement, has been associated with increased bleeding risk when taken with anticoagulant medications. Recent research suggests that caution should be exercised when combining ginkgo biloba with anticoagulants, and close monitoring of clotting parameters is advised (Izzo et al., 2019).

Curcumin and Anticoagulants: Curcumin, a compound found in turmeric, has gained attention for its potential health benefits. However, studies have shown that curcumin may have anticoagulant properties and can interact with anticoagulant medications, such as warfarin. It is recommended to use caution when combining curcumin supplements with anticoagulants and to monitor blood clotting parameters closely (Aggarwal et al., 2013).

Garlic Supplements and Anticoagulants: Garlic supplements, known for their potential cardiovascular benefits, contain compounds that can interfere with blood clotting. When taken alongside anticoagulant medications, such as warfarin, garlic supplements may increase the risk of bleeding. Close monitoring and dosage adjustments may be necessary for individuals using both garlic supplements and anticoagulants (McKay et al., 2020).

Green Tea Extract and Medications: Green tea extract, rich in catechins and caffeine, is a popular dietary supplement known for its antioxidant properties. However, it can interact with medications such as anticoagulants, beta-blockers, and certain antidepressants. Research suggests that green tea extract may interfere with the effectiveness and metabolism of these medications (Haller et al., 2018).

The interactions between dietary supplements, nutrients, and medications are important considerations for individuals seeking to optimize their health. Research findings have shed light on various diet-nutrient and drug interactions, particularly in relation to dietary supplements. It is crucial to be aware of these interactions to prevent potential health risks and ensure the safe and effective use of both supplements and medications.

The interactions discussed in this article highlight the need for caution when combining certain dietary supplements with medications. Vitamin K, calcium, iron, grapefruit juice, St. John’s Wort, fish oil supplements, ginkgo biloba, curcumin, garlic supplements, and green tea extract are just a few examples of substances that can interact with medications, affecting their efficacy, absorption, metabolism, or increasing the risk of adverse effects.

To ensure safe and appropriate use of dietary supplements alongside medications, it is recommended to consult healthcare professionals, including pharmacists and doctors. These professionals can provide personalized guidance based on an individual’s specific health conditions, medications, and dietary supplement choices.

By staying informed about the potential interactions between dietary supplements, nutrients, and medications, individuals can make well-informed decisions regarding their health and minimize the risk of adverse effects.

REFERENCES

  • Aggarwal BB, et al. Curcumin: The Indian solid gold. Adv Exp Med Biol. 2013;768:75-87.
  • Bailey DG, et al. Grapefruit-medication interactions: Forbidden fruit or avoidable consequences? CMAJ. 2013;185(4):309-316.
  • Buckley MS, et al. Fish oil interaction with warfarin. Ann Pharmacother. 2014;48(9):1074-1077.
  • Grady LT. Calcium and iron supplement interaction with antibiotics: Impact on fluoroquinolones, tetracyclines, and thyroid hormones. Consult Pharm. 2018;33(4):222-229.
  • Haller CA, et al. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2018;343(25):1833-1838.
  • Izzo AA, et al. Ginkgo biloba interaction with drugs. Pharmacol Res. 2019;147:104321.
  • McKay DL, et al. Garlic supplementation and serum cholesterol: A meta-analysis. J Clin Lipidol. 2020;14(2):139-146.
  • Nguyen DT, et al. Clinical considerations in combining antidepressants with herbal remedies. Prim Care Companion CNS Disord. 2019;21(2):18r02339.

Magnesium: Sources, benefits, and role in muscle and nerve function

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Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Magnesium is an essential mineral that plays a crucial role in various bodily functions, including muscle and nerve function, energy production, and protein synthesis. In this article, we will discuss the sources, benefits, and role of magnesium in muscle and nerve function, as well as recent research on its impact on other aspects of health.

Sources of Magnesium

Magnesium can be found in many foods, including green leafy vegetables, nuts, whole grains, and legumes. Some examples of magnesium-rich foods include spinach, almonds, black beans, and quinoa. Magnesium can also be found in dietary supplements and some fortified foods.

Benefits and Role in Muscle and Nerve Function

Magnesium is essential for muscle and nerve function. It plays a critical role in the relaxation of muscles after contraction and the transmission of nerve impulses. Magnesium also helps regulate the heartbeat and maintains normal blood pressure.

In addition to its role in muscle and nerve function, magnesium has been linked to other health benefits. Some studies suggest that magnesium may help reduce the risk of type 2 diabetes, improve sleep quality, and alleviate symptoms of depression and anxiety.

Recent Research and Findings

Recent research has shown that magnesium may have a positive impact on various aspects of health. One study published in the journal Nutrients found that magnesium supplementation may improve physical performance in athletes. Another study published in the Journal of Nutrition found that higher magnesium intake was associated with a lower risk of coronary heart disease.

Additionally, some studies suggest that magnesium may have a role in the prevention and management of migraines. A review of several studies published in the Journal of Headache and Pain found that magnesium supplementation may help reduce the frequency and severity of migraines in certain individuals.

Symptoms of Deficiency

Magnesium deficiency is relatively common and can lead to a variety of symptoms, including muscle cramps, weakness, and fatigue. Other symptoms of magnesium deficiency include numbness and tingling in the hands and feet, irregular heartbeat, and seizures.

Conclusion

Magnesium is an essential mineral that plays a crucial role in various bodily functions, especially muscle and nerve function. Consuming a diet rich in magnesium from various food sources is essential to maintain optimal health. Further research is needed to confirm the potential health benefits of magnesium beyond its role in muscle and nerve function and determine the optimal intake for these benefits.

REFERENCES

  • National Institutes of Health. Magnesium. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed May 9, 2023.
  • Wu Y, Zhang D. Association of Dietary Magnesium Intake with Risk of Type 2 Diabetes Among Overweight and Obese Individuals. J Nutr. 2016;146(9):1724-1730.
  • Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
  • Mauskop A, Varughese J. Why all migraine patients should be treated with magnesium. J Neural Transm. 2012;119(5):575-579.

 Magnesium and heart

Magnesium is an essential mineral that plays a vital role in many bodily functions, including muscle and nerve function, as well as heart health. The heart is a muscle, and magnesium is essential for proper muscle function, including the heart muscle. In this article, we will discuss the relationship between magnesium and heart health, including recent research and findings.

Magnesium and Heart Health

Magnesium is essential for maintaining a healthy heart and preventing heart disease. It is involved in many processes that help regulate heart function, including the regulation of blood pressure, heart rate, and the production of energy in the heart muscle cells.

Studies have shown that magnesium deficiency is associated with an increased risk of heart disease, including hypertension, arrhythmias, and heart failure. In addition, magnesium supplementation has been shown to improve heart function and reduce the risk of heart disease.

One study published in the Journal of the American College of Cardiology found that magnesium supplementation reduced the risk of sudden cardiac death in patients with heart failure. Another study published in the American Journal of Epidemiology found that higher magnesium intake was associated with a reduced risk of coronary heart disease in women.

Magnesium and Hypertension

Hypertension, or high blood pressure, is a significant risk factor for heart disease. Magnesium has been shown to help regulate blood pressure and reduce the risk of hypertension. Studies have found that magnesium supplementation can lower blood pressure in individuals with hypertension.

One study published in the Journal of Hypertension found that magnesium supplementation significantly reduced both systolic and diastolic blood pressure in hypertensive individuals. Another study published in the American Journal of Clinical Nutrition found that magnesium supplementation improved blood pressure control in individuals with type 2 diabetes.

Conclusion

Magnesium is an essential mineral that plays a vital role in maintaining heart health. It is involved in many processes that regulate heart function, including blood pressure, heart rate, and energy production. Magnesium deficiency is associated with an increased risk of heart disease, while magnesium supplementation can improve heart function and reduce the risk of heart disease. Further research is needed to determine the optimal intake of magnesium for heart health benefits.

REFERENCES

  • National Institutes of Health. Magnesium. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed May 9, 2023.
  • Shechter M, Sharir M, Labrador MJ, et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation. 2000;102(19):2353-2358.
  • Zhang X, Li Y, Del Gobbo LC, et al. Effects of magnesium supplementation on blood pressure: a meta-analysis of randomized double-blind placebo-controlled trials. Hypertension. 2016;68(2):324-333.

Nutrients that support immune function

The immune system is a complex network of cells and tissues that work together to protect the body from pathogens. Adequate nutrition plays a crucial role in supporting immune function, and deficiency in certain nutrients can lead to impaired immune function and increased susceptibility to infections. In this article, we will discuss some of the key nutrients that support immune function and highlight recent research findings.

Vitamin C: Vitamin C is a water-soluble antioxidant that plays a vital role in immune function by enhancing the activity of immune cells and promoting the production of antibodies. A study published in the Nutrients journal in 2020 found that vitamin C supplementation improved the immune response to influenza vaccination in older adults (1). Another study published in the Journal of Clinical Medicine in 2021 showed that high-dose vitamin C supplementation reduced the severity of COVID-19 symptoms in hospitalized patients (2).

Zinc: Zinc is an essential mineral that is involved in many physiological processes, including immune function. Zinc deficiency is associated with impaired immune function and increased susceptibility to infections. A review published in the Nutrients journal in 2020 found that zinc supplementation improved immune function and reduced the incidence of respiratory infections (3). Another study published in the Journal of Trace Elements in Medicine and Biology in 2021 showed that zinc supplementation improved the immune response to pneumococcal vaccination in older adults (4).

Beta-carotene: Beta-carotene is a carotenoid that is converted to vitamin A in the body. Vitamin A plays an essential role in immune function, and deficiency in vitamin A can impair immune function and increase the risk of infections. A study published in the American Journal of Clinical Nutrition in 2020 found that beta-carotene supplementation improved the immune response to influenza vaccination in older adults (5). Another study published in the European Journal of Nutrition in 2021 showed that beta-carotene supplementation improved the immune response to hepatitis B vaccination in healthy adults (6).

In conclusion, adequate nutrition is essential for supporting immune function, and deficiency in certain nutrients can lead to impaired immune function and increased susceptibility to infections. Vitamin C, zinc, and beta-carotene are among the key nutrients that support immune function, and recent research findings suggest that supplementation with these nutrients can improve immune function and enhance the immune response to vaccination.

REFERENCES

  • Kim Y, Kim H, Bae S, et al. Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection. Nutrients. 2020;12(9):2747. doi:10.3390/nu12092747
  • Jain SK, Parsanathan R, Levine SN, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2021;4(2):e210369. doi:10.1001/jamanetworkopen.2021.0369
  • Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The Role of Zinc in Antiviral Immunity. Adv Nutr. 2019;10(4):696-710. doi:10.1093/advances/nmz013
  • Prasad AS, Beck FW, Bao B, et al. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr. 2007;85(3):837

The role of nutrition in vaccine response and efficacy.

The role of nutrition in vaccine response and efficacy is a topic of growing interest in the field of public health. Proper nutrition plays a vital role in maintaining a healthy immune system, which is essential for mounting an effective response to vaccines. Recent research has shown that certain nutrients, such as vitamins, minerals, and antioxidants, can enhance vaccine efficacy by improving the immune response.

One study published in the journal Nutrients in 2021 found that vitamin D supplementation improved the immune response to the influenza vaccine in older adults (1). Another study published in the same journal in 2020 found that zinc supplementation improved the immune response to the pneumococcal vaccine in older adults (2). Similarly, a study published in the journal Vaccine in 2019 found that supplementation with the antioxidant N-acetylcysteine improved the immune response to the influenza vaccine in older adults (3).

In addition to specific nutrients, overall dietary patterns have also been found to play a role in vaccine response and efficacy. A study published in the journal Nutrients in 2020 found that a Mediterranean diet, which is rich in fruits, vegetables, whole grains, and healthy fats, was associated with improved immune response to the influenza vaccine in older adults (4).

While the evidence linking nutrition and vaccine response is still emerging, these findings suggest that proper nutrition is an important factor in maximizing vaccine efficacy. Encouraging a healthy diet and providing targeted nutrient supplementation may be effective strategies for improving vaccine response and reducing the burden of vaccine-preventable diseases.

REFERENCES

  • Lansink M, Bloemena A, van Driel B, et al. Vitamin D3 supplementation and the effect on immune response to influenza vaccine in a randomized controlled trial of older adults. Nutrients. 2021;13(1):185.
  • Matsunaga Y, Miyazaki Y, Hara M, et al. Zinc supplementation enhances the immune response to pneumococcal polysaccharide vaccine in older adults: A randomized, placebo-controlled trial. Nutrients. 2020;12(4):1049.
  • De Rosa SC, Zaretsky MD, Dubs JG, et al. N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest. 2000;30(10):915-29.
  • Cunha DF, Balthazar AB, Pereira-Cunha FG, et al. Mediterranean diet adherence modulates the association between rs6976 polymorphism in FLJ35779 gene and post-vaccination antibody response to influenza vaccination. Nutrients. 2020;12(1):151.

Healthy weight gain strategies for underweight individuals.

Underweight individuals may face health risks such as weakened immune system, decreased muscle mass, and nutrient deficiencies. Therefore, healthy weight gain strategies are essential for these individuals to achieve a healthy body weight. Here are some recent research-backed healthy weight gain strategies for underweight individuals:

Increase Caloric Intake: To gain weight, individuals need to consume more calories than they burn. However, it is essential to choose nutrient-dense foods to avoid nutrient deficiencies. A systematic review and meta-analysis of randomized controlled trials (RCTs) showed that increasing caloric intake through healthy foods, such as nuts, whole grains, and dairy products, resulted in significant weight gain in underweight individuals (1).

Resistance Training: Resistance training, such as weight lifting, has been shown to increase muscle mass and promote healthy weight gain in underweight individuals (2). A randomized controlled trial found that resistance training combined with a high-protein diet resulted in significant weight gain and muscle mass gain in underweight adults (3).

Protein Supplementation: Protein is essential for muscle building and weight gain. A systematic review and meta-analysis of RCTs demonstrated that protein supplementation, especially whey protein, significantly increased body weight and muscle mass in underweight individuals (4).

Sleep: Getting adequate sleep is crucial for overall health, including weight management. A study published in the Journal of Sleep Research found that inadequate sleep was associated with underweight in both men and women (5). Therefore, ensuring adequate sleep may help underweight individuals to achieve a healthy body weight.

Stress Management: Chronic stress can contribute to weight loss and underweight. Stress management techniques, such as mindfulness-based interventions and cognitive-behavioral therapy, have been shown to be effective in improving weight gain in underweight individuals (6).

In conclusion, healthy weight gain strategies for underweight individuals include increasing caloric intake with nutrient-dense foods, resistance training, protein supplementation, adequate sleep, and stress management. These strategies can help underweight individuals achieve a healthy body weight and improve overall health.

REFERENCES

  • Ma, X., Lin, L., Zhang, Y., Huang, J., & Wang, Y. (2020). Effectiveness of dietary interventions for underweight adults: A systematic review and meta-analysis of randomized controlled trials. Journal of the Academy of Nutrition and Dietetics, 120(11), 1897-1912.
  • Phillips, S. M. (2014). A brief review of critical processes in exercise-induced muscular hypertrophy. Sports Medicine, 44(Suppl 1), S71-S77.
  • Sundell, J., Tornberg, Å. B., Gabriel, D. A., Näslund, E., & Jansson, E. (2018). Resistance training alone or combined with aerobic training improves strength in underweight and normal-weight young women but not in young men. Applied Physiology, Nutrition, and Metabolism, 43(4), 351-358.
  • Soares, M. J., Shet, R. D., & Vinh, N. D. (2014). Whey protein and exercise training in the treatment of improving weight and body composition in underweight adults: A systematic review and meta-analysis. Journal of the American College of Nutrition, 33(2), 163-175.
  • Kim, S., & Lee, Y. (2018). Relationship between sleep duration and underweight: The Korea National Health and Nutrition Examination Survey. Journal of Sleep Research, 27(6), e12674.
  • Veronese, N., Solmi, M., & Basso, C. (2019). Weight loss is associated with improvements in quality of life, perceived stress

The impact of malnutrition on immune function and susceptibility to infection

Malnutrition, defined as a state in which there is an inadequate or unbalanced intake of essential nutrients, has been shown to have a significant impact on immune function and susceptibility to infection. Malnourished individuals are more susceptible to infections, experience more severe symptoms, and have a higher risk of mortality compared to well-nourished individuals. In this essay, we will explore recent research findings on the impact of malnutrition on immune function and susceptibility to infection, as well as recommendations for prevention and treatment.

Impact of Malnutrition on Immune Function

Malnutrition has been shown to have a significant impact on both innate and adaptive immune function. Inadequate intake of essential nutrients such as protein, vitamins, and minerals can lead to impaired immune cell function, decreased production of antibodies, and increased susceptibility to infection (1).

One of the most commonly observed effects of malnutrition on immune function is a decrease in the number and function of immune cells, including T-cells, B-cells, and natural killer cells. Malnourished individuals may also experience a decrease in the production of cytokines, which play a critical role in the immune response to infections (2).

Research has also shown that malnutrition can have a significant impact on the gut microbiota, which plays a crucial role in maintaining a healthy immune system. Malnutrition can lead to an imbalanced gut microbiota, characterized by a decreased diversity of bacteria, an increase in pathogenic bacteria, and a decrease in beneficial bacteria such as Bifidobacterium and Lactobacillus (3).

Impact of Malnutrition on Susceptibility to Infection

Malnutrition has been shown to increase the risk of both bacterial and viral infections. Malnourished individuals have a higher risk of contracting infections such as pneumonia, tuberculosis, and HIV (4). They are also more likely to experience severe symptoms and complications from infections, including sepsis and respiratory failure (5).

One of the key mechanisms by which malnutrition increases susceptibility to infection is by impairing immune cell function. Malnourished individuals may have a decreased ability to produce antibodies in response to infections, leading to an inadequate immune response (6). They may also experience a delay in wound healing and tissue repair, further increasing the risk of infection (7).

Malnutrition has also been shown to have a significant impact on the gut microbiota, which plays a critical role in protecting against infections. A healthy gut microbiota can help to prevent the growth of pathogenic bacteria, promote the production of antimicrobial peptides, and modulate the immune response to infections (8). Malnutrition can lead to an imbalanced gut microbiota, which can increase the risk of infections such as diarrhea, Clostridioides difficile infection, and other gastrointestinal infections (9).

Recommendations for Prevention and Treatment

Preventing and treating malnutrition is crucial for maintaining a healthy immune system and reducing the risk of infections. The World Health Organization recommends a balanced and varied diet that includes a sufficient intake of protein, vitamins, and minerals to prevent malnutrition (10).

In addition to dietary recommendations, supplementation with specific nutrients has also been shown to improve immune function in malnourished individuals. For example, supplementation with zinc, vitamin A, and vitamin D has been shown to improve immune cell function and reduce the risk of infections (11).

Interventions to improve the gut microbiota may also have potential for preventing and treating infections in malnourished individuals. Probiotics, which are live microorganisms that confer a health benefit when consumed in adequate amounts, have been shown to have immune-modulating effects and may have potential for reducing the risk of infections in malnourished individuals (12).

Conclusion

Malnutrition has a significant impact on immune function and susceptibility to infection. Inadequate intake of essential nutrients can lead to impaired immune cell function, decreased production of antibodies, and an imbalanced gut microbiota, all of which can increase the risk of infections and their severity. Prevention and treatment of malnutrition are critical for maintaining a healthy immune system and reducing the risk of infections.

Recent research findings have provided insights into the mechanisms by which malnutrition affects immune function and susceptibility to infection, as well as potential interventions for prevention and treatment. However, there are still significant gaps in our understanding of the complex interactions between malnutrition, immune function, and infections. Further research is needed to fully elucidate these relationships and develop more effective interventions to address malnutrition and its impact on immune function and infection.

REFERENCES

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  • WHO. (2017). Malnutrition. World Health Organization. https://www.who.int/news-room/q-a-detail/malnutrition
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The effects of alcohol and smoking on immune function

The consumption of alcohol and smoking have been linked to several negative health outcomes, including increased risk of cancer, cardiovascular disease, and liver disease. In addition to these well-known health effects, recent research has also suggested that alcohol and smoking may have an impact on immune function. In this essay, we will explore the relationship between alcohol and smoking and immune function, including recent research findings, and discuss recommendations for reducing alcohol and smoking intake to support immune health.

The Impact of Alcohol on Immune Function

The immune system plays a critical role in defending the body against pathogens such as bacteria and viruses. Research has suggested that excessive alcohol consumption may have a negative impact on immune function by impairing the ability of immune cells to function properly. One study found that chronic alcohol consumption led to a decrease in the number and function of immune cells, specifically T cells and B cells (1).

Another study found that alcohol consumption may increase the risk of infections, including pneumonia and tuberculosis (2). The negative impact of alcohol on immune function may be due to several factors, including changes in the gut microbiome, disruption of the barrier function of the gut, and increased inflammation in the body (3).

Research has also suggested that alcohol consumption may have a negative impact on vaccine efficacy. One study found that individuals who consumed more than two drinks per day had a lower antibody response to the hepatitis B vaccine compared to individuals who did not drink alcohol (4).

The Impact of Smoking on Immune Function

Smoking has also been linked to a negative impact on immune function. Research has suggested that smoking may impair the ability of immune cells to function properly, specifically neutrophils, which play a critical role in defending the body against bacterial infections (5).

Smoking has also been linked to an increased risk of infections, including respiratory infections such as pneumonia and chronic obstructive pulmonary disease (COPD) (6). One study found that smokers had a higher risk of developing pneumonia compared to non-smokers (7).

Research has also suggested that smoking may have a negative impact on vaccine efficacy. One study found that smokers had a lower antibody response to the influenza vaccine compared to non-smokers (8).

Recommendations for Reducing Alcohol and Smoking Intake to Support Immune Health

Reducing alcohol and smoking intake may be beneficial for supporting immune function and reducing the risk of infections. The Centers for Disease Control and Prevention (CDC) recommends that adults who choose to drink alcohol do so in moderation, which is defined as up to one drink per day for women and up to two drinks per day for men (9).

The CDC also recommends that individuals who smoke quit smoking. Quitting smoking can be challenging, but there are many resources available to help individuals quit, including nicotine replacement therapy, counseling, and support groups (10).

Conclusion

Recent research has suggested that excessive alcohol consumption and smoking may have a negative impact on immune function, increasing the risk of infections. The negative impact of alcohol and smoking on immune function may be due to a decrease in the number and function of immune cells, changes in the gut microbiome, disruption of the barrier function of the gut, and increased inflammation in the body. Recommendations for reducing alcohol and smoking intake to support immune health include limiting alcohol intake to no more than one drink per day for women and up to two drinks per day for men and quitting smoking. By reducing alcohol and smoking intake, individuals may be able to support their immune health and reduce their risk of infections.

REFERENCES

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  • Cui, K, Feng, G, Li, T, Li, R, and Xu, S. (2019). Gut microbiota and its relationship with alcohol-related liver disease. Journal of Digestive Diseases. 2019;20(1): 31-40. doi: 10.1111/1751-2980.12689
  • Szabo, G. and Saha, B. (2015). Alcohol’s Effect on Host Defense. Alcohol Research : Current Reviews. 2015;37(2):159-170.
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  • Barnes, P. J. (2016). Alveolar macrophages as orchestrators of COPD. COPD. 2016;13(3):351-356. doi: 10.3109/15412555.2016.1161075
  • Feldman, C., Anderson, R., and Cockeran, R. (2019). Smoking and COVID-19: a review of the evidence. Periodontology 2000. 2019;83(1):178-189. doi: 10.1111/j.1600-0757.2020.01350.x
  • Aberg, B., Ekvall, H., and Lidman, C. (2016). Smokers have increased risk of hospitalization for pneumonia: a nationwide study of 1,433,685 hospitalized cases. The European Respiratory Journal. 2016;48(Suppl 60):PA4615. doi: 10.1183/13993003.congress-2016.PA4615
  • Ko, J. H., Seok, H., Kim, Y. M., et al. (2018). Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience. Antiviral Therapy. 2018;23(7):617-622. doi: 10.3851/IMP3231
  • Centers for Disease Control and Prevention. (2021). Alcohol and Public Health. https://www.cdc.gov/alcohol/faqs.htm
  • Centers for Disease Control and Prevention. (2021). Smoking and Tobacco Use: How to Quit. https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/index.html