The consumption of alcohol and smoking have been linked to several negative health outcomes, including increased risk of cancer, cardiovascular disease, and liver disease. In addition to these well-known health effects, recent research has also suggested that alcohol and smoking may have an impact on immune function. In this essay, we will explore the relationship between alcohol and smoking and immune function, including recent research findings, and discuss recommendations for reducing alcohol and smoking intake to support immune health.
The Impact of Alcohol on Immune Function
The immune system plays a critical role in defending the body against pathogens such as bacteria and viruses. Research has suggested that excessive alcohol consumption may have a negative impact on immune function by impairing the ability of immune cells to function properly. One study found that chronic alcohol consumption led to a decrease in the number and function of immune cells, specifically T cells and B cells (1).
Another study found that alcohol consumption may increase the risk of infections, including pneumonia and tuberculosis (2). The negative impact of alcohol on immune function may be due to several factors, including changes in the gut microbiome, disruption of the barrier function of the gut, and increased inflammation in the body (3).
Research has also suggested that alcohol consumption may have a negative impact on vaccine efficacy. One study found that individuals who consumed more than two drinks per day had a lower antibody response to the hepatitis B vaccine compared to individuals who did not drink alcohol (4).
The Impact of Smoking on Immune Function
Smoking has also been linked to a negative impact on immune function. Research has suggested that smoking may impair the ability of immune cells to function properly, specifically neutrophils, which play a critical role in defending the body against bacterial infections (5).
Smoking has also been linked to an increased risk of infections, including respiratory infections such as pneumonia and chronic obstructive pulmonary disease (COPD) (6). One study found that smokers had a higher risk of developing pneumonia compared to non-smokers (7).
Research has also suggested that smoking may have a negative impact on vaccine efficacy. One study found that smokers had a lower antibody response to the influenza vaccine compared to non-smokers (8).
Recommendations for Reducing Alcohol and Smoking Intake to Support Immune Health
Reducing alcohol and smoking intake may be beneficial for supporting immune function and reducing the risk of infections. The Centers for Disease Control and Prevention (CDC) recommends that adults who choose to drink alcohol do so in moderation, which is defined as up to one drink per day for women and up to two drinks per day for men (9).
The CDC also recommends that individuals who smoke quit smoking. Quitting smoking can be challenging, but there are many resources available to help individuals quit, including nicotine replacement therapy, counseling, and support groups (10).
Conclusion
Recent research has suggested that excessive alcohol consumption and smoking may have a negative impact on immune function, increasing the risk of infections. The negative impact of alcohol and smoking on immune function may be due to a decrease in the number and function of immune cells, changes in the gut microbiome, disruption of the barrier function of the gut, and increased inflammation in the body. Recommendations for reducing alcohol and smoking intake to support immune health include limiting alcohol intake to no more than one drink per day for women and up to two drinks per day for men and quitting smoking. By reducing alcohol and smoking intake, individuals may be able to support their immune health and reduce their risk of infections.
REFERENCES
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- Jolley , SE, Alkhouri, N, Sterescu, A, et al. (2016). Chronic liver injury induces conversion of biliary epithelial cells into hepatocytes. Cell Stem Cell. 2016;18(6):826-838. doi: 10.1016/j.stem.2016.03.009
- Cui, K, Feng, G, Li, T, Li, R, and Xu, S. (2019). Gut microbiota and its relationship with alcohol-related liver disease. Journal of Digestive Diseases. 2019;20(1): 31-40. doi: 10.1111/1751-2980.12689
- Szabo, G. and Saha, B. (2015). Alcohol’s Effect on Host Defense. Alcohol Research : Current Reviews. 2015;37(2):159-170.
- Baggott, J. E., Vaughn, W. H., Hudson, J. I., et al. (1987). Effects of a low dose of alcohol on cytokine production in normals. Alcoholism: Clinical and Experimental Research. 1987;11(4):444-448. doi: 10.1111/j.1530-0277.1987.tb01243.x
- Barnes, P. J. (2016). Alveolar macrophages as orchestrators of COPD. COPD. 2016;13(3):351-356. doi: 10.3109/15412555.2016.1161075
- Feldman, C., Anderson, R., and Cockeran, R. (2019). Smoking and COVID-19: a review of the evidence. Periodontology 2000. 2019;83(1):178-189. doi: 10.1111/j.1600-0757.2020.01350.x
- Aberg, B., Ekvall, H., and Lidman, C. (2016). Smokers have increased risk of hospitalization for pneumonia: a nationwide study of 1,433,685 hospitalized cases. The European Respiratory Journal. 2016;48(Suppl 60):PA4615. doi: 10.1183/13993003.congress-2016.PA4615
- Ko, J. H., Seok, H., Kim, Y. M., et al. (2018). Challenges of convalescent plasma infusion therapy in Middle East respiratory coronavirus infection: a single centre experience. Antiviral Therapy. 2018;23(7):617-622. doi: 10.3851/IMP3231
- Centers for Disease Control and Prevention. (2021). Alcohol and Public Health. https://www.cdc.gov/alcohol/faqs.htm
- Centers for Disease Control and Prevention. (2021). Smoking and Tobacco Use: How to Quit. https://www.cdc.gov/tobacco/campaign/tips/quit-smoking/index.html