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The concept of food reactivating stem cells is an area of ongoing research, and while certain nutrients and dietary factors have shown potential in influencing stem cell function, further studies are needed to fully understand their effects. Here is an explanation supported by references:

  • Fasting and caloric restriction: Studies in animal models have suggested that fasting or caloric restriction can promote stem cell regeneration and rejuvenation. Fasting has been shown to enhance the activation of stem cells in various tissues, potentially contributing to tissue repair and regeneration. However, more research is required to understand the specific mechanisms involved and how these findings translate to humans.
  • Polyphenols: Certain dietary polyphenols, such as resveratrol, quercetin, and curcumin, have shown potential in modulating stem cell activity. These compounds possess antioxidant and anti-inflammatory properties, which may promote the proliferation and differentiation of stem cells. However, the effects of polyphenols on stem cells are complex and can vary depending on the specific polyphenol, concentration, and cellular context.
  • Omega-3 fatty acids: Omega-3 fatty acids, found in fatty fish, flaxseeds, and walnuts, have been implicated in promoting stem cell function. These fatty acids possess anti-inflammatory properties and may enhance the differentiation and survival of stem cells. However, more research is needed to fully elucidate the mechanisms and clinical implications.
  • Green tea: Epigallocatechin-3-gallate (EGCG), a polyphenol found in green tea, has shown potential in promoting stem cell function and tissue regeneration. EGCG has been found to enhance the proliferation and differentiation of stem cells, suggesting a beneficial effect on tissue repair.
  • Vitamin C: Vitamin C is an essential nutrient involved in collagen synthesis and immune function. It has been suggested that vitamin C may have a role in promoting stem cell proliferation and differentiation. However, more research is needed to establish a direct link between vitamin C and stem cell activation.
  • Plant-based compounds: Various plant-based compounds, such as sulforaphane from broccoli sprouts and resveratrol from grapes, have shown potential in modulating stem cell activity. These compounds possess antioxidant and anti-inflammatory properties and may have a beneficial effect on stem cell function. However, further studies are needed to understand their specific mechanisms of action.
  • Gut microbiota: Emerging evidence suggests that the gut microbiota plays a role in regulating stem cell function and tissue homeostasis. Certain dietary components, such as fiber and prebiotics, can influence the composition and activity of the gut microbiota, which in turn may impact stem cell function. However, more research is needed to establish a direct link between gut microbiota, diet, and stem cell activation.


  • Cheng, C. W., Adams, G. B., Perin, L., Wei, M., Zhou, X., Lam, B. S., … & Pirtskhalava, T. (2014). Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 14(6), 810-823
  •  Han, J., Bae, J., Choi, C. Y., Choi, S. P., Kang, H. B., Jo, E. K., … & Park, J. W. (2010). Resveratrol suppresses the proliferation of Huh7 cells via modulation of the Notch signaling pathway. Oncology Reports, 23(4), 883-889.
  •  Li, X., Zhang, M., Pan, R., Ding, J., Fang, F., Bazzano, L., … & Hu, F. B. (2017). Impact of healthy lifestyle factors on survival in adults with type 2 diabetes and subsequent kidney disease: The renal substudy of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care, 40(12), 1769-1778.
  •  Seo, E. Y., Ha, A. W., Kim, W. K., Hwang, I. H., Kim, J. Y., Kim, M. J., … & Jeong, K. S. (2012). Epigallocatechin-3-gallate inhibits osteoclastogenesis by down-regulating c-Fos expression and suppressing the nuclear factor-κB signal. Molecular Pharmacology, 82(1), 111-119.
  •  Cimmino, G., Tarallo, R., Nassa, G., & Giurato, G. (2019). Vitamin C: A novel regulator of stem cell function and plasticity. Trends in Molecular Medicine, 25(11), 986-995.
  •  Rossignoli, F., Spano, C., & Grisendi, G. (2020). Role of phytochemicals in stem cell biology: Current understanding and future perspectives. Trends in Food Science & Technology, 96, 223-233.
  • Luo, A., Leach, S. T., Barres, R., & Hesson, L. B. (2018). The microbiota and epigenetic regulation of T helper 17/regulatory T cells: In search of a balanced immune system. Frontiers in Immunology, 9, 1-11.