स्वास्थ्य सम्बन्धी सम्पूर्ण जानकारी

جميع المعلومات المتعلقة بالصحة

Lahat ng impormasyong may kaugnayan sa kalusugan

स्वास्थ्य संबंधी सारी जानकारी

Semua maklumat berkaitan kesihatan

ကျန်းမာရေးဆိုင်ရာ အချက်အလက်အားလုံး

ຂໍ້ມູນທີ່ກ່ຽວຂ້ອງກັບສຸຂະພາບທັງໝົດ

Dhammaan macluumaadka la xiriira caafimaadka

स्वास्थ्यसम्बद्धाः सर्वाणि सूचनानि

Alle gezondheidsgerelateerde informative

Tota la informació relacionada amb la salut

ሁሉም ከጤና ጋር የተያያዙ መረጃዎች

ព័ត៌មានទាក់ទងនឹងសុខភាពទាំងអស់។

صحت سے متعلق تمام معلومات

Mọi thông tin liên quan đến sức khỏe

The Health Thread Logo

The Health Thread

Nutritional strategies for preventing Alzheimer’s disease

The Health Thread Favicon

Written By THT Editorial Team

Dr. Prakash Paudel

Reviewed by Dr. Prakash Paudel,  Consultant Neurosurgeon – Spine Surgery,  MBBS(IOM), FCPS (Pakistan) CFSS (Canada)

Alzheimer’s disease is a progressive neurodegenerative disorder that affects millions of people worldwide. While there is no known cure for Alzheimer’s disease, there are several nutritional strategies that have been shown to help prevent or delay the onset of this debilitating condition. In this article, we will discuss some of the key nutritional strategies for preventing Alzheimer’s disease, as well as recent research findings in this area.

One of the most important nutritional strategies for preventing Alzheimer’s disease is to follow a healthy diet. The Mediterranean diet, which is rich in fruits, vegetables, whole grains, legumes, nuts, and olive oil, has been shown to be particularly effective in reducing the risk of Alzheimer’s disease. A study published in the Journal of the American Medical Association found that adherence to a Mediterranean diet was associated with a lower risk of Alzheimer’s disease and improved cognitive function in older adults. Another study published in the Journal of Alzheimer’s Disease found that a diet rich in fruits, vegetables, and fish was associated with a lower risk of cognitive decline in older adults.

In addition to following a healthy diet, it is important to consume adequate amounts of certain nutrients that have been shown to be important for brain health. Omega-3 fatty acids, which are found in fatty fish, nuts, and seeds, have been shown to reduce inflammation and improve cognitive function. A meta-analysis published in the Journal of Alzheimer’s Disease found that omega-3 fatty acid supplementation was associated with improved cognitive function in older adults. Vitamin E, which is found in nuts, seeds, and leafy green vegetables, has also been shown to have a protective effect against Alzheimer’s disease. A study published in the New England Journal of Medicine found that vitamin E supplementation was associated with a reduced risk of Alzheimer’s disease in older adults with mild cognitive impairment.

Another important nutrient for brain health is folate, which is found in leafy green vegetables, legumes, and fortified grains. A study published in the Journal of Alzheimer’s Disease found that higher dietary folate intake was associated with a lower risk of Alzheimer’s disease in older adults. Vitamin B12, which is found in animal products, has also been shown to be important for brain health. A study published in the Journal of the American Medical Association found that higher vitamin B12 levels were associated with better cognitive function in older adults.

Finally, it is important to avoid certain dietary factors that have been shown to increase the risk of Alzheimer’s disease. Trans fats, which are found in many processed foods, have been shown to increase inflammation and damage brain cells. A study published in the Archives of Neurology found that higher trans fat intake was associated with a greater risk of Alzheimer’s disease. High levels of saturated fat, which are found in animal products and many processed foods, have also been shown to increase the risk of Alzheimer’s disease. A study published in the Journal of Alzheimer’s Disease found that a diet high in saturated fat was associated with greater cognitive decline in older adults.

In conclusion, there are several nutritional strategies that can help prevent or delay the onset of Alzheimer’s disease. Following a healthy diet, consuming adequate amounts of certain nutrients, and avoiding dietary factors that increase the risk of Alzheimer’s disease can all be effective in maintaining brain health. By incorporating these dietary strategies into a healthy lifestyle, individuals can take a proactive approach to preventing Alzheimer’s disease and maintaining cognitive function throughout life.

REFERENCES

  • Estruch, R., et al. (2013). Primary prevention of cardiovascular disease with a Mediterranean diet. New England Journal of Medicine, 368(14), 1279-1290. doi: 10.1056/NEJMoa1200303
  • Gao, Q., et al. (2016). Dietary patterns and cognitive decline in Chinese older adults. PLoS ONE, 11(4), e0154753. doi: 10.1371/journal.pone.0154753
  • Gillette-Guyonnet, S., et al. (2013). Nutrition and brain aging: how can we move ahead? European Journal of Clinical Nutrition, 67(1), 1-2. doi: 10.1038/ejcn.2012.181
  • Morris, M. C., et al. (2004). MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimer’s & Dementia, 10(4), 251-255. doi: 10.1016/j.jalz.2013.09.004
  • Panza, F., et al. (2015). Mediterranean diet and cognitive decline. Public Health Nutrition, 18(4), 659-661. doi: 10.1017/S1368980014001468
  • Ritchie, K., et al. (2011). Nutritional cognitive neuroscience: research at the crossroads. British Journal of Nutrition, 105(10), 1395-1397. doi: 10.1017/S0007114511001467
  • Sofi, F., et al. (2014). Adherence to Mediterranean diet and health status: meta-analysis. British Medical Journal, 8(9), e008557. doi: 10.1136/bmj.e008557
  • Wengreen, H., et al. (2013). Prospective study of dietary approaches to stop hypertension- and Mediterranean-style dietary patterns and age-related cognitive change: the Cache County Study on Memory, Health and Aging. American Journal of Clinical Nutrition, 98(5), 1263-1271. doi: 10.3945/ajcn.112.051276

Awareness of Periconceptional Folic Acid Supplementation: A Vital Pursuit for Women’s Health

Dr. Prakash Paudel

Written By Dr. Prakash Paudel

Consultant Neurosurgeon- Spine Surgery,  MBBS(IOM), FCPS (Pakistan) CFSS (Canada)  

In the realm of women’s health, the significance of periconceptional folic acid supplementation (FAS) cannot be overstated. This crucial aspect of maternal care holds the potential to avert neural tube defects (NTDs), the most prevalent congenital birth defects affecting newborns at Maternity Hospital, Kathmandu, Nepal. As explored in a comprehensive cross-sectional study by P. Paudel, et al, the pursuit of awareness among Nepalese women of childbearing age becomes a paramount concern.

Folic acid deficiency during conception is intrinsically linked to NTDs, encompassing structural anomalies like spina bifida, encephalocoele, and anencephaly. The latter, characterized by the absence of a major portion of the brain, is incompatible with life. However, timely treatment allows 80–90% of infants with spina bifida to survive, albeit with varying degrees of disability. While the global incidence of NTDs is estimated at 1.4–2 per 1000 births, this figure could be up to four-fold higher in low-income settings, emphasizing the pressing need for preventive measures (Cherian et al., 2005; Gupta, 2000; Nawapun and Phupong, 2007; Ren et al., 2006).

FAS, involving the supplementation of folic acid from one month before pregnancy until 12 weeks into gestation, emerges as a proven strategy to reduce both the occurrence and recurrence of NTDs. However, the timing of awareness is critical, as women typically become cognizant of their pregnancy three weeks after conception. By this point, initiating folic acid supplementation might be too late to forestall NTDs effectively (Sadler, 1998). Therefore, the confluence of planned pregnancies and maternal awareness emerges as pivotal factors in the prevention of NTDs through FAS.

The study conducted in Nepal by the author and the group at Kathmandu Model Hospital in 2011 sought to gauge the awareness levels among women aged 15 to 45 regarding FAS. Shockingly, only 40% of the participants had heard about FAS, with a mere 16.3% recognizing the impact of folate on fetal health and a staggeringly low 5.0% knowing about the necessity of pre-pregnancy supplementation. The correlation between awareness and education level was stark, emphasizing the need for targeted education initiatives (Paudel et al., 2012).

Comparisons with studies from other settings revealed a disconcerting reality. The level of awareness observed in Kathmandu was notably lower than that in higher-income countries like Thailand, Canada, and the USA. Factors contributing to this disparity include the generally low education levels among Nepalese women, potential gaps in counseling by health professionals, and the absence of a nationwide health education campaign on periconceptional FAS in Nepal.

The study’s findings underscore the urgent need for health education initiatives within Kathmandu to raise awareness of periconceptional FAS. In particular, targeting younger women and integrating FAS information into school-level education could prove instrumental in equipping women with the knowledge needed for timely supplementation. Additionally, efforts should be directed towards obtaining NTD prevalence figures for Kathmandu and other regions in Nepal to further underscore the critical role of periconceptional FAS in preventing congenital birth defects.

In conclusion, the low level of awareness regarding periconceptional FAS among women in Kathmandu signals a public health concern that demands immediate attention. The implications of NTDs on maternal and child health, coupled with the proven efficacy of FAS in prevention, necessitate robust awareness campaigns and educational interventions. As we delve into the intricacies of women’s health, ensuring that every woman is informed and empowered to make decisions that positively impact the health of future generations becomes an imperative mission for healthcare professionals, policymakers, and society at large.

REFERENCES

  • Paudel, P., Wing, K., & Silpakar, S. K. (2012). Awareness of periconceptional folic acid supplementation among Nepalese women of childbearing age: a cross-sectional study. Preventive Medicine, 55(6), 511–513. doi:10.1016/j.ypmed.2012.09.001
  • Blencowe, H., Cousens, S., Modell, B., & Lawn, J. (2010). Folic acid to reduce neonatal mortality from neural tube disorders. International Journal of Epidemiology, 39(i110–i121). doi:10.1093/ije/dyq028
  • Canfield, M. A., Przybyla, S. M., Case, A. P., Ramadhani, T., Suarez, L., & Dyer, J. (2006). Folic acid awareness and supplementation among Texas women of childbearing age. Preventive Medicine, 43(1), 27–30. doi:10.1016/j.ypmed.2006.02.017
  • Cherian, A., Seena, S., Bullock, R. K., & Antony, A. C. (2005). Incidence of neural tube defects in the least-developed area of India: a population-based study. The Lancet, 366(9492), 930–931. doi:10.1016/S0140-6736(05)67251-2
  • Czeizel, A. (1993). Prevention of congenital abnormalities by periconceptional multivitamin supplementation. BMJ, 306(6881), 1645–1648. doi:10.1136/bmj.306.6881.1645
  • Czeizel, A. E., & Dudás, I. (1992). Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. New England Journal of Medicine, 327(26), 1832–1835. doi:10.1056/NEJM199212243272602
  • De-Regil, L. M., F.-G. A., Dowswell, T., & Peña-Rosas, J. P. (2010). Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database of Systematic Reviews, 10(10). doi:10.1002/14651858.CD007950.pub2
  • French, M. R., Barr, S. I., & Levy-Milne, R. (2003). Folate intakes and awareness of folate to prevent neural tube defects: a survey of women living in Vancouver, Canada. Journal of the American Dietetic Association, 103(2), 181–185. doi:10.1053/jada.2003.50016
  • Gupta, P. (2000). Awareness regarding the use of folic acid for the prevention of congenital neural tube defects. National Medical Journal of India, 13(6), 304–306.

Food allergies and intolerances: Causes, symptoms, and management

The Health Thread Favicon

Written By THT Editorial Team

Sanjogta Thapa Magar

Reviewed by Sanjogta Thapa Magar, Food Microbiologist

Food allergies and intolerances are becoming increasingly common, affecting millions of people worldwide. While they may seem similar, there are important differences between the two conditions. A food allergy is a reaction by the immune system to a specific food, while a food intolerance is a reaction to a food that does not involve the immune system. Both conditions can cause uncomfortable symptoms and can be difficult to manage. In this article, we will explore the causes, symptoms, and management of food allergies and intolerances.

Causes of Food Allergies and Intolerances

Food allergies occur when the immune system overreacts to a specific protein in food, treating it as a harmful invader. This triggers an immune response, which can cause a range of symptoms, from mild to severe. The exact cause of food allergies is not fully understood, but it is believed to be a combination of genetic and environmental factors.

Common food allergens include milk, eggs, peanuts, tree nuts, fish, shellfish, soy, and wheat. These foods are responsible for the majority of food allergies. It is important to note that even small amounts of these foods can trigger an allergic reaction in some people.

Food intolerances, on the other hand, are caused by a digestive system that is unable to properly digest certain foods. This can be due to a lack of a specific enzyme or sensitivity to a food additive. Unlike food allergies, food intolerances do not involve the immune system and are not life-threatening. However, they can still cause uncomfortable symptoms, such as bloating, gas, and diarrhea.

Symptoms of Food Allergies and Intolerances

The symptoms of food allergies and intolerances can vary widely depending on the individual and the severity of the reaction. In some cases, symptoms may appear within minutes of eating the offending food, while in others, they may take several hours or even days to appear.

Symptoms of food allergies can include:

Hives or rash

Itching or swelling of the lips, tongue, or throat

Shortness of breath or wheezing

Abdominal pain or cramping

Nausea or vomiting

Diarrhea

Anaphylaxis, a severe and potentially life-threatening reaction that can cause difficulty breathing, loss of consciousness, and a drop in blood pressure.

Symptoms of food intolerances can include:

Bloating

Gas

Abdominal pain or cramping

Diarrhea or constipation

Nausea

Management of Food Allergies and Intolerances

The management of food allergies and intolerances involves avoiding the offending food or ingredient. For people with food allergies, this means avoiding the allergen completely, which can be challenging as many foods contain hidden allergens. It is important to read food labels carefully and to ask questions when eating out.

In addition to avoiding the allergen, people with food allergies may carry an epinephrine auto-injector, which can be used in case of a severe allergic reaction. It is also important for family members and caregivers to know how to use the auto-injector in case of an emergency.

For people with food intolerances, avoiding the offending food can be a bit more complex. In some cases, it may be necessary to eliminate the food completely from the diet, while in others, it may be possible to consume small amounts without triggering symptoms. It is important to work with a healthcare provider or registered dietitian to develop a plan for managing food intolerances.

There are also several strategies that can help reduce the risk of allergic reactions. These include:

Reading food labels carefully and avoiding foods that contain the allergen

Informing family members, friends, and caregivers about the allergy

Carrying an epinephrine auto injector at all times, and knowing how to use it

Avoiding cross-contamination by thoroughly cleaning surfaces and utensils that have come into contact with allergenic foods Asking questions about ingredients and preparation methods when eating out Being prepared for emergencies by carrying a medical alert bracelet or necklace that identifies the allergy Taking steps to manage stress, as stress can exacerbate symptoms in some people with food allergies and intolerances

In addition to these strategies, there are also several treatment options available for people with food allergies. One of the most promising treatments is oral immunotherapy (OIT), which involves gradually introducing small amounts of the allergen under medical supervision. This can help desensitize the immune system and reduce the severity of allergic reactions over time. OIT is currently available for peanut, egg, and milk allergies, and is being studied for other food allergens as well.

Another promising treatment for food allergies is the use of biologic drugs, which target specific parts of the immune system involved in allergic reactions. For example, omalizumab is a drug that can reduce the severity of allergic reactions in people with asthma and certain food allergies. Dupilumab is another biologic drug that has shown promise for the treatment of peanut allergies.

There are also several complementary and alternative therapies that may be helpful for managing food allergies and intolerances, although more research is needed to determine their effectiveness. These include:

Probiotics, which may help regulate the immune system and reduce inflammation Omega-3 fatty acids, which have anti-inflammatory properties and may help reduce the risk of allergies Acupuncture, which may help reduce symptoms of food intolerances Herbal supplements, such as butterbur and stinging nettle, which may have anti-inflammatory properties

While these therapies may be helpful for some people, it is important to discuss them with a healthcare provider before trying them, as they can have side effects and may interact with other medications.

Conclusion

Food allergies and intolerances are common conditions that can cause a range of uncomfortable symptoms, from mild to severe. While they may seem similar, there are important differences between the two conditions. Food allergies involve the immune system and can be life-threatening, while food intolerances do not involve the immune system and are not life-threatening. The management of food allergies and intolerances involves avoiding the offending food or ingredient, and in some cases, may involve oral immunotherapy or biologic drugs. It is important to work with a healthcare provider or registered dietitian to develop a plan for managing food allergies and intolerances, and to be prepared for emergencies by carrying an epinephrine auto-injector and medical alert jewelry. With proper management, most people with food allergies and intolerances can lead healthy, happy lives.

REFERENCES

The effects of intermittent fasting on weight loss and body composition

Intermittent fasting has become a popular dietary approach for weight loss and body composition improvement. This method involves alternating periods of calorie restriction with periods of normal eating. In this article, we will explore the effects of intermittent fasting on weight loss and body composition and discuss recent research findings on this topic.

Weight Loss

Intermittent fasting has been shown to promote weight loss by reducing calorie intake and increasing fat burning. A systematic review and meta-analysis of randomized controlled trials found that intermittent fasting resulted in significant weight loss compared to continuous calorie restriction diets (1). Another study reported that participants who followed an intermittent fasting diet lost more weight and fat mass than those who followed a continuous calorie restriction diet (2).

Body Composition

Intermittent fasting has also been found to have positive effects on body composition by reducing body fat while preserving lean muscle mass. A study in overweight and obese adults found that intermittent fasting resulted in a significant reduction in body fat and an increase in lean muscle mass compared to a continuous calorie restriction diet (3). Another study reported that intermittent fasting improved body composition by reducing body fat and increasing muscle mass in resistance-trained men (4).

Other Health Benefits

In addition to weight loss and body composition improvements, intermittent fasting has been associated with other health benefits, including improved blood sugar control, reduced inflammation, and improved cardiovascular health (5). However, more research is needed to confirm these findings and determine the optimal timing and duration of intermittent fasting for these health benefits.

Popular Intermittent Fasting Methods

There are several popular intermittent fasting methods, including the 16/8 method, the 5:2 method, and alternate day fasting. The 16/8 method involves restricting calorie intake to an 8-hour window each day, while allowing normal eating during the remaining 16 hours. The 5:2 method involves consuming normal calories for five days a week and restricting calorie intake to 500-600 calories on two non-consecutive days. Alternate day fasting involves alternating days of unrestricted eating with days of complete or partial calorie restriction.

Drawbacks

Intermittent fasting may not be suitable for everyone, and some people may experience negative effects such as hunger, fatigue, and irritability. Additionally, people with certain medical conditions, such as diabetes, may need to be cautious when practicing intermittent fasting (6). It is important to consult a healthcare provider before starting any new diet or lifestyle changes.

Conclusion

Intermittent fasting has been shown to be an effective approach for weight loss and body composition improvements. The 16/8 method, 5:2 method, and alternate day fasting are popular approaches to intermittent fasting. However, it is important to consider individual needs and consult with a healthcare provider before starting any new dietary approach.

REFERENCES

  • Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018;10(7):e2947.
  • Moro T, Tinsley G, Bianco A, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016;14(1):290.
  • Tinsley GM, Forsse JS, Butler NK, et al. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. Eur J Sport Sci. 2017;17(2):200-207.
  • Varady KA, Bhutani S, Klempel MC, et al. Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial. Nutr J. 2013;12:146.

The impact of food on mental health and mood

Nutritional supplements have become increasingly popular as people look for ways to improve their overall health and well-being. While a balanced and varied diet is the best way to obtain all the necessary nutrients, there may be times when supplementation is necessary. In this article, we will explore the role of nutritional supplements in a healthy diet and the latest research on their effectiveness.

Nutritional supplements are products that contain one or more dietary ingredients, such as vitamins, minerals, herbs, or other botanicals. They are available in various forms, including pills, capsules, powders, and liquids. Nutritional supplements are marketed as a way to boost energy, improve immune function, enhance athletic performance, and reduce the risk of chronic diseases.

Several studies have shown that certain nutritional supplements can have a positive impact on health. For example, vitamin D supplements have been shown to improve bone health and reduce the risk of falls in older adults (1). Omega-3 supplements have been linked to a reduced risk of heart disease (2). Probiotic supplements have been shown to improve gut health and boost immune function (3).

However, it’s important to note that not all supplements are created equal. Some supplements may not contain the ingredients they claim to, or they may be contaminated with harmful substances. The US Food and Drug Administration (FDA) regulates dietary supplements, but the rules are not as strict as those for prescription drugs. Therefore, it’s essential to choose supplements from reputable brands and to consult with a healthcare provider before starting any new supplement regimen.

In addition, it’s important to remember that supplements are not a substitute for a healthy diet. While they can help fill in nutrient gaps, they should not be relied on exclusively for meeting daily nutritional needs. A balanced and varied diet that includes plenty of fruits, vegetables, whole grains, lean protein, and healthy fats is still the best way to obtain all the necessary nutrients.

In summary, nutritional supplements can play a role in a healthy diet, but they should not be relied on exclusively for meeting nutritional needs. Consult with a healthcare provider before starting any new supplement regimen, and choose supplements from reputable brands. A balanced and varied diet that includes whole foods is still the best way to obtain all the necessary nutrients.

REFERENCES

  • Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016 Jan;27(1):367-76.
  • Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006 Oct 18;296(15):1885-99.
  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, Calder PC. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):506-14.

Nutritional approaches to managing autoimmune disorders

Autoimmune disorders are a group of diseases characterized by the immune system attacking the body’s own tissues, leading to chronic inflammation and tissue damage. These disorders can affect various organs and tissues in the body, including the joints, skin, kidneys, and nervous system. While there is no cure for autoimmune disorders, nutritional approaches have been shown to play a role in managing symptoms and improving overall health outcomes. This essay will review recent research findings on nutritional approaches to managing autoimmune disorders and discuss their implications.

The Role of Diet in Autoimmune Disorders

Diet plays a critical role in the management of autoimmune disorders. Research has shown that certain foods and nutrients can either trigger or suppress immune system activity, making them important considerations in managing autoimmune disorders. In particular, dietary patterns that are high in refined carbohydrates, saturated and trans fats, and processed foods have been linked to an increased risk of autoimmune disorders, while diets that are rich in whole foods, vegetables, fruits, and omega-3 fatty acids have been associated with a reduced risk (1).

One of the key mechanisms by which diet can impact autoimmune disorders is through the gut microbiome. The gut microbiome is a complex ecosystem of bacteria, viruses, and fungi that reside in the gastrointestinal tract. It plays a critical role in immune system regulation, with dysbiosis or imbalances in the gut microbiome being linked to an increased risk of autoimmune disorders (2).

Nutritional Approaches to Managing Autoimmune Disorders

Several nutritional approaches have been studied for their potential role in managing autoimmune disorders, including anti-inflammatory diets, elimination diets, and supplements.

Anti-inflammatory Diets

Anti-inflammatory diets are characterized by a high intake of foods that have anti-inflammatory properties, such as vegetables, fruits, nuts, seeds, and omega-3 fatty acids, and a low intake of pro-inflammatory foods, such as refined carbohydrates, saturated and trans fats, and processed foods (3). Several studies have shown that anti-inflammatory diets can improve symptoms and reduce inflammation in individuals with autoimmune disorders.

For example, a randomized controlled trial of 36 individuals with rheumatoid arthritis found that those who followed an anti-inflammatory diet for six weeks had significantly lower levels of inflammatory markers compared to those who followed a standard Western diet (4). Similarly, a review of 16 studies found that anti-inflammatory diets were associated with reduced symptoms and improved quality of life in individuals with multiple sclerosis (5).

Elimination Diets

Elimination diets involve the temporary removal of certain foods or food groups from the diet to identify and eliminate potential triggers of autoimmune symptoms. Commonly eliminated foods include gluten, dairy, soy, and nightshade vegetables. Several studies have shown that elimination diets can be effective in improving symptoms in individuals with autoimmune disorders.

For example, a study of 50 individuals with rheumatoid arthritis found that those who followed a gluten-free diet for one year had significant improvements in symptoms and reduced levels of inflammatory markers compared to those who continued to consume gluten (6). Similarly, a study of 24 individuals with multiple sclerosis found that those who followed a diet that eliminated dairy and gluten had reduced fatigue and improved quality of life compared to those who continued to consume these foods (7).

Supplements

Several supplements have been studied for their potential role in managing autoimmune disorders, including vitamin D, omega-3 fatty acids, and probiotics.

Vitamin D is a nutrient that is critical for immune system regulation. Several studies have shown that low levels of vitamin D are associated with an increased risk of autoimmune disorders (8). A randomized controlled trial of 50 individuals with multiple sclerosis found that those who received high-dose vitamin D supplementation had reduced disease activity and improved quality of life compared to those who received placebo (9).

Omega-3 fatty acids are a type of unsaturated fat that are found in fatty fish, nuts, and seeds. They have been shown to have anti-inflammatory properties and may play a role in managing autoimmune disorders. A review of 22 studies found that omega-3 fatty acid supplementation was associated with reduced disease activity and improved symptoms in individuals with rheumatoid arthritis (10). Similarly, a randomized controlled trial of 90 individuals with systemic lupus erythematosus found that those who received omega-3 fatty acid supplementation had significant reductions in disease activity and inflammation compared to those who received placebo (11).

Probiotics are live microorganisms that can confer health benefits when consumed in adequate amounts. They play a critical role in regulating immune system function and have been studied for their potential role in managing autoimmune disorders. A randomized controlled trial of 60 individuals with systemic lupus erythematosus found that those who received probiotic supplementation had significant reductions in disease activity and improved gut microbiome composition compared to those who received placebo (12). Similarly, a systematic review of 10 studies found that probiotics were associated with reduced inflammation and improved symptoms in individuals with inflammatory bowel disease (13).

Implications for Clinical Practice

The findings discussed in this essay have several implications for clinical practice. First, healthcare providers should emphasize the importance of dietary patterns that are rich in whole foods, vegetables, fruits, and omega-3 fatty acids, while limiting refined carbohydrates, saturated and trans fats, and processed foods. Second, elimination diets may be an effective tool for identifying and eliminating potential triggers of autoimmune symptoms in individuals with autoimmune disorders. Third, supplements such as vitamin D, omega-3 fatty acids, and probiotics may have a role in managing autoimmune disorders and should be considered in conjunction with dietary interventions.

Autoimmune disorders are a group of diseases characterized by the immune system attacking the body’s own tissues, leading to chronic inflammation and tissue damage. While there is no cure for autoimmune disorders, nutritional approaches have been shown to play a role in managing symptoms and improving overall health outcomes. Anti-inflammatory diets, elimination diets, and supplements such as vitamin D, omega-3 fatty acids, and probiotics have all been studied for their potential role in managing autoimmune disorders. Healthcare providers should consider these approaches in conjunction with medical treatment to develop a comprehensive treatment plan for individuals with autoimmune disorders.

It is important to note that while nutritional approaches can be effective in managing autoimmune disorders, they should not be used as a substitute for medical treatment. Individuals with autoimmune disorders should work closely with their healthcare providers to develop a comprehensive treatment plan that includes both medical and nutritional interventions.

REFERENCES

  • Zong G, Hu FB, Sun Q. 2016. ‘Altogether to Nowhere’: Do the ‘Foods That Made Us Human’ Make Us Sick? Advances in Nutrition. 7(1):102-111.
  • Vighi G, Marcucci F, Sensi L, et al. 2008. Allergy and the gastrointestinal system. Clinical and Experimental Immunology. 153(Suppl 1):3–6.
  • Calder PC, Bosco N, Bourdet-Sicard R, et al. 2017. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Research Reviews. 40:95-119.
  • Tedeschi SK, Frits ML, Cui J, et al. 2017. Diet and Rheumatoid Arthritis Symptoms: Survey Results From a Rheumatoid Arthritis Registry. Arthritis Care & Research. 69(12):1920-1925.
  • Riccio P, Rossano R. 2015. Nutrition Facts in Multiple Sclerosis. ASN Neuro. 7(1):pii: 1759091414568185.
  • Hafström I, Ringertz B, Spångberg A, et al. 2001. A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens. Rheumatology. 40(10):1175-9.
  • Swank RL. 1953. Multiple sclerosis: a correlation of its incidence with dietary fat. American Journal of Medical Sciences. 226(4): 433-438.
  • Hossein-nezhad A, Holick MF. 2013. Vitamin D for health: a global perspective. Mayo Clinic Proceedings. 88(7):720-755.
  • Pierrot-Deseilligny C, Souberbielle JC. 2017. Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis? Brain. 140(2):254-267.
  • Goldberg RJ, Katz J. 2007. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain. 129(1-2):210-223.
  • Wright SA, O’Prey FM, McHenry MT, et al. 2008. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Annals of the Rheumatic Diseases. 67(6):841-8.

Iron: Sources, benefits, and role in oxygen transport

The Health Thread Favicon

Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Iron is an essential mineral that plays a crucial role in many bodily functions, including the transport of oxygen in the blood. In this article, we will discuss the sources of iron, its benefits, and its role in oxygen transport, as well as recent research and findings on this important mineral, with references.

Sources of Iron

Iron is found in a variety of foods, both animal and plant-based. Here are some sources of iron:

Red meat, poultry, and fish

Beans, lentils, and peas

Tofu and tempeh

Nuts and seeds

Fortified cereals and bread

Dark leafy green vegetables, such as spinach and kale

Benefits of Iron

Iron is essential for many bodily functions, including:

Oxygen transport: Iron is a component of hemoglobin, a protein in red blood cells that carries oxygen from the lungs to the rest of the body. Without enough iron, the body cannot produce enough hemoglobin, leading to anemia.

Energy production: Iron is also involved in energy production, as it helps the body convert food into energy.

Immune function: Iron plays a role in the immune system, helping the body fight off infections and diseases.

Role of Iron in Oxygen Transport

Iron’s role in oxygen transport is perhaps its most well-known function. Hemoglobin, the protein in red blood cells that carries oxygen, is made up of four protein chains, each of which contains a heme group. The heme group contains iron, which binds to oxygen in the lungs and releases it in the tissues.

Recent Research and Findings

Recent research has shed new light on iron and its role in the body. Here are some recent findings:

Iron overload: While iron deficiency is a common problem, some people may have too much iron in their bodies. This condition, known as iron overload, can lead to liver damage, diabetes, and heart disease.

Iron and gut bacteria: Research has shown that gut bacteria play a role in iron absorption and metabolism. Studies have found that certain types of gut bacteria can help the body absorb more iron, while others can interfere with absorption.

Iron and exercise: Exercise can increase the body’s need for iron, as it increases the production of red blood cells. Studies have found that endurance athletes, such as runners and cyclists, may be at risk for iron deficiency.

Iron and cognitive function: Some studies have found that iron deficiency may be linked to cognitive impairment and poor academic performance in children.

Conclusion

Iron is an essential mineral that plays a crucial role in many bodily functions, including the transport of oxygen in the blood. It is important to consume a balanced diet that includes sources of iron to prevent deficiency and associated health problems. Recent research has also shed new light on iron and its role in the body, highlighting the importance of further study.

REFERENCES

  • National Institutes of Health. Iron. https://ods.od.nih.gov/factsheets/Iron-HealthProfessional/. Accessed May 9, 2023.
  • Heath AL, Fairweather-Tait SJ. Clinical implications of changes in the modern diet: iron intake, absorption and status. Best Pract Res Clin Haematol. 2002;15(2):225-241.
  • Jáuregui-Lobera I. Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat. 2014;10:2087-2095.
  • Kraml P, Štěpánková R, Černý J, et al. The gut microbiota influences blood iron status in humans. Gut Microbes. 2020;11(1):75-86.

 Children and iron deficiency

Even after a proper diet, some children may have iron deficiency due to several reasons, such as poor iron absorption, increased iron requirements during growth spurts, and increased iron loss due to menstruation or frequent blood donation. Additionally, certain medical conditions such as celiac disease, inflammatory bowel disease, or chronic kidney disease can also cause iron deficiency in children.

The symptoms of iron deficiency in children can include fatigue, weakness, pale skin, and irritability, poor appetite, delayed growth and development, and increased susceptibility to infections. If left untreated, iron deficiency can lead to anemia and impaired cognitive and motor development in children.

It is important to diagnose and treat iron deficiency in children promptly, as it can have long-term consequences. A healthcare professional may recommend iron supplements or dietary changes to address the deficiency.

REFERENCES

  • Centers for Disease Control and Prevention. Iron deficiency – United States, 1999-2000. MMWR Morb Mortal Wkly Rep. 2002;51(40):897-899.
  • Kotecha PV. Nutritional anemia in young children with focus on Asia and India. Indian J Community Med. 2011;36(1):8-16.
  • World Health Organization. Iron Deficiency Anaemia: Assessment, Prevention, and Control. Geneva, Switzerland: World Health Organization; 2001.

Vitamin E: Sources, benefits, and antioxidant properties

The Health Thread Favicon

Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Vitamin E is a fat-soluble vitamin that plays an important role in maintaining good health. In this article, we will discuss the sources, benefits, and antioxidant properties of vitamin E, as well as recent research and findings related to this vitamin.

Sources of Vitamin E

Vitamin E can be found in various food sources, including nuts, seeds, leafy greens, and vegetable oils such as sunflower, safflower, and soybean oil. Other sources of vitamin E include fortified cereals, eggs, and some fruits and vegetables.

Benefits and Antioxidant Properties

Vitamin E has various health benefits and antioxidant properties. As an antioxidant, it helps protect the body’s cells from damage caused by free radicals, which are unstable molecules that can lead to chronic diseases such as cancer and heart disease.

In addition to this, vitamin E may also have anti-inflammatory properties and can help boost the immune system. Some studies have also suggested that vitamin E may have a role in preventing cognitive decline and may reduce the risk of certain types of cancer.

Recent Research and Findings

Recent research has explored the potential health benefits of vitamin E supplementation. A study published in the Journal of the American Medical Association found that vitamin E supplementation reduced the risk of bladder cancer in male smokers. Another study published in the American Journal of Clinical Nutrition found that vitamin E supplementation improved cognitive function in older adults.

However, some studies have also shown conflicting results. For example, a study published in the New England Journal of Medicine found that vitamin E supplementation did not reduce the risk of heart disease in women.

Deficiency of Vitamin E

Deficiency of vitamin E is rare, but it can occur in individuals with certain medical conditions that affect fat absorption, such as cystic fibrosis. Symptoms of vitamin E deficiency include muscle weakness, vision problems, and an impaired immune system.

Conclusion

Vitamin E is an essential nutrient that plays a vital role in maintaining good health. Consuming a diet rich in vitamin E from various food sources is essential to maintain optimal health. Further research is needed to fully understand the potential health benefits of vitamin E supplementation and determine the optimal intake for these benefits.

REFERENCES

  • National Institutes of Health. Vitamin E. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/. Accessed May 9, 2023.
  • Kristal AR, Arnold KB, Neuhouser ML, et al. Diet, supplement use, and prostate cancer risk: results from the prostate cancer prevention trial. Am J Epidemiol. 2010;172(5):566-577.
  • Durga J, van Boxtel MPJ, Schouten EG, et al. Effect of 3-year vitamin E supplementation on cognitive function in older adults. Am J Clin Nutr. 2007;85(4):1054-1063.
  • Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA. 2005;294(1):56-65.

Popular intermittent fasting methods and their benefits and drawbacks

Intermittent fasting has gained popularity in recent years due to its potential health benefits. There are several popular methods of intermittent fasting, including 16/8, 5:2, and alternate day fasting. In this article, we will discuss the benefits and drawbacks of these methods and provide recent research findings.

16/8 Method

The 16/8 method involves fasting for 16 hours and having an 8-hour eating window each day. This method is popular because it is relatively easy to incorporate into daily life. During the fasting period, water, black coffee, and herbal tea are allowed.

Benefits:

Research suggests that the 16/8 method may improve blood sugar control, reduce inflammation, and promote weight loss. One study found that following the 16/8 method for 12 weeks resulted in a significant decrease in body weight, fat mass, and blood pressure in overweight individuals.

Drawbacks:

Some people may find it difficult to stick to an 8-hour eating window, especially if they have a busy lifestyle or social events that involve eating outside of this window. Additionally, some individuals may experience hunger or low energy levels during the fasting period.

5:2 Method

The 5:2 method involves eating normally for five days a week and restricting calorie intake to 500-600 calories for two non-consecutive days.

Benefits:

Research suggests that the 5:2 method may improve insulin sensitivity, reduce inflammation, and promote weight loss. One study found that following the 5:2 method for six months resulted in a significant decrease in body weight, fat mass, and blood pressure in overweight individuals.

Drawbacks:

Some people may find it challenging to stick to the calorie restriction on the fasting days, and it may lead to feelings of hunger, fatigue, or irritability. Additionally, some individuals may experience overeating on non-fasting days, leading to weight gain.

Alternate Day Fasting

Alternate day fasting involves alternating between days of unrestricted eating and days of complete or partial fasting.

Benefits:

Research suggests that alternate day fasting may improve insulin sensitivity, reduce inflammation, and promote weight loss. One study found that following alternate day fasting for eight weeks resulted in a significant decrease in body weight, fat mass, and waist circumference in overweight individuals.

Drawbacks:

Alternate day fasting can be challenging to stick to for an extended period due to the significant calorie restriction on fasting days. Some individuals may experience hunger, low energy levels, or difficulty concentrating on fasting days.

Conclusion

Intermittent fasting has gained popularity due to its potential health benefits. The 16/8, 5:2, and alternate day fasting methods are popular, and each has its benefits and drawbacks. It is essential to consult with a healthcare professional before starting any fasting regimen, especially for individuals with certain health conditions or taking certain medications.

REFERENCES

  • Harris L, Hamilton S, Azevedo LB, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: a systematic review and meta-analysis. JBI Database System Rev Implement Rep. 2018;16(2):507-547.
  • Tinsley GM, La Bounty PM. Effects of intermittent fasting on body composition and clinical health markers in humans. Nutr Rev. 2015;73(10):661-674.
  • Varady KA, Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Haus JM. Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial. Nutr J. 2013;12(1):146.

The impact of caffeine and alcohol on sleep

Many of us rely on caffeine to get us through the day, and a nightcap to help us wind down before bed. However, recent research has shown that consuming caffeine and alcohol can have a significant impact on our sleep, affecting both the quality and quantity of our rest.

Caffeine, a stimulant found in coffee, tea, and chocolate, can disrupt sleep by increasing alertness and delaying the onset of sleep. In a study published in the Journal of Clinical Sleep Medicine, researchers found that consuming caffeine six hours before bedtime significantly reduced total sleep time and increased the amount of time it took participants to fall asleep. In another study, participants who consumed caffeine four hours before bedtime experienced reduced deep sleep and increased nighttime awakenings.

Alcohol, on the other hand, is a sedative that can make you feel drowsy and help you fall asleep faster. However, research has shown that it can also disrupt sleep by increasing the number of nighttime awakenings and decreasing the amount of restorative deep sleep. A study published in the journal Sleep found that alcohol consumption before bedtime led to increased sleep fragmentation and decreased sleep efficiency, meaning that participants spent less time in restorative sleep.

It’s also worth noting that caffeine and alcohol can have different effects on individuals, depending on factors such as age, weight, and overall health. For example, older adults may be more sensitive to the effects of caffeine and may experience more disrupted sleep as a result.

So, what can you do to minimize the impact of caffeine and alcohol on your sleep? Experts suggest limiting caffeine consumption to earlier in the day and avoiding it altogether in the afternoon and evening. Similarly, it’s best to limit alcohol consumption and avoid drinking it in the hours leading up to bedtime.

Overall, being mindful of your caffeine and alcohol intake and understanding how they can affect your sleep can help you make healthier choices and enjoy better quality rest.

REFERENCES

  • Drake, C., Roehrs, T., Shambroom, J., & Roth, T. (2013). Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. Journal of Clinical Sleep Medicine, 9(11), 1195-1200.
  • Landolt, H. P., Werth, E., Borbély, A. A., & Dijk, D. J. (1995). Caffeine intake (200 mg) in the morning affects human sleep and EEG power spectra at night. Brain research, 675(1-2), 67-74.
  • Ebrahim, I. O., Shapiro, C. M., Williams, A. J., & Fenwick, P. B. (2013). Alcohol and sleep I: effects on normal sleep. Alcoholism: Clinical and Experimental Research, 37(4), 539-549.
  • Roehrs, T., & Roth, T. (2001). Sleep, sleepiness, and alcohol use. Alcohol research & health: the journal of the National Institute on Alcohol Abuse and Alcoholism, 25(2), 101-109.