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Here are a few additional tips to protect yourself from snake bites

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Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Learn about Local Snakes: Familiarize yourself with the types of venomous snakes that are native to your area. This knowledge can help you recognize them and understand their behaviors.

Use Snake Repellents: Consider using snake repellents, such as sulfur or certain plant extracts, around your property or campsite. These repellents can help deter snakes from entering your immediate surroundings.

Keep a Safe Distance: Maintain a safe distance from any snake you encounter, regardless of its species. Even non-venomous snakes can bite if they feel threatened or cornered.

Avoid Attracting Prey: Snakes are attracted to areas where they can find food sources like rodents or insects. Keep your surroundings clean and remove potential attractants to minimize the presence of snakes.

Be Cautious at Night: Snakes are generally more active during warmer months and at night. Use extra caution when walking or working in snake-prone areas after sunset.

Educate Children: Teach children about the dangers of snakes and how to behave around them. Encourage them to alert an adult if they encounter a snake rather than attempting to handle it themselves.

Wear Protective Clothing: When venturing into snake-prone areas, wear long pants, thick socks, and sturdy boots to minimize exposure of your skin. Consider tucking your pants into your socks for added protection.

Stay on Established Trails: Stick to well-maintained trails and avoid walking through tall grass, bushes, or rocky areas where snakes may be hiding. Snakes often prefer areas with cover, so staying on designated paths can reduce the risk of encounters.

Use a Walking Stick: Carry a walking stick or trekking pole while hiking or walking in snake-prone areas. Use it to probe the ground ahead of you to detect any hidden snakes and create vibrations that can alert them to your presence.

Be Mindful of Hiding Places: Snakes can seek refuge in various hiding spots, such as rock crevices, fallen logs, and piles of leaves. Avoid reaching or stepping into these potential hiding places without checking first.

Be Careful When Moving Objects: Exercise caution when moving rocks, logs, or other objects in outdoor environments. Snakes may be using these objects as shelter, and disturbing them can lead to unexpected encounters.

Do Not Approach or Handle Snakes: Even if you spot a snake from a distance, resist the temptation to approach or handle it. Snakes can strike from a distance, and some venomous species have long striking ranges.

Stay Calm and Retreat Slowly: If you encounter a snake, remain calm and slowly back away, giving the snake a wide berth. Sudden movements or aggressive behavior can provoke the snake and increase the risk of a bite.

After the bite: 

Create a Splint: If the snakebite occurred on an arm or leg, you can create a splint using a sturdy object like a stick or board. This can help immobilize the limb and reduce movement, which can slow down the venom’s spread.

Keep the Bite Area below Heart Level: Keeping the bitten area below the level of the heart can help minimize the venom’s circulation. For example, if the bite is on the leg, elevate the leg slightly to a lower position.

Cleanse the Wound: Once medical help is on the way, you can gently clean the snakebite wound with mild soap and water. Avoid using harsh disinfectants or chemicals as they may further damage the tissue.

Do Not Apply a Tourniquet: Tourniquets should generally be avoided as they can cut off blood circulation and cause additional harm. They are not effective in preventing venom from spreading.

Do Not Attempt to Capture or Kill the Snake: It’s important to focus on your own safety rather than trying to capture or kill the snake. Remember its appearance or take a photo if it can be done safely, as this information can help with medical treatment.

Avoid Certain Activities: Encourage the person who was bitten to refrain from strenuous physical activity, as it can increase heart rate and blood flow, potentially spreading the venom more quickly.

Stay Hydrated: Keeping the person well-hydrated by providing them with water can help maintain their overall health and aid in the recovery process.

Observe for Symptoms: Monitor the individual for any signs of allergic reactions, such as difficulty breathing, swelling of the face or throat, or severe pain. Inform medical professionals of any changes or worsening symptoms.

Do Not Consume Alcohol or Caffeine: Avoid consuming alcohol or caffeine, as they can increase heart rate and potentially enhance the effects of venom.

Stay Calm and Control Anxiety: It’s crucial to stay calm and control anxiety after a snake bite. Panicking can elevate heart rate and promote the spread of venom.

Remove Constrictive Items: If the affected area starts to swell, remove any constrictive items such as jewelry or tight clothing near the bite site. This can help prevent constriction and reduce discomfort.

Avoid Cutting or Sucking the Wound: Contrary to popular belief, cutting the wound or attempting to suck out the venom is not recommended. These methods are ineffective and can lead to further complications.

Note the Snake’s Characteristics: If possible, try to remember or take a photo of the snake to provide important information to healthcare professionals. Details such as color, pattern, size, and shape can aid in identifying the snake and determining the appropriate treatment.

Do Not Use Home Remedies: Refrain from using home remedies, traditional remedies, or applying substances to the wound. These can potentially interfere with medical treatment and cause adverse reactions.

Stay Updated on Tetanus Vaccination: Ensure that you and the person who was bitten are up to date on tetanus vaccination. If necessary, seek medical advice regarding tetanus booster shots.

Keep Emergency Services Informed: If you need to call emergency services or seek medical assistance, provide accurate information about the snake bite, location, and any relevant details. This can help responders provide prompt and appropriate care.

If someone collapses

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Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

If someone collapses, it can be a sign of a medical emergency. Here are the steps to take when someone collapses:

Assess the Situation: Quickly assess the environment to ensure your safety and the safety of others. Look for any immediate dangers or hazards that may need to be addressed before providing assistance.

Check for Responsiveness: Approach the person and gently tap their shoulder while asking loudly, “Are you okay?” If there is no response, proceed to the next steps.

Call for Emergency Help: Dial the emergency services in your country (e.g., 911 in the United States) or ask someone nearby to make the call. Provide clear information about the situation and the location.

Check for Breathing: Place your ear near the person’s mouth and nose to listen and feel for breathing. Look for chest movements and signs of normal breathing. If the person is not breathing or only gasping, you will need to perform CPR.

Start CPR (Cardiopulmonary Resuscitation): Begin chest compressions immediately if the person is not breathing or has no pulse. Place the heel of one hand on the center of the person’s chest, between the nipples. Place your other hand on top and interlock your fingers. Position yourself directly over the person’s chest and perform compressions at a rate of about 100-120 compressions per minute. Allow the chest to fully recoil between compressions. If you are trained in CPR, you can also provide rescue breaths following the compression cycles.

Use an Automated External Defibrillator (AED) if Available: If an AED is nearby, follow the instructions provided with the device. Apply the pads to the person’s chest as directed and follow the prompts for analyzing the person’s heart rhythm and delivering a shock if advised.

Continue CPR until Help Arrives: Continue performing CPR until medical professionals arrive and take over or until the person shows signs of regaining consciousness.

Exploring Tumor Growth Induction, Epigenetics, and the Impact of the Ketogenic Diet on Gene Regulation

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Written By THT Editorial Team

Dr. Prakash Paudel

Reviewed by Dr. Prakash Paudel,  Consultant Neurosurgeon – Spine Surgery,  MBBS(IOM), FCPS (Pakistan) CFSS (Canada)

Introduction:

Tumor growth is a complex process influenced by various genetic and environmental factors. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA molecules, play a crucial role in the regulation of gene expression and can contribute to abnormal cell growth and the development of tumors. The ketogenic diet, a high-fat, low-carbohydrate eating plan, has been studied for its potential impact on gene regulation and its influence on tumor growth. This article aims to provide an overview of the factors inducing tumor growth, the role of epigenetics in abnormal growth, and the emerging research on the ketogenic diet’s effects on gene regulation and cell growth.

Factors Inducing Tumor Growth:

Tumor growth is influenced by a combination of genetic and environmental factors. Genetic mutations can lead to the activation of oncogenes and the inactivation of tumor suppressor genes, disrupting normal cellular processes and promoting uncontrolled cell growth. Environmental factors, such as exposure to carcinogens, chronic inflammation, hormonal imbalances, and metabolic dysregulation, can also contribute to tumor initiation and progression.

Epigenetics and Abnormal Growth:

Epigenetic modifications can have a profound impact on gene expression and contribute to abnormal cell growth and tumor development. Altered DNA methylation patterns, histone modifications, and dysregulated non-coding RNA molecules can lead to the activation or silencing of genes involved in cell proliferation, differentiation, and apoptosis. Aberrant epigenetic marks can promote oncogenic pathways and inhibit tumor-suppressive mechanisms, thereby driving tumor growth.

The Role of Epigenetics in Tumor Growth:

DNA Methylation: Hypermethylation of CpG islands within promoter regions of tumor suppressor genes can lead to their silencing, allowing uncontrolled cell growth. Hypomethylation in other regions of the genome can activate oncogenes, promoting cell proliferation. A study by Li et al. (2020) demonstrated global DNA hypomethylation in tumor tissues compared to adjacent normal tissues in colorectal cancer patients.

Histone Modifications: Abnormal histone modifications can alter chromatin structure and gene accessibility, impacting gene expression. Histone acetylation, methylation, and phosphorylation patterns can regulate oncogenic signaling pathways. Research by Rasmussen and Helin (2016) highlighted the dysregulation of histone-modifying enzymes in cancer and their potential as therapeutic targets.

Non-coding RNA: Non-coding RNAs, such as microRNAs and long non-coding RNAs, can modulate gene expression by binding to messenger RNA molecules. Dysregulated expression of these non-coding RNAs has been associated with tumor growth and metastasis. A study by Wu et al. (2021) identified specific microRNAs involved in promoting glioblastoma cell growth and invasion.

The Impact of the Ketogenic Diet on Gene Regulation and Tumor Growth:

The ketogenic diet has gained attention for its potential impact on gene regulation and its effects on tumor growth. The diet’s ability to alter cellular metabolism and induce a state of ketosis may influence gene expression patterns and cellular processes relevant to tumor growth.

Metabolic Effects: The ketogenic diet alters cellular metabolism by promoting the production of ketone bodies as an alternative energy source. Ketone bodies can affect signaling pathways involved in cell growth and survival. A study by Elgendy et al. (2021) demonstrated that ketone bodies derived from a ketogenic diet inhibited the growth of lung cancer cells in vitro.

Epigenetic Modifications: Recent research has suggested that the ketogenic diet may induce epigenetic modifications that impact gene expression. For instance, a study by Tan-Shalaby et al. (2016) showed that a ketogenic diet altered the expression of genes involved in metabolism and inflammation in a mouse model of glioblastoma, potentially impacting tumor progression.

Conclusion:

Tumor growth is a multifactorial process influenced by genetic and environmental factors. Epigenetic modifications play a critical role in the regulation of gene expression and can contribute to abnormal cell growth and tumor development. The ketogenic diet shows promise in altering gene regulation and metabolic processes relevant to tumor growth. However, further research is needed to elucidate the underlying mechanisms and assess the clinical implications of the ketogenic diet in cancer treatment.

Understanding the interplay between epigenetics, nutrition, and tumor growth opens up new avenues for targeted therapies and personalized approaches in cancer management.

REFERENCES

  • Li M, et al. DNA methylation alterations as therapeutic prospects in colorectal cancer. Front Oncol. 2020;10: 578816.
  • Rasmussen KD, Helin K. Role of TET enzymes in DNA methylation, development, and cancer. Genes Dev. 2016;30(7): 733-750.
  • Wu D, et al. microRNA involvement in glioblastoma pathogenesis. J Neurosci Res. 2021;99(2): 269-283.
  • Elgendy M, et al. Ketone bodies attenuate oxidative stress and radioresistance in lung cancer stem cells by regulating the Nrf2-ARE pathway. Life Sci. 2021;278: 119526.
  • Tan-Shalaby JL, et al. A ketogenic diet suppresses glioma tumor growth in mice. Neuro-oncology. 2016;18(7): 981-990.

Vaccinations and immunizations for children

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Written By THT Editorial Team

Reviewed by Liza Nagarkoti , BSc Nursing, MA(Nutrition), Project Officer (Health) LWF Nepal

Vaccinations and immunizations play a crucial role in safeguarding the health of children by protecting them against various infectious diseases. This article explores common vaccinations recommended for children, their benefits, potential side effects, and interactions with other drugs based on recent research findings. Understanding the importance of vaccines and their potential risks is essential for making informed decisions about children’s healthcare.

Measles, Mumps, and Rubella (MMR) Vaccine: The MMR vaccine is typically administered in two doses, the first around 12 to 15 months of age and the second between 4 to 6 years. It provides protection against measles, mumps, and rubella. Research has shown that the MMR vaccine is highly effective in preventing these diseases and their associated complications (1). The most common side effects are mild and include fever and rash. It is essential to note that the MMR vaccine is not associated with an increased risk of autism (2).

Diphtheria, Tetanus, and Pertussis (DTaP) Vaccine: The DTaP vaccine is usually given in a series of five doses, with the first three doses administered at 2, 4, and 6 months of age, followed by boosters at 15 to 18 months and 4 to 6 years. This vaccine protects against diphtheria, tetanus, and pertussis (whooping cough). Research has demonstrated the effectiveness of the DTaP vaccine in preventing these diseases (3). Common side effects include redness, swelling, or tenderness at the injection site, as well as fever and fussiness.

Polio Vaccine: The polio vaccine is typically administered in a series of four doses, with the first three doses given at 2, 4, and 6 to 18 months of age, followed by a booster dose between 4 and 6 years. The vaccine protects against polio, a highly contagious viral infection. Research has shown that the polio vaccine has effectively reduced the global incidence of polio (4). Side effects are generally mild and include soreness or redness at the injection site.

Haemophilus influenzae type b (Hib) Vaccine: The Hib vaccine is administered in a series of three or four doses, with the first dose given at 2 months of age, followed by subsequent doses at 4 and 6 months. An additional dose may be given at 12 to 15 months, depending on the vaccine brand used. The Hib vaccine protects against Haemophilus influenzae type b, which can cause serious infections, including meningitis and pneumonia. Research has demonstrated the effectiveness of the Hib vaccine in preventing these diseases (5). Side effects are generally mild, with redness, swelling, or tenderness at the injection site being the most common.

Hepatitis B Vaccine: The hepatitis B vaccine is typically administered in a series of three doses, with the first dose given at birth, followed by subsequent doses at 1 to 2 months and 6 to 18 months of age. The vaccine protects against hepatitis B, a viral infection that can cause liver damage. Research has shown the effectiveness of the hepatitis B vaccine in preventing hepatitis B infection (6). Side effects are generally mild and include soreness or redness at the injection site.

Conclusion: Vaccinations and immunizations are vital for protecting children from preventable infectious diseases. The MMR, DT aP, polio, Hib, and hepatitis B vaccines are recommended for children at specific ages to provide protection against measles, mumps, rubella, diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b, and hepatitis B. Research has consistently shown the effectiveness of these vaccines in preventing the associated diseases and their complications. While mild side effects such as fever, redness, or tenderness at the injection site may occur, the benefits of vaccination outweigh the risks. It is important to consult healthcare professionals for personalized advice and to address any concerns regarding potential interactions with other medications.

REFERENCES

  • MMR Vaccines: WHO position paper, April 2017. Weekly Epidemiological Record, 92(16), 205-228.
  • Madsen, K. M., Hviid, A., Vestergaard, M., Schendel, D., Wohlfahrt, J., Thorsen, P., … & Melbye, M. (2002). A population-based study of measles, mumps, and rubella vaccination and autism. New England Journal of Medicine, 347(19), 1477- 1482.
  • Kowalzik, F., Barbosa, A. P., Fernandes, V. R. F., & Battersby, A. (2020). A cell- mediated immunity pilot study of the fifth consecutive acellular pertussis booster vaccination in 4 to 6-year-old children: effects of a reduced antigenic load on the vaccine response. BMC Pediatrics, 20(1), 1-9.
  • Immunization coverage. World Health Organization. Retrieved from https://www.who.int/news-room/fact-sheets/detail/immunization-coverage
  • de Oliveira, L. H., Camacho, L. A., Coutinho, E. S., Martinez-Silveira, M. S., Carvalho, A. F., Ruiz-Matus, C., … & Andrus, J. K. (2015). Impact and effectiveness of Haemophilus influenzae type b conjugate vaccination in children and adults. Revista Panamericana de Salud Pública, 37(3), 147-154.
  • Zanetti, A. R., Van Damme, P., Shouval, D., Van Herck, K., Van Der Meeren, O., Esteban, R., … & Hezode, C. (2008). The global impact of vaccination against hepatitis B: A historical overview. Vaccine, 26(49), 6266-6273.

Environmental health and disease prevention

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Written By THT Editorial Team

Sanjogta Thapa Magar

Reviewed by Sanjogta Thapa Magar, Food Microbiologist

Environmental health refers to the study of how environmental factors can impact human health. These environmental factors can include air and water pollution, exposure to toxins, and even climate change. Environmental health is a crucial aspect of disease prevention and management, as it can help us identify and reduce risks that may be contributing to the development of diseases.

Air pollution is a significant environmental health concern. It is linked to various respiratory and cardiovascular conditions, including asthma, chronic obstructive pulmonary disease (COPD), and heart disease. In addition to outdoor air pollution, indoor air pollution can also be a concern, especially in homes with poor ventilation or where harmful chemicals are present.

Water safety is another crucial aspect of environmental health. Contaminated water can lead to the spread of infectious diseases, including cholera, typhoid, and hepatitis A. Proper sanitation and access to clean drinking water are essential for preventing these diseases.

In recent years, the impact of climate change on human health has become increasingly clear. Rising temperatures, extreme weather events, and changing disease patterns are all linked to climate change. Climate change can also contribute to the spread of diseases carried by insects, such as mosquitoes, ticks, and fleas.

To prevent and manage diseases related to environmental factors, it is essential to address the root causes of these issues. This can include reducing emissions that contribute to air pollution, improving water treatment and sanitation infrastructure, and taking steps to mitigate the effects of climate change.

Nepal faces various environmental health challenges that can lead to an increased risk of disease. For example, air pollution is a major concern in Nepal, particularly in cities such as Kathmandu. According to a study published in the International Journal of Environmental Research and Public Health 2, air pollution levels in Kathmandu exceed the World Health Organization’s recommended limits, with particulate matter being a major pollutant. This can lead to respiratory problems and other health issues.

Additionally, water safety is another concern in Nepal. According to a study published in the Journal of Water and Health 1, water quality in Nepal can be compromised due to factors such as poor sanitation and inadequate water treatment facilities. This can lead to the spread of waterborne illnesses such as cholera and diarrhea.

Finally, noise pollution is also a concern in Nepal, particularly in urban areas. According to a study published in the Journal of Environmental and Public Health 3, exposure to high levels of noise pollution can lead to various health issues, including cardiovascular disease and mental health problems.

Overall, addressing environmental health challenges such as air pollution, water safety, and noise pollution is crucial for disease prevention and management in Nepal. This requires a combination of individual actions, such as reducing car use and properly disposing of waste, as well as larger-scale efforts, such as improving infrastructure and implementing effective policies.

REFERENCES

Strategies for reducing the risk of infectious diseases

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Written By THT Editorial Team

Sanjogta Thapa Magar

Reviewed by Sanjogta Thapa Magar, Food Microbiologist

Infectious diseases are caused by pathogenic microorganisms such as bacteria, viruses, fungi, and parasites, and can spread from one person to another through different modes of transmission. Some infectious diseases can be prevented by taking certain precautions. Here are some strategies that can help reduce the risk of infectious diseases:

1. Handwashing: Regular and proper handwashing is one of the most effective ways to prevent the spread of infectious diseases. Hands should be washed thoroughly with soap and water for at least 20 seconds, especially after using the toilet, before eating, and after being in public places.

2. Safe food handling: Foodborne illnesses can be caused by eating contaminated food. Therefore, it is important to handle and cook food safely to prevent the spread of infectious diseases. This includes washing hands before handling food, cooking food thoroughly, storing food properly, and avoiding cross-contamination between raw and cooked foods.

3. Vaccination: Vaccines can help prevent many infectious diseases. Immunization programs have helped reduce the incidence of diseases such as measles, mumps, rubella, polio, and hepatitis B.

4. Safe sex: Sexually transmitted infections (STIs) can be prevented by practicing safe sex, which includes using condoms, getting tested for STIs, and limiting the number of sexual partners.

5. Covering the mouth and nose: When coughing or sneezing, it is important to cover the mouth and nose with a tissue or the inside of the elbow to prevent the spread of respiratory infections.

6. Avoiding close contact: Some infectious diseases can be spread through close contact with infected people. Therefore, it is important to avoid close contact with people who are sick and to stay home when feeling ill to avoid spreading the disease to others.

7. By following these strategies, individuals can reduce their risk of contracting and spreading infectious diseases.

Food allergies and intolerances: Causes, symptoms, and management

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Written By THT Editorial Team

Sanjogta Thapa Magar

Reviewed by Sanjogta Thapa Magar, Food Microbiologist

Food allergies and intolerances are becoming increasingly common, affecting millions of people worldwide. While they may seem similar, there are important differences between the two conditions. A food allergy is a reaction by the immune system to a specific food, while a food intolerance is a reaction to a food that does not involve the immune system. Both conditions can cause uncomfortable symptoms and can be difficult to manage. In this article, we will explore the causes, symptoms, and management of food allergies and intolerances.

Causes of Food Allergies and Intolerances

Food allergies occur when the immune system overreacts to a specific protein in food, treating it as a harmful invader. This triggers an immune response, which can cause a range of symptoms, from mild to severe. The exact cause of food allergies is not fully understood, but it is believed to be a combination of genetic and environmental factors.

Common food allergens include milk, eggs, peanuts, tree nuts, fish, shellfish, soy, and wheat. These foods are responsible for the majority of food allergies. It is important to note that even small amounts of these foods can trigger an allergic reaction in some people.

Food intolerances, on the other hand, are caused by a digestive system that is unable to properly digest certain foods. This can be due to a lack of a specific enzyme or sensitivity to a food additive. Unlike food allergies, food intolerances do not involve the immune system and are not life-threatening. However, they can still cause uncomfortable symptoms, such as bloating, gas, and diarrhea.

Symptoms of Food Allergies and Intolerances

The symptoms of food allergies and intolerances can vary widely depending on the individual and the severity of the reaction. In some cases, symptoms may appear within minutes of eating the offending food, while in others, they may take several hours or even days to appear.

Symptoms of food allergies can include:

Hives or rash

Itching or swelling of the lips, tongue, or throat

Shortness of breath or wheezing

Abdominal pain or cramping

Nausea or vomiting

Diarrhea

Anaphylaxis, a severe and potentially life-threatening reaction that can cause difficulty breathing, loss of consciousness, and a drop in blood pressure.

Symptoms of food intolerances can include:

Bloating

Gas

Abdominal pain or cramping

Diarrhea or constipation

Nausea

Management of Food Allergies and Intolerances

The management of food allergies and intolerances involves avoiding the offending food or ingredient. For people with food allergies, this means avoiding the allergen completely, which can be challenging as many foods contain hidden allergens. It is important to read food labels carefully and to ask questions when eating out.

In addition to avoiding the allergen, people with food allergies may carry an epinephrine auto-injector, which can be used in case of a severe allergic reaction. It is also important for family members and caregivers to know how to use the auto-injector in case of an emergency.

For people with food intolerances, avoiding the offending food can be a bit more complex. In some cases, it may be necessary to eliminate the food completely from the diet, while in others, it may be possible to consume small amounts without triggering symptoms. It is important to work with a healthcare provider or registered dietitian to develop a plan for managing food intolerances.

There are also several strategies that can help reduce the risk of allergic reactions. These include:

Reading food labels carefully and avoiding foods that contain the allergen

Informing family members, friends, and caregivers about the allergy

Carrying an epinephrine auto injector at all times, and knowing how to use it

Avoiding cross-contamination by thoroughly cleaning surfaces and utensils that have come into contact with allergenic foods Asking questions about ingredients and preparation methods when eating out Being prepared for emergencies by carrying a medical alert bracelet or necklace that identifies the allergy Taking steps to manage stress, as stress can exacerbate symptoms in some people with food allergies and intolerances

In addition to these strategies, there are also several treatment options available for people with food allergies. One of the most promising treatments is oral immunotherapy (OIT), which involves gradually introducing small amounts of the allergen under medical supervision. This can help desensitize the immune system and reduce the severity of allergic reactions over time. OIT is currently available for peanut, egg, and milk allergies, and is being studied for other food allergens as well.

Another promising treatment for food allergies is the use of biologic drugs, which target specific parts of the immune system involved in allergic reactions. For example, omalizumab is a drug that can reduce the severity of allergic reactions in people with asthma and certain food allergies. Dupilumab is another biologic drug that has shown promise for the treatment of peanut allergies.

There are also several complementary and alternative therapies that may be helpful for managing food allergies and intolerances, although more research is needed to determine their effectiveness. These include:

Probiotics, which may help regulate the immune system and reduce inflammation Omega-3 fatty acids, which have anti-inflammatory properties and may help reduce the risk of allergies Acupuncture, which may help reduce symptoms of food intolerances Herbal supplements, such as butterbur and stinging nettle, which may have anti-inflammatory properties

While these therapies may be helpful for some people, it is important to discuss them with a healthcare provider before trying them, as they can have side effects and may interact with other medications.

Conclusion

Food allergies and intolerances are common conditions that can cause a range of uncomfortable symptoms, from mild to severe. While they may seem similar, there are important differences between the two conditions. Food allergies involve the immune system and can be life-threatening, while food intolerances do not involve the immune system and are not life-threatening. The management of food allergies and intolerances involves avoiding the offending food or ingredient, and in some cases, may involve oral immunotherapy or biologic drugs. It is important to work with a healthcare provider or registered dietitian to develop a plan for managing food allergies and intolerances, and to be prepared for emergencies by carrying an epinephrine auto-injector and medical alert jewelry. With proper management, most people with food allergies and intolerances can lead healthy, happy lives.

REFERENCES

The effects of intermittent fasting on weight loss and body composition

Intermittent fasting has become a popular dietary approach for weight loss and body composition improvement. This method involves alternating periods of calorie restriction with periods of normal eating. In this article, we will explore the effects of intermittent fasting on weight loss and body composition and discuss recent research findings on this topic.

Weight Loss

Intermittent fasting has been shown to promote weight loss by reducing calorie intake and increasing fat burning. A systematic review and meta-analysis of randomized controlled trials found that intermittent fasting resulted in significant weight loss compared to continuous calorie restriction diets (1). Another study reported that participants who followed an intermittent fasting diet lost more weight and fat mass than those who followed a continuous calorie restriction diet (2).

Body Composition

Intermittent fasting has also been found to have positive effects on body composition by reducing body fat while preserving lean muscle mass. A study in overweight and obese adults found that intermittent fasting resulted in a significant reduction in body fat and an increase in lean muscle mass compared to a continuous calorie restriction diet (3). Another study reported that intermittent fasting improved body composition by reducing body fat and increasing muscle mass in resistance-trained men (4).

Other Health Benefits

In addition to weight loss and body composition improvements, intermittent fasting has been associated with other health benefits, including improved blood sugar control, reduced inflammation, and improved cardiovascular health (5). However, more research is needed to confirm these findings and determine the optimal timing and duration of intermittent fasting for these health benefits.

Popular Intermittent Fasting Methods

There are several popular intermittent fasting methods, including the 16/8 method, the 5:2 method, and alternate day fasting. The 16/8 method involves restricting calorie intake to an 8-hour window each day, while allowing normal eating during the remaining 16 hours. The 5:2 method involves consuming normal calories for five days a week and restricting calorie intake to 500-600 calories on two non-consecutive days. Alternate day fasting involves alternating days of unrestricted eating with days of complete or partial calorie restriction.

Drawbacks

Intermittent fasting may not be suitable for everyone, and some people may experience negative effects such as hunger, fatigue, and irritability. Additionally, people with certain medical conditions, such as diabetes, may need to be cautious when practicing intermittent fasting (6). It is important to consult a healthcare provider before starting any new diet or lifestyle changes.

Conclusion

Intermittent fasting has been shown to be an effective approach for weight loss and body composition improvements. The 16/8 method, 5:2 method, and alternate day fasting are popular approaches to intermittent fasting. However, it is important to consider individual needs and consult with a healthcare provider before starting any new dietary approach.

REFERENCES

  • Ganesan K, Habboush Y, Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. Cureus. 2018;10(7):e2947.
  • Moro T, Tinsley G, Bianco A, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med. 2016;14(1):290.
  • Tinsley GM, Forsse JS, Butler NK, et al. Time-restricted feeding in young men performing resistance training: A randomized controlled trial. Eur J Sport Sci. 2017;17(2):200-207.
  • Varady KA, Bhutani S, Klempel MC, et al. Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial. Nutr J. 2013;12:146.

Vaccinations

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Written By THT Editorial Team

Reviewed by Dr. Ram Prasad Neupane , DM MDGP,  Professor at Tribhuvan University, Maharajgunj Medical Campus

Vaccination are critical tools for preventing and managing various diseases. Vaccines work by introducing a weakened or inactive form of a virus or bacteria into the body, which triggers an immune response. This immune response allows the body to recognize and fight the virus or bacteria in the future, which can prevent illness or reduce its severity.

In Nepal, vaccination efforts have been crucial in preventing the spread of communicable diseases. The government of Nepal, along with various international organizations, has implemented several vaccination programs to protect the population from diseases such as measles, rubella, polio, and hepatitis B. These programs have been particularly successful in reducing the incidence of communicable diseases among children.

For example, the measles vaccine has been a significant contributor to the reduction in measles cases in Nepal. In 2018, Nepal launched a nationwide measles-rubella vaccination campaign, aiming to reach over 12 million children aged 9 months to 15 years. The campaign targeted hard-to-reach areas and populations with low coverage, resulting in a significant increase in measles vaccination coverage. As a result of these efforts, the number of measles cases in Nepal decreased from over 2,400 in 2016 to just 118 in 2019.

In addition to preventing the spread of diseases, vaccination also play a crucial role in managing chronic illnesses. For example, individuals with chronic illnesses such as diabetes, heart disease, and asthma are at increased risk of developing complications from infectious diseases. By getting vaccinated, individuals with chronic illnesses can reduce their risk of developing serious complications or hospitalization from vaccine-preventable diseases.

Overall, vaccination are critical components of disease prevention and management efforts. These programs not only protect individuals from infectious diseases but also contribute to the overall health of the population. It is important to continue to prioritize and invest in vaccination and immunization programs to ensure that everyone has access to these lifesaving interventions.
Here is a list of vaccines that are typically given to a child since birth:

1. Hepatitis B: Given within the first 12 hours of birth

2. DTaP (diphtheria, tetanus, and pertussis): Given at 2, 4, and 6 months of age
3. Hib (haemophilus influenzae type b): Given at 2, 4, and 6 months of age
4. IPV (polio): Given at 2, 4, and 6 months of age
5. PCV13 (pneumococcal conjugate vaccine): Given at 2, 4, and 6 months of age
6. Rotavirus: Given at 2 and 4 months of age
7. Hepatitis A: Given at 12 months of age
8. MMR (measles, mumps, and rubella): Given at 12 months of age
9. Varicella (chickenpox): Given at 12 months of age
10. DTaP booster: Given at 15-18 months of age
11. Hib booster: Given at 12-15 months of age
12. IPV booster: Given at 4-6 years of age
13. MMRV (measles, mumps, rubella, and varicella): Given at 4-6 years of age
14. DTaP booster: Given at 11-12 years of age

HPV (human papillomavirus): Given at 11-12 years of age (can be given as early as 9 years old)
Here are some other commonly used vaccines for adults and children:
1. HPV vaccine: protects against the human papillomavirus, which can cause several types of cancer.
2. Meningococcal vaccine: protects against meningococcal disease, a serious bacterial infection that can cause meningitis and blood infections.
3. Pneumococcal vaccine: protects against pneumococcal disease, which can cause pneumonia, meningitis, and blood infections.
4. Hepatitis A vaccine: protects against hepatitis A, a viral infection that can cause liver inflammation.
5. Hepatitis B vaccine: protects against hepatitis B, a viral infection that can cause liver inflammation and potentially lead to long-term liver problems.
6. Varicella (chickenpox) vaccine: protects against chickenpox, a highly contagious viral infection that causes a blister-like rash, itching, and fever.
7. Rotavirus vaccine: protects against rotavirus, a common cause of severe diarrhea and dehydration in infants and young children.

Vaccine myths:
There are many myths and misconceptions about vaccines that can cause confusion and lead to vaccine hesitancy. Some common vaccine myths include:

Vaccines cause autism: This myth has been thoroughly debunked by multiple studies, yet it still persists in some communities.
Vaccines are not necessary because the diseases they prevent are rare: While it is true that some vaccine-preventable diseases are now less common in certain parts of the world, this is largely due to the widespread use of vaccines. If vaccination rates were to drop, these diseases could quickly make a comeback.
Vaccines can cause serious side effects: While all vaccines can cause some side effects, serious reactions are extremely rare. The benefits of vaccination far outweigh the risks.
Natural immunity is better than vaccine-induced immunity: While natural immunity can be effective, it comes at a cost. Many vaccine-preventable diseases can cause serious complications, including death. Vaccines provide a safe and effective way to build immunity without the risk of serious illness or death.
Vaccines contain harmful ingredients: Some people are concerned about the ingredients in vaccines, such as thimerosal (a preservative) or aluminum. However, these ingredients are used in such small amounts that they are not harmful.

Supporting loved ones with mental health challenges

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Written By THT Editorial Team

Dr. Kamal Gautam

Reviewed by Dr. Kamal Gautam, MBBS(KU), MD Psych (IOM), Currently working at Transcultural Psychological Organization Nepal (TPO Nepal)

Supporting loved ones with mental health challenges is an important aspect of mental health and well-being. Recent research has shown that social support can have a significant impact on the mental health of individuals with mental illnesses. A study published in the Journal of Consulting and Clinical Psychology found that providing social support to individuals with mental illnesses can lead to a reduction in symptoms and an overall improvement in their quality of life (Suetani et al., 2021).

Some ways to support loved ones with mental health challenges include:

A. Educate yourself about their condition: Learning about the symptoms and treatment options for your loved one’s mental illness can help you understand their experience and provide more effective support.

B. Be a good listener: Sometimes all your loved one may need is someone to listen to them without judgment or criticism. Try to offer an open ear and show empathy.

C. Encourage treatment: Encouraging your loved one to seek professional treatment can be a difficult conversation, but it is important to express your concern for their well-being and offer support in finding appropriate resources.

D. Offer practical help: Tasks that may seem simple, such as preparing meals or running errands, can be challenging for individuals with mental health issues. Offering practical assistance can be a great way to show support.

E. Avoid stigma and judgment: Mental health stigma and judgment can prevent individuals from seeking treatment and support. Be mindful of your language and avoid using derogatory terms or perpetuating negative stereotypes.

Supporting loved ones with mental health challenges can be a challenging and emotional journey. It is important to remember that you do not have to go through it alone. Seeking out support from a mental health professional, support group, or trusted friend or family member can also be helpful.

REFERENCES

  • Suetani, S., Kisely, S., & Siskind, D. J. (2021). The effectiveness of social support interventions for people with severe mental illness: A systematic review and meta-analysis of randomised controlled trials. Journal of Consulting and Clinical Psychology, 89(4), 303-317. doi: 10.1037/ccp0000651