Defective Sperm and Pregnancy Complications: Understanding the Connection and Its Impact

Written By THT Editorial Team

Reviewed by Dr. Asmita Pandey, Fertility Expert, M.D. (OB/GYN)
Infertility and pregnancy complications are major concerns for couples trying to conceive, with male infertility playing just as important a role as female factors. Recent studies have shown that defective sperm can significantly affect pregnancy outcomes, highlighting the need to address male fertility as part of overall reproductive health. This essay examines the role of defective sperm, its connection to pregnancy complications, and what this means for reproductive health.
What Determines Sperm Quality?
Sperm quality is a key factor in male fertility. It includes factors like sperm count, movement (motility), shape (morphology), and, most importantly, the integrity of the sperm’s DNA. Research shows that DNA integrity is crucial for successful fertilization and healthy embryo development (Panner Selvam et al., 2020). When sperm DNA is damaged—such as having breaks or other issues—it can lead to problems like miscarriages or developmental issues in the embryo (Alvarez et al., 2023).
Recent Research on Defective Sperm
A study in Human Reproduction found that sperm with frequent DNA damage is linked to higher risks of pregnancy complications, including miscarriage, preterm birth, and low birth weight (Willerslev, 2023). These findings remained consistent even after accounting for factors like the mother’s age and lifestyle, suggesting that sperm quality is an independent factor in pregnancy success. The study analyzed sperm samples from men whose partners had pregnancy complications and found that higher levels of sperm DNA damage were associated with worse pregnancy outcomes (Zini et al., 2008).
How Defective Sperm Leads to Pregnancy Complications
The ways in which defective sperm causes pregnancy complications are complex. Damaged sperm DNA can lead to chromosomal abnormalities in the embryo, problems with placental function, and poor fetal growth (Zheng et al., 2018). When an egg is fertilized by sperm with damaged DNA, the embryo may develop genetic issues, which can disrupt normal growth and lead to complications. Additionally, defective sperm can cause inflammation in the female reproductive tract, which may interfere with implantation and proper placental development (Bernal et al., 2019). This inflammation can contribute to conditions like preeclampsia and restricted fetal growth (Musson et al., 2022).
What This Means for Reproductive Health
The link between defective sperm and pregnancy complications has important implications for reproductive healthcare, especially in infertility treatments and assisted reproductive technologies (ART) Advanced tests, like the sperm chromatin structure assay (SCSA) and the TUNEL assay, can now measure sperm DNA damage more accurately (Dutta et al., 2020). These tools help doctors assess male fertility beyond traditional measures like sperm count and motility.
Improved Treatments: Addressing sperm DNA damage may involve lifestyle changes, antioxidant therapy, or medical treatments. Antioxidants like vitamins C and E, coenzyme Q10, and selenium can help reduce oxidative stress and improve sperm DNA quality (Romano et al., 2024).
Assisted Reproductive Technologies (ART): For couples using ART, selecting sperm with intact DNA can improve the chances of a successful pregnancy. Techniques like intracytoplasmic sperm injection (ICSI) combined with DNA testing can help identify the healthiest sperm for fertilization (Esteves et al., 2021).
Prevention: Educating men about factors that harm sperm DNA—such as smoking, excessive drinking, and exposure to environmental toxins—can encourage healthier habits and reduce the risk of defective sperm (Leslie, Soon-Sutton, & Khan, 2024).
Conclusion
The connection between defective sperm and pregnancy complications emphasizes the importance of evaluating and treating male fertility as part of reproductive healthcare. By focusing on sperm DNA integrity, doctors can improve pregnancy outcomes, offering hope to couples struggling with infertility and reducing the risk of complications. Ongoing research will continue to enhance our understanding of male infertility, leading to more personalized treatments and better support for families worldwide.
For further information about reproductive health, please book your consultation with fertility expert here.
REFERENCES
- Panner Selvam, M. K., Sengupta, P., & Agarwal, A. (2020). Sperm DNA fragmentation and male infertility. In M. Arafa, H. Elbardisi, A. Majzoub, & A. Agarwal (Eds.), Genetics of male infertility (pp. 195-207). Springer. https://doi.org/10.1007/978-3-030-37972-8_9B
- Alvarez, J.G., García-Peiró, A., Barros, A. et al. Double strand DNA breaks in sperm: the bad guy in the crowd. J Assist Reprod Genet 40, 745–751 (2023). https://doi.org/10.1007/s10815-023-02748-5
- Willerslev, E. (2023). Influence of diet and exercise on sperm and its epigenome. Human Reproduction, 38(Suppl. 1), dead093.001. https://doi.org/10.1093/humrep/dead093.001
- Zini, A., Boman, J. M., Belzile, E., & Ciampi, A. (2008). Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis. Human Reproduction, 23(12), 2663–2668. https://doi.org/10.1093/humrep/den321
- Zheng WW, Song G, Wang QL, Liu SW, Zhu XL, Deng SM, Zhong A, Tan YM, Tan Y. Sperm DNA damage has a negative effect on early embryonic development following in vitro fertilization. Asian J Androl. 2018 Jan-Feb;20(1):75-79. doi: 10.4103/aja.aja_19_17. PMID: 28675153; PMCID: PMC5753558.
- Musson R, Gąsior Ł, Bisogno S, Ptak GE. DNA damage in preimplantation embryos and gametes: specification, clinical relevance and repair strategies. Hum Reprod Update. 2022 May 2;28(3):376-399. doi: 10.1093/humupd/dmab046. PMID: 35021196; PMCID: PMC9071077.
- Dutta, S., Henkel, R., & Agarwal, A. (2020). Comparative analysis of tests used to assess sperm chromatin integrity and DNA fragmentation. Andrologia. https://doi.org/10.1111/and.13718
- Romano, M., Cirillo, F., Spadaro, D., Busnelli, A., Castellano, S., Albani, E., & Levi-Setti, P. E. (2024). High sperm DNA fragmentation: do we have robust evidence to support antioxidants and testicular sperm extraction to improve fertility outcomes? A narrative review. Human Reproduction Update
- Esteves SC, Zini A, Coward RM, Evenson DP, Gosálvez J, Lewis SEM, Sharma R, Humaidan P. Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations. Andrologia. 2021 Mar;53(2):e13874. doi: 10.1111/and.13874. Epub 2020 Oct 27. PMID: 33108829; PMCID: PMC7988559.
- Leslie, S. W., Soon-Sutton, T. L., & Khan, M. A. B. (2024). Male infertility. In Author Information and Affiliations. Last update: February 25, 2024. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK562258/