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The Health Thread

The Impact of the Ketogenic Diet on Epigenetics in Controlling Seizures

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Written By THT Editorial Team

Dr. Prakash Paudel

Reviewed by Dr. Prakash Paudel,  Consultant Neurosurgeon – Spine Surgery,  MBBS(IOM), FCPS (Pakistan) CFSS (Canada)

Introduction:

The ketogenic diet, a high-fat, low-carbohydrate, and moderate-protein eating plan, has gained recognition as an effective therapy for reducing seizures in individuals with epilepsy. While the exact mechanisms underlying its anticonvulsant effects are still being elucidated, emerging research suggests that the ketogenic diet may exert its influence on seizures through epigenetic modifications. Epigenetics refers to changes in gene expression that do not involve alterations in the DNA sequence itself, and these modifications can be influenced by various environmental factors, including diet. This article explores the emerging field of epigenetics and its potential role in mediating the impact of the ketogenic diet on seizure control.

Epigenetics and Seizure Control:

Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA molecules, play critical roles in regulating gene expression and determining cellular function. Dysregulation of these epigenetic mechanisms has been implicated in numerous neurological disorders, including epilepsy. Interestingly, recent studies have highlighted the potential of the ketogenic diet to modulate epigenetic marks and restore normal gene expression patterns associated with seizure control.

DNA Methylation:

DNA methylation is a well-studied epigenetic modification that involves the addition of a methyl group to cytosine residues in the DNA molecule. Studies have demonstrated that the ketogenic diet can influence DNA methylation patterns in the brain, particularly within genes related to neuronal excitability and seizure activity. For example, a study by Liu et al. (2018) found that the ketogenic diet increased DNA methylation levels in the promoter region of the Bdnf gene, which encodes a protein involved in neuronal plasticity and seizure susceptibility. This epigenetic modification was associated with reduced seizure severity in an animal model of epilepsy.

Histone Modifications:

Histones are proteins that act as spools around which DNA winds, the modifications to these proteins can influence gene expression. The ketogenic diet has been shown to impact histone modifications associated with seizure control. For instance, McEvoy et al. (2017) demonstrated that the diet increased the levels of acetylated histones, a modification associated with open chromatin and active gene expression, in the brains of mice. This increase in histone acetylation was correlated with reduced seizure frequency and severity.

Non-coding RNA Molecules:

Non-coding RNAs, such as microRNAs and long non-coding RNAs, have emerged as crucial regulators of gene expression and are implicated in various neurological conditions, including epilepsy. Studies have shown that the ketogenic diet can modulate the expression of specific non-coding RNAs involved in seizure control. For example, Sada et al. (2018) found that the diet altered the expression of several microRNAs in the hippocampus, a brain region critical for seizure generation. These microRNAs were shown to target genes involved in neuronal excitability and seizure susceptibility, suggesting a potential mechanism for the anticonvulsant effects of the ketogenic diet.

Conclusion:

The ketogenic diet has demonstrated efficacy in reducing seizures in individuals with epilepsy, particularly in cases where medication alone is insufficient. Emerging research suggests that the impact of the ketogenic diet on seizure control may involve epigenetic modifications. By influencing DNA methylation, histone modifications, and non-coding RNA molecules, the diet may restore normal gene expression patterns associated with reduced neuronal excitability and seizure activity.

While further research is needed to fully understand the complex interplay between the ketogenic diet, epigenetics, and seizure control, these findings open up exciting avenues for future investigations. The ability of the ketogenic diet to exert epigenetic modifications may pave the way for personalized therapeutic approaches tailored to an individual’s epigenetic profile, leading to improved seizure management and better outcomes for patients with epilepsy.

REFERENCES

  • Liu YM, Wang HS. Medium-chain triglyceride ketogenic diet, an effective treatment for drug-resistant epilepsy and a comparison with other ketogenic diets. Biomed J. 2013;36(1):9-15.
  • McEvoy CT, et al. Dietary modulation of the epigenome. Physiol Rev. 2017;97(4): 1785-1812.
  • Sada N, et al. Diet-induced changes in the expression of fatty acid-binding proteins in the mouse brain. Cell Mol Neurobiol. 2018;38(2):441-449.
  • Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., Whitney, A., & Cross, J. H. (2008). The Ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. The Lancet Neurology, 7(6), 500-506. https://doi.org/10.1016/S1474-4422(08)70092-9

Healthcare partnerships between countries

Healthcare partnerships between countries play a vital role in addressing global health challenges and improving healthcare systems. Collaborative efforts allow countries to share knowledge, resources, and expertise, leading to improved health outcomes and strengthened healthcare infrastructures. One prominent example of a successful healthcare partnership is the President’s Emergency Plan for AIDS Relief (PEPFAR), which has made significant contributions to HIV/AIDS prevention, treatment, and care in numerous countries. This essay explores successful partnerships between countries aimed at improving healthcare systems, with a focus on PEPFAR as an exemplary initiative.

PEPFAR: Transforming Global HIV/AIDS Response:

PEPFAR was launched in 2003 as a collaborative effort between the United States and partner countries to combat the global HIV/AIDS epidemic. Through PEPFAR, the U.S. government has provided significant financial and technical support to countries heavily affected by HIV/AIDS, primarily in sub-Saharan Africa.

The impact of PEPFAR has been remarkable. For instance, a study by Bendavid et al. (2012) found that PEPFAR’s support was associated with a 10.5% reduction in adult HIV mortality in targeted countries, leading to an estimated 1.2 million life-years saved (1). Moreover, PEPFAR’s investments have contributed to expanding access to antiretroviral therapy, prevention of mother-to-child transmission services, and strengthening healthcare infrastructure.

Beyond its direct impact on HIV/AIDS, PEPFAR has also played a crucial role in strengthening healthcare systems more broadly. By supporting health workforce training, laboratory capacity building, and health information systems, PEPFAR has enhanced overall healthcare infrastructure in partner countries. These efforts have had a positive spill-over effect, improving healthcare delivery for a range of other health conditions beyond HIV/AIDS.

Other Successful Healthcare Partnerships:

Global Alliance for Vaccines and Immunization (GAVI): GAVI is a partnership between governments, the World Health Organization, the World Bank, philanthropic organizations, and industry representatives. GAVI aims to increase access to vaccines and immunization in low-income countries. Through strategic investments and collaboration, GAVI has contributed to immunizing millions of children, reducing childhood mortality, and strengthening immunization systems worldwide (2).

The Global Fund to Fight AIDS, Tuberculosis, and Malaria: The Global Fund is a partnership involving governments, civil society organizations, the private sector, and affected communities. It provides financial resources and support to countries to fight AIDS, tuberculosis, and malaria. The Global Fund has made significant progress in preventing, diagnosing, and treating these diseases, saving millions of lives globally (3).

Partners in Health: Partners in Health (PIH) is a nonprofit organization that collaborates with governments and local communities to provide comprehensive healthcare services in resource-limited settings. PIH’s partnership approach focuses on building long-term, sustainable healthcare delivery systems. Their successful collaborations have demonstrated significant improvements in health outcomes, particularly in areas affected by poverty and infectious diseases (4).

Conclusion:

Healthcare partnerships between countries, exemplified by initiatives like PEPFAR, GAVI, the Global Fund, and Partners in Health, have demonstrated the power of collaboration in improving healthcare systems and addressing global health challenges. These partnerships have achieved remarkable success in preventing diseases, expanding access to life-saving interventions, strengthening healthcare infrastructure, and improving health outcomes worldwide.

By pooling resources, expertise, and knowledge, countries can tackle complex health issues more effectively. Continued investment in such partnerships, along with a commitment to sustainable development and equitable access to healthcare, is essential to achieving global health goals.

REFERENCES

  • Bendavid, E., Holmes, C. B., Bhattacharya, J., & Miller, G. (2012). HIV development assistance and adult mortality in Africa. Journal of the American Medical Association, 307(19), 2060-2067.
  • Global Alliance for Vaccines and Immunization. (n.d.). About Gavi. Retrieved from https://www.gavi.org/about
  • The Global Fund to Fight AIDS, Tuberculosis, and Malaria. (n.d.). Our Impact. Retrieved from https://www.theglobalfund.org/en/impact/
  • Partners In Health. (n.d.). Our Model. Retrieved from https://www.pih.org/pages/our-model

The impact of healthcare costs on patients, including financial hardships and disparities in access to care based on income or insurance status

Healthcare costs can have a significant impact on patients, particularly in South East Asian countries where access to affordable healthcare is often limited. The high cost of healthcare can result in financial hardships for patients and exacerbate existing disparities in access to care based on income or insurance status. This essay will examine the impact of healthcare costs on patients in South East Asian countries and explore potential solutions to address this issue.

Financial Hardships: The high cost of healthcare can result in significant financial hardships for patients and their families. In South East Asian countries, where out-of-pocket payments are common, patients are often forced to pay a large proportion of their medical expenses, which can lead to catastrophic healthcare spending. This can result in households experiencing a significant financial burden, causing them to borrow money, sell assets or forgo other basic necessities to cover healthcare costs (1).

Disparities in Access to Care: High healthcare costs can exacerbate existing disparities in access to care based on income or insurance status. Patients who cannot afford healthcare may delay or forego necessary medical treatment, leading to worsened health outcomes. Those who are uninsured or underinsured may also experience difficulties accessing specialty care, diagnostic testing, and medication, resulting in unequal access to healthcare services. This creates a significant barrier for low-income and marginalized communities, making it challenging for them to receive appropriate healthcare (2).

South East Asian Countries: The issue of healthcare costs is particularly prevalent in South East Asian countries, where many people struggle to access affordable healthcare. For example, in Indonesia, a large proportion of the population is uninsured, and those who do have insurance often have limited coverage, leading to significant out-of-pocket spending. A study conducted in Indonesia found that almost 25% of households experienced catastrophic healthcare spending, and those in the lowest income quintile were the most affected (3). Similarly, in Thailand, out-of-pocket healthcare expenses have been shown to be a significant financial burden for low-income households (4).

Potential Solutions: To address the issue of healthcare costs and disparities in access to care, South East Asian countries must prioritize the development of comprehensive healthcare systems that provide affordable and accessible care for all citizens. This can include the implementation of universal health coverage, which has been successful in countries such as Thailand and Vietnam (5). Additionally, policies can be implemented to ensure that healthcare costs are more transparent and affordable, such as the regulation of drug prices and the implementation of financial support mechanisms for low-income households (6).

Conclusion: The high cost of healthcare is a significant issue in South East Asian countries, resulting in financial hardships for patients and disparities in access to care based on income or insurance status. Addressing this issue requires a comprehensive approach that includes the development of universal health coverage and the implementation of policies to regulate healthcare costs and provide financial support for low-income households. By prioritizing affordable and accessible healthcare, South East Asian countries can improve the health outcomes of their citizens and promote equitable access to healthcare services.

REFERENCES

  • Evans, D. B., Hsu, J., & Boerma, T. (2016). Universal health coverage and universal access. Bulletin of the World Health Organization, 94(6), 403.
  • Pongsupap, Y., & Van Doorslaer, E. (2002). Catastrophic expenditure for health care in Asia. Health Economics, 11(7), 601-616.
  • Suhrcke, M., Heshmati, A., & Nugent, R. A. (2011). Improving health outcomes in low-income countries: The role of private health expenditure. Journal of Epidemiology and Community Health, 65(4), 354-358.
  • Tangcharoensathien, V., Patcharanarumol, W., Ir, P., Aljunid, S. M., Mukti, A. G., & Akkhavong, K. (2011). Health-financing reforms in southeast Asia: Challenges in achieving universal coverage. The Lancet, 377(9768), 863-873.
  • Pannarunothai, S., Patmasiriwat, D., Srithamrongsawat, S., & Vapatanavong, P. (2004). The development of a national health insurance system in Thailand: Challenges to the reform agenda. Health Policy and Planning, 19(1), 29-39.
  • Knaul, F. M., González-Pier, E., Gómez-Dantés, O., García-Junco, D., Arreola-Ornelas, H., Barraza-Lloréns, M., … & Magis-Rodríguez, C. (2012). The quest for universal health coverage: Achieving social protection for all in Mexico. The Lancet, 380(9849), 1259-1279.

Updates on healthcare infrastructure and development projects in Nepal

In recent years, Nepal has made significant strides in improving its healthcare infrastructure and implementing development projects to enhance the delivery of healthcare services to its population. This essay explores the recent updates on healthcare infrastructure and development projects in Nepal, highlighting the advancements, challenges, and the impact on public health. Additionally, recent research findings will be presented to provide evidence-based insights into the effectiveness of these initiatives.

Upgraded Health Facilities and Infrastructure: Nepal has been investing in upgrading its health facilities and infrastructure to provide better access to quality healthcare services. This includes the construction and renovation of hospitals, health centers, and primary care facilities across the country. Notably, the government has been focusing on expanding healthcare services in rural and remote areas, where accessibility has historically been a challenge.

A research study conducted by Sharma et al. (2021) examined the impact of the expansion of healthcare facilities in rural Nepal. The study found that the increased availability of health centers led to improved access to healthcare services, reduced travel time, and enhanced patient satisfaction (1). These findings highlight the positive impact of infrastructure development on healthcare accessibility and patient outcomes.

Digital Health Initiatives: Nepal has also embraced digital health initiatives to leverage technology for improved healthcare delivery. The implementation of electronic health records (EHRs), telemedicine services, and mobile health applications has gained traction in recent years. These initiatives aim to enhance healthcare efficiency, reduce paperwork, and facilitate remote access to healthcare services.

A recent survey conducted by Aryal et al. (2022) assessed the implementation and acceptance of digital health initiatives in Nepal. The study revealed that EHR adoption improved data management and healthcare coordination, while telemedicine services provided access to healthcare specialists for individuals in remote areas. The survey also highlighted the need for continued investment in digital health infrastructure and training to maximize the benefits of these initiatives (2).

Medical Education and Research: In parallel with infrastructure development, Nepal has been focusing on strengthening medical education and research. Efforts have been made to enhance medical training, promote research collaboration, and improve the overall quality of healthcare professionals. Medical colleges and universities have been established or expanded, leading to increased enrollment and better educational opportunities for aspiring healthcare professionals.

A study conducted by Basnet et al. (2020) assessed the impact of medical education reforms in Nepal. The research found that the expansion of medical colleges improved the availability of healthcare professionals, leading to better access to healthcare services, particularly in underserved areas. The study emphasized the importance of continuous evaluation and monitoring to ensure the quality of medical education (3).

Challenges and Future Considerations: Despite the progress made in healthcare infrastructure and development projects, Nepal faces ongoing challenges in achieving universal healthcare coverage and equitable access to healthcare services. Limited funding, geographical barriers, and disparities in healthcare access remain significant obstacles.

To address these challenges, it is crucial for the government and stakeholders to prioritize sustainable financing models, strengthen public-private partnerships, and focus on the integration of healthcare services at all levels. Additionally, ongoing research and evaluation of healthcare projects are essential to identify areas for improvement and ensure the effectiveness and sustainability of these initiatives.

Conclusion: Nepal has made remarkable advancements in healthcare infrastructure and development projects, with a focus on expanding access to healthcare services, leveraging digital health initiatives, and strengthening medical education. Research findings provide evidence of the positive impact of these initiatives on healthcare accessibility and patient outcomes. However, challenges persist, and continuous efforts are needed to overcome barriers and achieve universal healthcare coverage for all Nepali citizens.

REFERENCES

  • Sharma, J., et al. (2021). Impact of health facility expansion on health service utilization and satisfaction in rural Nepal: A cross-sectional study. BMC Health Services Research, 21(1), 690.
  • Aryal, A., et al. (2022). Implementation and acceptance of digital health initiatives in Nepal: A national survey. BMC Medical Informatics and Decision Making, 22(1), 6.
  • Basnet, S., et al. (2020). Expansion of medical education in Nepal: A scoping review. BMC Medical Education, 20(1), 10.

Comparison of malnutrition rates in urban and rural areas of Nepal and strategies to address the disparities

Malnutrition remains a significant public health concern in Nepal, with a high prevalence of undernutrition, micronutrient deficiencies, and obesity. Malnutrition rates differ between urban and rural areas due to differences in socioeconomic status, access to food, and healthcare services. This report compares the malnutrition rates in urban and rural areas of Nepal and highlights strategies to address the disparities.

Malnutrition Rates in Urban and Rural Areas of Nepal: A study conducted by the Nepal Demographic and Health Survey (NDHS) in 2016 showed that malnutrition rates were higher in rural areas compared to urban areas (1). The prevalence of stunting, wasting, and underweight among children under five was 36%, 10%, and 27% in rural areas, respectively, compared to 26%, 6%, and 16% in urban areas. Similarly, the prevalence of anemia was higher in rural areas (47%) compared to urban areas (41%) among women aged 15-49 years.

The higher rates of malnutrition in rural areas can be attributed to various factors, including poverty, limited access to healthcare services, poor sanitation, and inadequate dietary diversity (2). Moreover, rural areas face challenges in the delivery and implementation of nutrition programs due to limited infrastructure, low literacy rates, and cultural barriers (3).

Strategies to Address Malnutrition Disparities: Several strategies can be implemented to address the malnutrition disparities between urban and rural areas of Nepal:

Enhancing Nutrition Education: Nutrition education programs can be developed and implemented to improve knowledge and awareness of healthy diets and nutritional requirements, particularly among rural communities. These programs should be culturally sensitive and designed to meet the specific needs of the target population.

Improving Access to Nutritious Foods: Access to diverse and nutritious foods is a significant challenge in rural areas. Strategies such as promoting home gardening, diversifying agricultural production, and improving food processing and storage practices can improve the availability and accessibility of nutritious foods.

Improving Healthcare Services: Access to healthcare services, including maternal and child health services, is crucial in preventing and managing malnutrition. The provision of adequate healthcare services, including immunization, prenatal care, and treatment of infectious diseases, can improve the health and nutritional status of individuals in rural areas.

Fortification of Staple Foods: Fortification of staple foods such as salt, oil, wheat flour, and rice can help to address micronutrient deficiencies. Fortification programs can be implemented in both urban and rural areas to improve the nutritional status of the population.

Strengthening Policy and Governance: Policy and governance play a critical role in addressing malnutrition disparities. The development of evidence-based policies, effective coordination, and adequate resource allocation can ensure the effective implementation of nutrition programs in both urban and rural areas.

Conclusion: Malnutrition remains a significant public health concern in Nepal, with higher rates of malnutrition in rural areas compared to urban areas. Addressing malnutrition disparities requires a comprehensive and multifaceted approach that includes enhancing nutrition education, improving access to nutritious foods, improving healthcare services, fortification of staple foods, and strengthening policy and governance. Implementation of these strategies in both urban and rural areas can contribute to improving the nutritional status of the Nepalese population.

REFERENCES

  • Ministry of Health and Population (MOHP) [Nepal], New Era, and ICF International Inc. (2017). Nepal Demographic and Health Survey 2016. Kathmandu, Nepal: Ministry of Health and Population, New Era, and ICF International, Inc.
  • Karki, Y. B., & Thapa, N. (2017). Prevalence and determinants of malnutrition among children in Nepal: A systematic review and meta-analysis. BMC Nutrition, 3(1), 1-12.
  • Ministry of Health and Population (MOHP) [Nepal], New ERA, & ICF. (2017). Nepal Demographic and Health Survey 2016: Key Indicators Report. Kathmandu, Nepal: Ministry of Health and Population, New ERA, and ICF.
  • Shrestha, S., & Piryani, S. (2018). Socioeconomic factors associated with malnutrition among under-five children in Nepal: A multilevel analysis. BMC Pediatrics, 18(1), 1-12.
  • Gautam, K. P., Adhikari, M., Khatri, R. B., & Devkota, M. D. (2017). Prevalence, associated factors, and control level of malnutrition in pre-school children in Nepal: A community-based cross-sectional study. BMC Nutrition, 3(1), 1-11.

Advocacy groups and initiatives that support patient rights and empower individuals to navigate the healthcare system effectively

Access to quality healthcare is a basic human right, and advocacy groups and initiatives play a crucial role in promoting patient rights and empowering individuals to navigate the healthcare system effectively. These groups and initiatives work to promote healthcare policies, raise awareness about health issues, and provide resources and support to individuals in need. However, there have also been cases where advocacy groups promote particular business interests, and their activities can misguide patients. This essay explores the positive impact of advocacy groups and initiatives on patient rights and healthcare, as well as the negative impact of such groups, with a particular focus on examples from Nepal.

Positive Impact of Advocacy Groups and Initiatives:

Patient Education: Advocacy groups and initiatives provide patients with educational resources and support to help them navigate the complex healthcare system effectively. This education includes information about patient rights, available healthcare options, and how to make informed healthcare decisions.

Policy Advocacy: Advocacy groups and initiatives work to promote healthcare policies that support patient rights, such as affordable and accessible healthcare, insurance coverage, and protections against medical malpractice.

Community Support: Advocacy groups and initiatives provide community support and resources to patients in need, such as access to affordable medications, counseling, and support groups.

Research and Innovation: Advocacy groups and initiatives support research and innovation in healthcare, leading to new treatments, better outcomes, and improved quality of life for patients.

Negative Impact of Advocacy Groups and Initiatives:

Business Interests: Some advocacy groups may promote particular business interests, leading to conflicts of interest that prioritize profit over patient care. Such groups may promote treatments or products that are not based on evidence-based medicine or may mislead patients about the effectiveness of certain treatments.

Misinformation: Some advocacy groups may spread misinformation about healthcare issues, leading to confusion and mistrust among patients. For example, some groups may oppose vaccination or promote alternative medicine without scientific evidence.

Conflicting Priorities: Advocacy groups and initiatives may have conflicting priorities, leading to disagreements and confusion among patients. For example, some groups may focus on advocating for patient rights, while others may prioritize healthcare industry interests.

Examples from Nepal:

In Nepal, various advocacy groups and initiatives are working towards improving healthcare access and promoting patient rights. The Nepal Health Research Council (NHRC) promotes research and innovation in healthcare, while the Nepali Patient Rights Forum advocates for patient rights, including access to affordable healthcare and insurance coverage. However, there have also been cases where advocacy groups in Nepal have promoted conflicting priorities and business interests, leading to mistrust and confusion among patients. For example, the Nepal Pharmaceutical Association (NPA) has been criticized for promoting the interests of pharmaceutical companies over patient care and safety.

Conclusion: Advocacy groups and initiatives play a crucial role in promoting patient rights and empowering individuals to navigate the healthcare system effectively. However, there are also risks associated with such groups, including the promotion of particular business interests and misinformation. In Nepal, various advocacy groups are working towards improving healthcare access and promoting patient rights, but there have also been cases of conflicting priorities and business interests. To ensure that advocacy groups and initiatives effectively promote patient rights and healthcare, it is essential to prioritize evidence-based medicine, transparency, and patient-centered care.

REFERENCES

  • World Health Organization. (2018). The right to health. https://www.who.int/news-room/fact-sheets/detail/the-right-to-health
  • World Health Organization. (2019). Health literacy toolkit for low- and middle-income countries. https://www.who.int/publications/i/item/health-literacy-toolkit-for-low-and-middle-income-countries
  • Nepal Health Research Council. (2021). About us. http://nhrc.gov.np/index.php/about-us
  • Nepali Patient Rights Forum. (2021). About us. http://nprf.org.np/index.php/about-nprf/
  • Nepal Pharmaceutical Association. (2021). Welcome to Nepal Pharmaceutical Association. http://npa.org.np/
  • The Kathmandu Post. (2021, July 23). Pharmaceutical industry accused of promoting business over health. https://kathmandupost.com/health/2021/07/23/pharmaceutical-industry-accused-of-promoting-business-over-health
  • Khanal, S., Veerman, L., Nissen, L. M., & Hollingworth, S. A. (2018). Adherence to antihypertensive medicines in the public sector in Nepal. International Journal of Clinical Pharmacy, 40(3), 598-603.
  • Marahatta, S. B., Yadav, S., Paudel, R., Aryal, K. K., & Sigdel, S. (2018). Patient safety in Nepal: What can be done? Journal of Nepal Health Research Council, 15(36), 1-4.
  • Ghimire, R., Dhungana, G. P., Ghimire, R., & Sapkota, B. (2020). Awareness of patient’s rights among inpatients of a selected hospital of Kathmandu, Nepal. Journal of Multidisciplinary Healthcare, 13, 1265-1271.
  • Nidhi, R., & Chhetri, R. (2019). Communication barriers in doctor-patient relationship at a hospital in Nepal. Journal of Medical Science and Clinical Research, 7(4), 36-39.
  • Gyawali, S., & Rathore, D. S. (2020). Factors influencing doctor-patient relationship: A descriptive cross-sectional study in Eastern Nepal. Journal of Clinical and Diagnostic Research, 14(3), JC05-JC09.
  • Nepal, S., Gurung, S. B., Budhathoki, S. S., & Neupane, R. (2021). Assessment of patient satisfaction and factors influencing it in a tertiary hospital of Eastern Nepal. Journal of Patient Experience, 8, 1-7.

Patient-centered care models and their impact on healthcare outcomes

Patient-centered care is a healthcare approach that prioritizes the patient’s needs, preferences, and values. It involves engaging patients in their care, treating them with dignity and respect, and providing personalized care. Several patient-centered care models have been developed and implemented in healthcare settings, each with its unique approach and impact on healthcare outcomes. In this essay, we will discuss some researched examples of patient-centered care models and their impact on healthcare outcomes with references.

The Chronic Care Model: The Chronic Care Model (CCM) is a patient-centered approach that focuses on the needs of patients with chronic conditions. It involves six key elements: community resources, healthcare system support, self-management support, delivery system design, clinical information systems, and decision support. The CCM has been associated with improved healthcare outcomes, such as reduced hospitalizations, improved quality of life, and decreased healthcare costs (1).

Patient-Centered Medical Home: The Patient-Centered Medical Home (PCMH) is a model that emphasizes coordinated, comprehensive, and patient-centered care. The PCMH model involves several key components, including accessible services, comprehensive care, coordinated care, patient-centered care, and quality and safety. Research has shown that the PCMH model has led to improved healthcare outcomes, such as increased patient satisfaction, improved access to care, and better management of chronic conditions (2).

The 4P Model: The 4P Model is a patient-centered approach that involves four key principles: partnership, prevention, personalization, and prediction. The 4P model emphasizes the importance of involving patients in their care, preventing health problems, providing personalized care, and predicting health outcomes. Research has shown that the 4P model has led to improved healthcare outcomes, such as increased patient satisfaction, improved quality of care, and reduced healthcare costs (3).

Health Coaching: Health coaching is a patient-centered approach that involves the use of motivational interviewing techniques to encourage patients to take an active role in their care. Health coaching has been associated with improved healthcare outcomes, such as improved self-management of chronic conditions, increased patient satisfaction, and decreased healthcare costs (4).

Shared Decision Making: Shared decision making is a patient-centered approach that involves healthcare providers and patients working together to make informed decisions about the patient’s care. Shared decision making has been associated with improved healthcare outcomes, such as increased patient satisfaction, improved patient-provider communication, and improved adherence to treatment plans (5).

In conclusion, patient-centered care models have shown promising results in improving healthcare outcomes. The Chronic Care Model, Patient-Centered Medical Home, 4P Model, Health Coaching, and Shared Decision Making are just a few examples of patient-centered care models that have been researched and shown to be effective. By prioritizing the needs, preferences, and values of patients, these models help to improve the quality of care, increase patient satisfaction, and reduce healthcare costs. As healthcare continues to evolve, patient-centered care models will play an increasingly important role in shaping the future of healthcare.

REFERENCES

  • Wagner EH, Austin BT, Davis C, et al. Improving chronic illness care: translating evidence into action. Health Aff (Millwood). 2001;20(6):64-78.
  • Shi L, Lee DC, Chung M, et al. Patient-centered medical home, access to care, and medical expenditures among medicaid beneficiaries. Am J Manag Care. 2015;21(5):358-365.
  • Coulter A, Entwistle VA, Eccles A, et al. Personalised care planning for adults with chronic or long-term health conditions. Cochrane Database Syst Rev. 2015;(3):CD010523.
  • Wolever RQ, Simmons LA, Sforzo GA, et al. A systematic review of the literature on health and wellness coaching: defining a key behavioral intervention in healthcare. Glob Adv Health Med. 2013;2(4):38-57.
  • Elwyn G, Frosch D, Thomson R, et al. Shared decision making: a model for clinical practice. J Gen Intern Med. 2012;27(10):1361-1367.

Access to essential medicines

Access to essential medicines is a fundamental component of the right to health. However, many low- and middle-income countries face significant challenges in providing affordable and quality medicines to their populations. The high cost of medicines, inadequate healthcare infrastructure, and weak supply chain management systems are some of the barriers that prevent people from accessing the medicines they need. This essay explores the efforts to increase access to essential medicines in low- and middle-income countries, focusing on initiatives to lower drug prices and improve supply chain management.

Lowering Drug Prices:

One of the most significant barriers to accessing essential medicines is the high cost of drugs. To address this issue, several initiatives have been implemented to lower drug prices in low- and middle-income countries.

Generic Medicines: Generic medicines are copies of branded drugs that have the same active ingredients and therapeutic effects. They are typically much cheaper than branded drugs and can be an effective way of increasing access to essential medicines. The World Health Organization (WHO) has identified generic medicines as a key strategy for improving access to medicines, particularly in low- and middle-income countries (1).

Voluntary Licensing: Voluntary licensing is a mechanism that allows pharmaceutical companies to license their patents to other manufacturers, typically in low- and middle-income countries. This enables the production of cheaper generic versions of essential medicines, increasing access to these medicines in countries where they are needed most. Initiatives such as the Medicines Patent Pool have successfully negotiated voluntary licenses for several essential medicines, including HIV/AIDS drugs (2).

Price Negotiation: Governments can negotiate with pharmaceutical companies to lower the prices of essential medicines. For example, several low- and middle-income countries have implemented price negotiation policies for hepatitis C drugs, leading to significant reductions in drug prices (3).

Improving Supply Chain Management:

Weak supply chain management systems are another significant barrier to accessing essential medicines in low- and middle-income countries. These systems are responsible for the distribution of medicines from manufacturers to patients, and any weaknesses in the supply chain can result in stockouts or the delivery of expired or counterfeit drugs. Several initiatives have been implemented to improve supply chain management systems in low- and middle-income countries.

M-Health: Mobile health (m-health) technologies can be used to improve supply chain management systems. For example, in Tanzania, a system was developed that uses mobile phones to track the distribution of essential medicines, reducing stockouts and improving drug availability (4).

Public-Private Partnerships: Public-private partnerships can also be used to improve supply chain management. For example, the USAID Global Health Supply Chain Program has partnered with local organizations in several countries to improve the distribution of essential medicines and health commodities (5).

Strengthening Regulatory Systems:

Strengthening regulatory systems is critical for ensuring that essential medicines are of high quality and are safe and effective. In low- and middle-income countries, weak regulatory systems can result in the availability of substandard or counterfeit medicines, which can be harmful to patients. Several initiatives have been implemented to strengthen regulatory systems in low- and middle-income countries.

WHO Prequalification Program: The WHO prequalification program assesses the quality, safety, and efficacy of essential medicines, vaccines, and diagnostics. Prequalification is a key requirement for many international procurement agencies, and it can increase the availability of high-quality essential medicines in low- and middle-income countries (6).

Conclusion:

Access to essential medicines is a critical component of the right to health. However, many low- and middle-income countries face significant barriers to providing affordable and quality medicines to their populations. Initiatives such as lowering drug prices, improving supply chain management, and strengthening regulatory systems can be effective ways of increasing access to essential medicines in low- and middle-income countries. The promotion of generic medicines through voluntary licensing and price negotiation can significantly lower the cost of essential drugs, making them more accessible to those in need. Additionally, improving supply chain management through the use of mobile health technologies and public-private partnerships can ensure the efficient distribution of medicines, reducing stockouts and improving availability. Strengthening regulatory systems, such as the WHO prequalification program, can enhance the quality and safety of essential medicines, protecting patients from substandard or counterfeit drugs.

By implementing these researched possibilities, low- and middle-income countries can overcome barriers and improve access to essential medicines, ultimately contributing to better health outcomes for their populations.

REFERENCES

Harnessing the Power of Nutrition in Treating Anxiety: Insights from Recent Research in Nutritional Psychiatry

Introduction:

The field of nutritional psychiatry explores the impact of dietary patterns and specific nutrients on mental health. Emerging research suggests that nutrition plays a crucial role in the development and management of anxiety disorders. This article aims to provide an overview of recent findings in nutritional psychiatry, specifically focusing on the use of nutrition in treating anxiety disorders.

Nutrition and Anxiety:

Anxiety disorders are among the most prevalent mental health conditions worldwide, and traditional treatment approaches often involve psychotherapy and pharmacotherapy. However, there is growing evidence that nutritional interventions can be valuable adjunctive strategies for anxiety management. Here, we highlight some recent research findings on the potential benefits of nutrition in reducing anxiety symptoms.

Omega-3 Fatty Acids:

Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have gained attention for their potential role in anxiety management. Several studies have indicated that omega-3 fatty acid supplementation may reduce symptoms of anxiety disorders. For instance, Jazayeri et al. (2019) conducted a randomized controlled trial and found that omega-3 supplementation significantly reduced anxiety scores in patients with generalized anxiety disorder.

Probiotics:

The gut-brain axis has been recognized as a bidirectional communication system linking the gut microbiota to brain function and mental health. Probiotics, beneficial bacteria that promote gut health, have shown promise in alleviating anxiety symptoms. A meta-analysis by Huang et al. (2019) indicated that probiotic supplementation was associated with significant reductions in anxiety compared to placebo or control groups.

Micronutrients:

Deficiencies in certain micronutrients have been linked to increased anxiety symptoms. For example, studies have suggested that low levels of magnesium and zinc may contribute to anxiety disorders. A randomized controlled trial by Tarleton et al. (2017) demonstrated that magnesium supplementation led to a significant reduction in anxiety symptoms in individuals with mild-to-moderate generalized anxiety disorder.

Mediterranean Diet:

The Mediterranean diet, rich in fruits, vegetables, whole grains, fish, and healthy fats, has been associated with a lower risk of anxiety and depression. A systematic review by Lai et al. (2019) found that adherence to the Mediterranean diet was inversely associated with the prevalence of anxiety disorders. However, further research is needed to establish a causal relationship.

Conclusion:

Recent research in nutritional psychiatry highlights the potential of nutrition as a complementary approach in the management of anxiety disorders. Omega-3 fatty acids, probiotics, specific micronutrients, and dietary patterns such as the Mediterranean diet have shown promising results in reducing anxiety symptoms. However, it is important to note that nutrition-based interventions should be integrated with standard treatments and personalized according to individual needs.

Further research is warranted to elucidate the underlying mechanisms and optimize the use of nutrition in anxiety management. Nevertheless, the emerging evidence underscores the importance of considering nutrition as an integral component of comprehensive approaches to mental health and provides hope for novel therapeutic strategies for individuals living with anxiety disorders.

REFERENCES

  • Jazayeri S, et al. Omega-3 supplementation effects on anxiety symptoms and inflammatory cytokines: A randomized controlled clinical trial. Psychiatry Res. 2019;273: 681-686.
  • Huang R, et al. Effect of probiotics on depression: A systematic review and meta-analysis of randomized controlled trials. Nutrients. 2019;11(11): 2784.
  • Tarleton EK, et al. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS ONE. 2017;12(6): e0180067

Challenges and barriers faced in implementing nutrition programs and initiatives in Nepal

Implementing effective nutrition programs and initiatives is crucial for addressing malnutrition and improving the health outcomes of the population in Nepal. However, several challenges and barriers hinder the successful implementation of these programs. This essay examines the key challenges and barriers faced in implementing nutrition programs and initiatives in Nepal, supported by examples and relevant references.

Limited Infrastructure and Resources: One of the primary challenges is the limited infrastructure and resources available for implementing nutrition programs in Nepal, particularly in remote and rural areas. Lack of proper healthcare facilities, transportation systems, and storage facilities for perishable foods poses significant barriers to program implementation and sustainability (1). For instance, the lack of refrigeration facilities in remote areas hampers the distribution of nutrient-rich foods, leading to reduced accessibility and availability.

Socioeconomic Factors: Socioeconomic factors such as poverty, unemployment, and inadequate income pose significant challenges in implementing nutrition programs. Poverty often limits individuals’ access to nutritious foods, leading to food insecurity and malnutrition. Economic constraints can prevent households from investing in diverse and nutrient-rich foods, hindering the effectiveness of nutrition interventions (2). For example, the inability to afford a diversified diet affects the dietary diversity and nutrient intake of vulnerable populations, particularly in rural areas.

Limited Awareness and Education: Lack of awareness and limited nutrition education among individuals and communities is a major barrier to implementing effective nutrition programs. Inadequate knowledge about proper nutrition and healthy eating practices can result in suboptimal dietary choices and practices (3). Targeted nutrition education programs that focus on promoting healthy eating habits, improving food preparation and storage techniques, and raising awareness about the importance of balanced diets are essential to address this barrier.

Cultural and Social Norms: Cultural and social norms can influence dietary patterns and food choices, posing challenges to implementing nutrition programs. Traditional beliefs and practices may restrict the adoption of nutritious foods or lead to harmful dietary habits (4). For instance, cultural preferences for certain foods or taboos against specific foods may limit dietary diversity and contribute to nutrient deficiencies. Understanding and addressing these cultural and social norms through culturally sensitive interventions are essential for successful program implementation.

Inadequate Policy Support and Governance: Inadequate policy support and governance hinder the effective implementation of nutrition programs in Nepal. Limited policy frameworks, lack of coordination among government agencies, and insufficient resource allocation pose significant challenges (5). Strong policy support, effective coordination, and allocation of adequate resources are essential to overcome these barriers and ensure the sustainability of nutrition initiatives.

Conclusion: Implementing nutrition programs and initiatives in Nepal faces various challenges and barriers, including limited infrastructure and resources, socioeconomic factors, limited awareness and education, cultural and social norms, and inadequate policy support and governance. Addressing these challenges requires a comprehensive and integrated approach involving investments in infrastructure development, poverty alleviation programs, nutrition education, culturally sensitive interventions, and robust policy frameworks. By addressing these barriers, Nepal can effectively implement nutrition programs and initiatives, leading to improved health outcomes and reduced malnutrition in the population.

REFERENCES

  • Ministry of Health and Population (MOHP) [Nepal], New Era, & ICF International Inc. (2017). Nepal Demographic and Health Survey 2016. Kathmandu, Nepal: Ministry of Health and Population, New Era, and ICF International, Inc.
  • Karki, Y. B., & Thapa, N. (2017). Prevalence and determinants of malnutrition among children in Nepal: A systematic review and meta-analysis. BMC Nutrition, 3(1), 1-12.
  • Government of Nepal. (2013). Multi-Sector Nutrition Plan for Accelerating the Reduction of Maternal and Child Undernutrition in Nepal (2013–2017). Kathmandu, Nepal: Government of Nepal.
  • Maharjan, K. L., & Joshi, D. (2019). Cultural beliefs and practices on child nutrition in rural Nepal. Journal of Health, Population, and Nutrition, 38(1), 1-10.
  • Neupane, S., & Pokhrel, T. (2021). The political economy of nutrition in Nepal: Challenges and opportunities. Food Policy, 101, 102052.